Potential Applications of MSC and EpSC Stem Cells

Cordlife's Exclusive: Epithelial stem cells (EpSCs)

Disorders investigated in MSC Clinical Trials Disorders investigated in EpSC Clinical Trials
  • Tissue repair
    • Stroke
    • Heart failure
    • Alzheimer’s disease
    • Parkinson’s disease
    • Spinal cord injury 
    • Orthopaedic indications (bone, cartilage, tendon repair)
    • Liver failure
  • Immune modulation or reconstitution
    • HIV
    • Type 1 diabetes
    • Graft versus host disease (GvHD)
  • HSCs engraftment support
    • Shorten time of engraftment
      Reduce immune system complications
  • Soft tissue repair
    • Skin wounds
    • Ocular surface disorders
    • Persistent epithelial defect
    • Replacement of insulin-producing cells for diabetic patients
    • Haemophilia

Today, more than 300 clinical trials1 are ongoing worldwide to uncover the potential of MSCs. Thus far, encouraging results have been published; stem cell treatments have been proven safe and capable of repairing damage caused by stroke and heart disease. MSCs have also been used in combination with HSCs as a dual therapy to promote faster engraftment of HSCs and to reduce immune system complications2.

EpSC Clinical Trials – Global Institutions

Diseases Names of Universities or Research Institutions
Skin Wound Singapore General Hospital Burn Centre
Ocular surface disorders
  • Singapore Eye Research Institute
  • Kyoto Prefectural University of Medicine, Japan
Persistent epithelial defect National Eye Institute, Hanoi, Vietnam



MSC Clinical Trials – Global Institutions

Diseases Names of Universities or Research Institutions
Stroke University Hospital, Grenoble, France
Spinal Cord Injury
  • Chinese University of Hong Kong
  • Cairo University, Egypt
Multiple Sclerosis
  • Spain-Carlos Health Institute
  • University of Cambridge, United Kingdom
  • Cleveland Clinic, United States
Amyotrophic Lateral Sclerosis Hadassah Medical Organization, Israel
Parkinson‘s Disease Jaslok Hospital and Research Centre, India
Multiple System Atrophy Yonsei University, South Korea
Liver Disease Cytori Therapeutics, United States
Diabetic Foot Ulcer
  • Third Military Medical University, China
  • Washington DC Veterans Medical Centre, United States
  • Ruhr-University Bochum, Germany
Diabetes
  • Fuzhou General Hospital, China
  • Uppsala University, Sweden

 

Worldwide researches on diseases treated with MSCs by various universities or institutions:
Diseases Name of universities or research Institions
Stroke University Hospital, Grenobe, France
Spinal Cord Injury
  • Cairo University, Egypt
  • Chinese University of Hong Kong
Multiple Sclerosis
  • Spain-Carlos Health Institute
  • University of Cambridge, U.K.
  • Cleveland Clinic, U.S.
Amylotrophic Lateral Sclerosis Hadassah Medical Organization, Israel
Parkinson's Disease Jaslok Hospital and Research Centre, India
Multiple System Atrophy Yonsei University, South Korea
Liver Disease Cytori Therapeutics, U.S.
Diabetic Foot Ulcer
  • Third Military Medical University, China
  • Washington DC Veterans Medical Centre, U.S.
  • Ruhr-University Bochum, Germany
Diabetes
  • FUzhou General Hospital, China
  • Uppsala University, Sweden
QR 8.1-7-3-a DCR 800

 

 

Sources:

  1. ClinicalTrials.gov. Accessed in October 2013.
  2. Battiwalla M, Hematti P. 2010. Cytotherapy. 1 January 2010.