According to Medical News Today, “Strokes occur due to problems with the blood supply to the brain: either the blood supply is blocked or a blood vessel within the brain ruptures, causing brain tissue to die. A stroke is a medical emergency, and treatment must be sought as quickly as possible.”

Strokes can be of three types, namely, a) Transient ischemic attacks (TIAs); b) Ischemic strokes; and c) Hemorrhagic strokes.

Currently, the only US Food and Drug Administration (FDA) approved treatment for strokes involves the tissue plasminogen activator or tPA. Basically, these are used to dissolve the blood clots that are formed in the event of a stroke when the arteries are blocked preventing adequate flow of blood to the brain. It is essential that the tPA is provided to patients within 3 to 4 hours after the stroke happens in order for it to be effective. If a patient cannot reach the hospital in time for the tPA to be administered then more often than not it could result in lasting damage.

However, a recent article titled ‘3K3A–activated protein C stimulates post-ischemic neuronal repair by human neural stem cells in mice’ stated the possibility of the damage being cured. The article stated that a team based at the University of Southern California (USA) conducted a research using a mixture of one-two punch stem cells along with a protein that assists cells in converting into brain cells known as neurons.

Author Kevin McCormack, in his article regarding the research, stated, “First, the researchers induced a stroke in mice and then transplanted human neural stem cells alongside the damaged brain tissue. They then added a dose of the protein 3K3A-APC or a placebo. They found that mice treated with 3K3A-APC had 16 times more human stem-cell derived neurons than the mice treated with the placebo. Those neurons weren’t just sitting around doing nothing.”

In order to ensure that the improvement witnessed in the mice was solely due to the 3K3A-ACP cell that had been transplanted into them, the researchers killed the neurons that they had produced with the help of a toxin. The result was that the mice were reverted to their previous state and could not be differentiated from other untreated mice.

Other studies have also been conducted which have conclusively proved that when stroke victims were injected with stem cells gathered from borrowed bone marrows, they displayed a marked improvement from their previous state and were also able to regain some amount of bodily movements.

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To start with, let us first understand what is ‘delayed cord clamping’.

According to the International Childbirth Education Association, “Delayed cord clamping is a birth practice where the umbilical cord is not clamped or cut until after pulsations have ceased, or until after the placenta is delivered.”

Now you may ask why this procedure is necessary and how does it impact your baby. At the time of birth, your baby’s body contains two-thirds of the blood whilst the placenta contains about one-third of the blood. Studies have revealed that a delay in the clamping of the umbilical cord can provide newborns approximately 30% more of the foetal-placental blood volume. Thus, delaying the cord clamping will give your baby a healthy blood volume.

Let Us Look At Some More Benefits That Delayed Cord Clamping Can Offer:

• The extra blood that delayed cord clamping provides to your baby can prevent anemia. Since breast milk does not provide sufficient amounts of iron which is important not only for preventing anemia but also for your baby’s brain development, the blood received from delayed clamping can deliver the extra iron content needed by your baby’s body.
• Delayed cord clamping allows your baby to incorporate an increased amount of stem cells into their body as the production of stem cells is highest at the time of birth. Stem cells are a core part of the body’s anatomy. They have the potential to repair and cure any type of internal injuries or illnesses.
• Some studies have shown that the extra time taken to detach the umbilical cord can give your baby a neurodevelopmental boost in later life.
• As mentioned before, delayed cord clamping increases the baby’s blood volume which in turn promotes a healthy neonatal cardiopulmonary transition.
• In the cases of babies who are born prematurely, delayed cord clamping can allow them to have stabilized blood pressure in the days succeeding the birth.

Although delayed cord clamping has several benefits, the ideal time for cord clamping is a topic of much debate. According to the American College of Obstetricians and Gynaecologists “Several systematic reviews have suggested that clamping the umbilical cord in all births should be delayed for at least 30–60 seconds, with the infant maintained at or below the level of the placenta because of the associated neonatal benefits, including increased blood volume, reduced need for blood transfusion, decreased incidence of intracranial hemorrhage in preterm infants, and lower frequency of iron deficiency anemia in term infants. Evidence exists to support delayed umbilical cord clamping in preterm infants, when feasible. The single most important clinical benefit for preterm infants is the possibility for a nearly 50% reduction in intraventricular hemorrhage. However, currently, the evidence is insufficient to confirm or refute the potential for benefits from delayed umbilical cord clamping in term infants, especially in settings with rich resources.”

Delayed cord clamping is a common practice amongst most doctors and has no effect on the process of cord blood collection since the cord blood is collected only after the cord has completely stopped pulsating. So if you are an expecting parent and have opted for cord blood banking, you can speak to Cordlife expert today!

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Ever wondered if there is a relationship between your umbilical cord and the belly button? Of course, there is! When you have your little one inside your womb, it needs a life-support system to survive the pregnancy gestation period. This support is comprised of the placenta, the umbilical cord and the amniotic sac filled with amniotic fluid.

“The baby’s life hangs by a cord”, as said by Ian Donald, aptly tells the importance of the umbilical cord.

The umbilical cord plays the essential role of attaching your baby to the placenta and keeps feeding your baby. During delivery, the placenta is expelled from your uterus through a process known as the after-birth. The umbilical cord, once your baby is delivered is clamped and cut. The remaining section of the cord heals and later becomes the baby’s belly button.

Nevertheless, most are aware of these common facts. But there are some really fun insights that you probably never thought about:

Umbilical Cords Vary in Length

The lengths of the umbilical cords of babies are variable. However, there is no concrete evidence to ascertain why the length varies at all. Within the full gestation period of 28 weeks, the cord may reach its full length which usually is between 45-60 centimeters in length. In a small percentage of pregnancies, the cord is less than 45 centimeters in length and investigative studies have shown that placenta retention and C-section is usually higher in such instances.

Tangles, Knots, and Loops

Babies in the womb are constantly moving around. A common game that they indulge in is playing ‘loop the loop’ with the cord. If the baby is healthy and the cord remains intact, it does not really pose any risk to the baby. Approximately 35% of the babies born have the umbilical cord wrapped around their necks and 1% of them have the cord in a true knot.

It Stops Working When Needed

In the womb, the umbilical cord remains in a temperature controlled environment. Post the baby’s birth, the cord is exposed to cooler air and the ‘Wharton’s Jelly’ within it starts to harden and shrink. Natural clamping occurs that squeezes and closes the blood vessels inside the cord. Depending on the temperature outside of the mother’s body, natural clamping takes approximately between 3 and 20 minutes.

The Umbilical Cord Tissue is Full of Potential

Most of us have heard about cord blood stem cells but the new research that has everyone’s attention is on umbilical cord tissue. Many ongoing clinical trials have brought significant evidence forward that the cord blood tissue also contains stem cells that possess the potential to multiply and transform into various cell types, like cartilage, bone, fat, etc. This essentially means that the cord tissue with more stem cells can potentially be used in treating more conditions and disorders.

As Nancy Reagan rightfully said, “Now science has presented us with a hope called stem cell research, which may provide our scientists with many answers that have for so long been beyond our grasp.” 

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Expectations, anticipation and disenchanted reality of a prenatal visit. 

It was coming up to 8 weeks of pregnancy and we were both preparing for our first prenatal doctor’s appointment. I wanted to be there with my wife right from the very beginning of this journey and get to know everything first hand. I was more than happy to reshuffle my agenda for the day. Lifestyle changes had already begun; work schedules were also being tossed around.

During the past 8 weeks, my wife and I had already discussed the sort of medical guidance we wanted for us during this special journey in our lives. Someone who would be understanding and would have the patience to deal with the concerns of first-time parents like us. We asked around quite a fair bit. Whilst speaking to an old friend, he recommended a gynecologist who he’d consulted for his wife a couple of months ago. On digging a little more, I found out that the doc had a fine reputation and was very popular with young couples. I guess, we’d found the doctor we wanted!

We arrived at the birthing center well in time for the appointment. Giving our names to the Receptionist we waited for the doctor to arrive. There were so many couples and women at various stages of the pregnancy waiting along with us. I vividly remember the room. A light pink and blue combination wallpaper decorated with tons of baby photos. A standee on the side stood with a really graphical representation of all the pregnancy trimesters. My wife picked up few pamphlets and started leafing through them. This room really felt like a “happy place”. Lots of positive energy and glow filled the room.

As we waited, more and more couples arrived but there was still no sign of the doctor. I know this is India and doctors and trains rarely stick to their timetables. But I was nervous and couldn’t wait to get into that consultation room. I had tons of questions that I wanted to ask the doctor and I was eagerly waiting to hear my baby’s heartbeat for the first time. To me, that meant a great deal. It would actually seal the deal; reinforce the fact that I was going to be responsible for that little human being that I helped create.

We’d already been waiting for over an hour and I was determined to find out the reason for the delay. The clock turned another 15 minutes and I was just about gearing up to go to the Receptionist to find out what the problem was. The Receptionist came out into the Visitor’s room and announced that the doctor had an emergency normal delivery to deal with and wouldn’t be able to take the scheduled appointments for the day.

And I felt so let down. The thrill, the excitement that I was feeling throughout the day just evaporated. I know, the situation was such that I should understand. Labour pain and deliveries don’t always follow the timetable. I guess, I found some solace in the fact that I was nearly halfway there today. I’ve rescheduled and hope to go all the way into the consultation room with the doctor tomorrow. Finger’s crossed!

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“Congratulations! You’re having twins.” When Naren and Seema had been informed of this ecstatic news, they were over the moon. The couple had been trying to conceive for close to a year and finally knowing that they were about to be parents, of not just one but two babies were more than they could have asked for.

The expecting couple were very careful during the first trimester as they had been informed that chances for a miscarriage were highest during that time. They followed the doctor’s instructions to the‘t’.  After the first three months were over, they decided it was time to inform their friends and family of their good news.

At a party celebrating their news, Seema’s friend Aditi enquired of the couple regarding their plans for cord blood banking. However, neither Naren nor Seema seemed to have much information on what it was. Aditi told them that the process of storing a newborn baby’s umbilical cord blood from which stem cells can be extracted and may be used to treat a wide variety of critical diseases and disorders like leukaemia, thalassemia, etc is basically what cord blood banking was all about. Seema was intrigued with the idea; however, Naren believed “it’s just a fancy marketing ploy by healthcare companies to get money from worried expectant parents. My babies will be fine. We don’t need to store anything for them.”

Even though Naren wasn’t interested in cord blood banking, Seema started her research online. The more she read, the more she learned of the benefits that cord blood banking could provide to her children. And not just for her twins, but any other blood relatives including the children that she could have in the future.

Eventually, she decided to ask her friend as to what had convinced her to opt for cord blood banking. Aditi said, “There is a history of sickle cell anaemia in my family. There were high chances that my baby too would have it. I was worried sick thinking of what life would be like for her if that happened. My doctor then told me about stem cell therapy and how quite a few clinical trials have been conducted which revealed that stem cell therapy can be used to treat sickle cell anaemia. That’s when I decided to go for it.”

Seema realised that she too wanted to ensure the safety of her babies’ future. She had read that cerebral palsy is quite common among twins and she decided that she wanted to be prepared in case her children too were affected by this ailment. That night she sat Naren down and explained her concerns to him, finally convincing him to change his mind since their babies’ health and wellbeing were their utmost priority.

Today, Seema and Naren are proud parents of two healthy baby boys, whose cord blood had been stored with a private cord blood banking facility since their birth.

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Miracles happen. How many times have we heard this? But have you actually ever seen a miracle happen. This is the story of one man’s fight against blindness which eventually gave hope to millions of people.

It was on a family road trip to New Hampshire when the 54-year-old Doug Oliver was first made aware of how advanced his macular degeneration had become when he failed to see two pedestrians in a crosswalk and almost ran them down. The incident resulted in Doug receiving a $500 fine from a police officer who had witnessed the near accident and was also made to give up his driver’s license.

Doug had been previously diagnosed almost 20 years ago, with macular degeneration. However, back then his doctors had predicted that his vision would last until the age of 60. But following the accident, when his eyesight was reviewed, it revealed that he was almost blind. The tests showed he had 20/2000 vision in the left eye and 20/400 in the right. This new found disability severely affected his career as an IT specialist and social policy consultant. He had no choice but to depend on his monthly disability check to make ends meet.

His doctor advised Doug that the only way to find a cure for his ailment was to participate in clinical trials. After vociferously searching for such trials, Doug was finally able to reach out to a surgeon, Dr. Jeffrey Weiss who was conducting an experiment on treating macular degeneration through stem cell banking. After flying out to Florida, Doug met with the doctors who were participating in the study. They extracted a bone marrow sample from his hip bone and with the help of an FDA-approved centrifuge, isolated the stem cells which were then injected into his eyes. Within 48 hours his vision improved. The vision in the left eye was 20/40 and in the right eye was 20/30.

Following the success of the treatment, Doug said, “I could see the boats and the little wake lines that you see from 30,000 feet. I acted like a 6-year-old and loved it”.

In order to garner government funding for such procedures, Senate Health Committee Chairman Lamar Alexander invited Doug to Washington in June 2016. Doug was asked to speak to Mr. Alexander’s colleagues regarding his success story, in the hope that it would convince them to support the passing of the 21st Century Cures Act which legislates the funding of high risk, high reward clinical trials. He believes that the passing of this Act can revolutionize the healthcare industry.

So as the story goes… miracles do happen, or at least in Doug Oliver’s case, a modern ‘medical miracle’ did happen.

The post Stories of Hope: Cured Blind Man, U.S Senator Crusade on Capitol Hill for Stem Cell Innovations appeared first on Stem Cell Banking Guide and Pregnancy Tips For New Parents.

As the science of stem cells took off in the 1970s when doctors realized that the stem cells found in the blood inside an umbilical cord could offer a much more secure substitute to bone marrow transplants that may find its way in the utilization of treating conditions such as leukaemia, lymphoma, and sickle cell anemia. This is so since cord blood is power packed with multipotent, self-renewing hematopoietic stem cells (HSCs), which are the forerunners to blood cells.

The process of extracting this cord blood immediately after birth and storing it in state-of-art laboratories in India and overseas for future use is now a convenient and affordable reality for many Indians, thanks to health companies like Cordlife India. In fact, Cordlife is the only private Cord Blood Bank in India to offer automated cord blood processing with Sepax2, a versatile patented Swiss technology. This advanced technology enables easy handling and safety of processing and aids in highly efficient and consistent cell recoveries.

Once the umbilical cord has been clamped from the newborn, the cord blood is collected from the umbilical cord vein attached to the placenta. Cord Blood extraction is not only a painless process for both mother and baby unlike bone marrow extraction, but there is a 60% higher chance of matching cord blood unit in the family vis-a-vis bone marrow. Cord Blood cells are mature, flexible and have more usage advantages than stem cells extracted from the bone marrow or umbilical blood.

After cord blood is extracted, Stem Cell Banks preserve the stem cells via Cryopreservation. Under various such methods of Cryopreservation, any damage to the stem cells caused by any enzymatic or chemical activities is prevented by cooling to very low temperatures, without further damage being triggered by the formation of ice during freezing.

Stored Cord Blood can now be available between days or weeks of processing for treatment. There is a low risk of complications when cord blood is applied for stem cell transplants and therapy since they have the ability to regenerate in the desired way.

Globally, an estimated 35,000 transplants have taken place where cord blood stem have been utilized to treat over eighty life-threatening ailments, including Alzheimer’s, Parkinson’s, bone marrow failures, genetic disorders, blood disorders and immune disorders. Several medical professionals are also researching cord blood as a potential cure for conditions that cannot be remedied presently. Umbilical Cord Blood banking is no more an option, but a necessity to secure a healthy future for the entire family.

For more details about – Why Banking Umbilical Cord Blood should be on your “To Do” List? – visit https://www.cordlifeindia.com

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The beginning of my Dad journey…

It was just past noon and whilst my lovely wife was in the bathroom, I was furiously pacing outside the door. The bathroom door opened and there she was with the biggest smile on her face and tears rolling down her rose-blushed cheeks. She was ecstatic. She waved the test and I saw that it was positive. My first thought was of pure joy and relief. I remember telling her, “can you really believe it?”, “Are you happy?”, “Does it really say that you are pregnant?” We stood in the doorway for god knows how long, hugging and crying before finally calming down.

The “moment you find out” is quite unique and it was finally sinking in. It reminds me of that singular moment in life when you hold your breath and then heave those pleasurable gasps after a chest-achingly long time. A combination of being euphoric on finding out as well as the sweet relief of the long-endured fight of trying to, engulfed us all around.

We’d been trying to get pregnant for quite some time and our gynaecologist had told us that it wasn’t going to be an easy path for us. This challenging personal experience for us was a mirror of what was happening with many of our friends and some relatives too. The entire experience of winning the battle against childlessness seemed just imbalanced. The wrongness is amplified by the sense that the act of getting pregnant should be uncomplicated and the most enjoyable thing in the world to do.

I’ve seen the tightly-managed disappointment and setback turn out to be merely the opening act for a massive emotional ocean of antagonism, hopelessness, grief, resentment, embarrassment and remorse at being envious or not interested in others’ swift stork deliveries.

But all that is in the past.

Now that it has actually happened to us, it is such an unreal feeling; something that I’ve never lived through before and doubt I ever will again. Marriage is colossal, buying a house is massive, but making a human… is mammoth. I could not wait to scream it out of the rooftop.

I started visualising what a fantastic dad I was going to be; not that I’ve had any practice before. I would need to change a million things about myself, my lifestyle, to be able to be that great dad; but I am prepared to make all those changes. No more reckless drinking and takeout every night, no more sleeping until 8:30am on workdays.

Right now, I am just excited beyond my wildest dreams and maybe a little frightened too. But today, I only want to share this joy and pride with my beautiful wife. I have no doubt that she is feeling the same thrill. After all, we did this together!

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