Background of MSCsMSC are multi-potent cells that have displayed the following abilities:
- Able to divide to form bone, cartilage, muscle, fat and other tissues such as neural tissue, pancreatic tissue under induction;
- Home to site of injury and assist in repair;
- Enhance anti-inflammatory and immunosuppression.
More than 300 clinical trials are ongoing worldwide to uncover the medical potential of MSCs. Thus far, encouraging results have been published. MSCs have also been used in combination with HSCs as a dual therapy to promote faster engraftment of HSCs and to reduce immune system complications.
MSC Clinical Trials – Global Institutions
|Diseases||Names of Universities or Research Institutions|
|Stroke||University Hospital, Grenoble, France|
|Spinal Cord Injury||
|Amyotrophic Lateral Sclerosis||Hadassah Medical Organization, Israel|
|Parkinson‘s Disease||Jaslok Hospital and Research Centre, India|
|Multiple System Atrophy||Yonsei University, South Korea|
|Liver Disease||Cytori Therapeutics, United States|
|Diabetic Foot Ulcer||
MSC Application ReportsMSC and Skeletal Repair
- Treatment for knee cartilage damage was conducted by NUH Orthopaedic Surgery of Singapore, Dr Kevin Lee;
- Since 2006, 35 patients with worn knee cartilage underwent injection of autologous ex-vivo expanded MSCs from bone marrow;
- Patients were reported to have improvements in quality of life such as regaining ability to climb stairs and reduction of pain.
Co-Transplantation of MSCs and HSCs
- In 2002, Sydney Scott was diagnosed with Acute Myeloid Leukaemia at 13 weeks;
- Baby Sydney was treated with chemotherapy followed by cord blood and MSC co-transplantation – world’s first;
- MSC thought to have enabled blood stem cell engraftment;
- Baby Sydney was relapse free and medication free at the time of report.
MSCs in Heart Attack
- 69 heart attack patients were treated;
- Following angioplasty, doctor directly injected patients’ damaged heart site with MSC harvested from patients’ own bone marrow;
- Results showed significant improvements in patients’ left ventricular function.