{"id":941,"date":"2017-07-07T18:00:51","date_gmt":"2017-07-07T12:30:51","guid":{"rendered":"https:\/\/www.cordlifeindia.com\/blog\/?p=941"},"modified":"2025-02-12T11:56:56","modified_gmt":"2025-02-12T06:26:56","slug":"huntingtons-disease","status":"publish","type":"post","link":"https:\/\/www.cordlifeindia.com\/blog\/huntingtons-disease\/","title":{"rendered":"Cellular Traffic Jam Is The Culprit Behind Huntington\u2019s Disease"},"content":{"rendered":"<style>html { scroll-behavior: smooth; scroll-padding-top: 5em; .table_of_contents {margin: 25px 0; padding: 10px; background: #F2F5F7;} .table_of_contents a { text-decoration: none; }}<\/style><div class='table_of_contents'><h3>Table of Contents<\/h3><ul><\/ul><\/div><p><u><\/u>Researchers were wondering from ages as to what could be the actual cause of Huntington\u2019s disease which causes involuntary jerky body movements disabling the victim to exhibit physical and mental coordination. The awkward bodily momentum gradually worsens after the initial unsteady gait putting the victim in jeopardy. Parental inheritance being the focal reason, this disease is hard to prevent and has been affecting millions of people globally without a documented cure. However, the available treatments reduce the severity of the symptoms and aid the victim in lessening the care giving requirements.<\/p>\n<p>To enhance the quality of life of the global populace affected with Huntington\u2019s disease, researchers are looking forward to get core advancement in finding an explicit medical solution. However, the extensive research to find the root cause of Huntington\u2019s disease has enabled the researchers to get a key which can be a potential advancement in finding a generic solution to lessen the severity of the ailment. It is established that a mutant of the Huntington (mHTT) protein is the fundamental cause of the disease though the researchers are still unclear as to how it disturbs the brain cells\u2019 function. As per the established findings of late, mHTT vitiates the cellular transport process adding to the neurotoxicity eventually resulting in loss of neurons.<\/p>\n<p>Caused by an extended CAG repeat in the <em>Huntington<\/em> <em>(HTT)<\/em> gene, this neurodegenerative disease with mHTT plays pivotal role in disrupting the transport system of a cell which normally requires mobilizing multiple elements from its nucleus to the other parts and vice-versa. It has been pragmatically realized that mHTT creates aggregates in the central operations area that is in the nucleus preventing it from passing through the nuclear pores. \u00a0This pile up in the mHTT following the stagnation in the nuclear passages kills the brain cells by shutting them down.<\/p>\n<p>The new fact discovered can drive the researchers to find out new ways to fix the cellular traffic jams there by aiding the process of finding new treatment methodologies for the Huntington\u2019s disease. Although it is a fact that this step towards an advanced research in finding the cause for the disease is in the initial stage, the researchers are excited with their discovery as these findings are the stepping stones in conquering the Huntington\u2019s disease along with encouraging the search for new therapeutic modules.<\/p>\n<p>Biotech companies and pharmacy companies are looking forward to dwell on this very concept to capitalize it and bring into existence various therapies for biological processes. Hope they get abundant clues to prove the fact that<strong> early birds get quick worms <\/strong>in the course of their research. Ultimately, it is the millions of people who are affected with the Huntington\u2019s disease who get the best of the research.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Table of ContentsResearchers were wondering from ages as to what could be the actual cause of Huntington\u2019s disease which causes involuntary jerky body movements disabling the victim to exhibit physical and mental coordination. The awkward bodily momentum gradually worsens after the initial unsteady gait putting the victim in jeopardy. Parental inheritance being the focal reason, [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":942,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[231,265,276,157,468,158,244,316],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Cellular Traffic Jam Is The Culprit Behind Huntington\u2019s Disease<\/title>\n<meta name=\"description\" content=\"Huntington (mHTT) protein is the fundamental cause of the disease though the researchers are still unclear. 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