When a child is diagnosed with a life‑threatening genetic illness, a family’s world changes forever. The “Save the Sibling” initiative was created to bring hope to families facing such challenges—hope built on advanced science, medical expertise and compassion. This is the inspiring journey of the initiative and how it transformed the life of a young boy named Akshoy.

The Birth of a Vision With Purpose

Save the Sibling was launched as a unique collaboration between three major institutions in Kolkata:

• Renew Healthcare 
• Cordlife Sciences India Pvt. Ltd. 
• HCG EKO Cancer Centre 

Their shared mission was to help families conceive a healthy, HLA‑matched “savior sibling” through IVF and advanced genetic testing. Stem cells collected from the newborn’s cord blood could then be used to treat an older child suffering from a severe genetic disorder. This approach eliminated the uncertainty of finding a naturally matched donor.

Why the Program Matters?

Every year, thousands of children in India are born with life‑threatening blood disorders such as Beta‑Thalassemia Major, Fanconi Anaemia, Tay‑Sachs and certain forms of leukaemia. For many of these children, a hematopoietic stem cell transplant is the only potential cure. The challenge is that successful transplantation requires an exceptionally close HLA match—something rarely found outside the immediate family.

In many cases, families have had to rely on chance, hoping a future child would naturally be a match. Save the Sibling program changes this by using IVF pregnancy along with Preimplantation Genetic Diagnosis (PGD) and Preimplantation Genetic Matching (PGM). This ensures the new baby is free from the genetic disorder and is a perfect tissue match for the ailing sibling.

How the Three‑Step Collaboration Works?

1. Renew Healthcare – Creating the Savior Sibling

Under the guidance of Dr Rajeev Agarwal, Renew Healthcare performs IVF combined with PGD and PGM to identify healthy, HLA‑matched embryos. A suitable embryo is implanted, giving families the best chance of conceiving a child who can eventually help save a sibling.

2. Cordlife Sciences India – Preserving the Lifeline

Cordlife handles the collection, transportation, processing, testing and long‑term storage of the newborn’s cord blood. They also provide significant financial support, offering up to ₹20 lakhs for transplantation‑related expenses and an additional ₹5 lakhs as goodwill assistance to help families through recovery.

3. HCG EKO Cancer Centre – Delivering the Cure

Led by Dr Joydeep Chakrabartty, HCG EKO performs the stem cell transplant once the family is ready. In some cases, supportive techniques like haplo‑cord transplantation are used to ensure faster recovery.

The Mission Becomes Real Through the Story of a Little Boy Who Needed a Miracle

The Story of Akshoy: A Real‑Life Miracle

Akshoy, a cheerful seven‑year‑old boy from Kolkata, suffered from Homozygous Beta‑zero Thalassemia, a severe and inherited blood disorder. His early years were spent undergoing frequent blood transfusions—a painful routine that brought temporary relief but also carried the risk of iron overload, which can damage vital organs.

His parents were desperate for a cure. That’s when they learned about the “Save the Sibling” program.

The Journey to Save His Life

Step 1: Conceiving the Savior Sibling

Through IVF with PGD and PGM at Renew Healthcare, a healthy HLA‑matched embryo was identified and implanted. The pregnancy progressed smoothly, offering a renewed sense of hope.

Step 2: Collecting the Stem Cells

At birth, Cordlife collected the umbilical cord blood from the newborn sibling. The stem cells were processed and preserved for transplantation.

Step 3: The Transplantation

At HCG EKO Cancer Centre, the transplant was performed under the supervision of Dr Joydeep Chakrabartty. The sibling’s cord blood stem cells were infused into Akshoy, along with supportive haploidentical cells from his mother, to speed up immune recovery.

The results were remarkable. Within just 15 days, Akshoy’s immune system began to rebuild. His haemoglobin stabilised at 10.0 g/dL—healthy for his age. For the first time in years, he no longer needed blood transfusions.

A Historic Milestone for India

Akshoy’s case is believed to be the first documented instance in India where a child was successfully cured using cord blood from a sibling conceived specifically through PGD and PGM. His recovery represents a breakthrough in the treatment of genetic blood disorders and a beacon of hope for countless families.

His father expressed heartfelt gratitude, describing the journey as a blend of science, compassion, and faith. The collaboration between Renew Healthcare, Cordlife, and HCG EKO turned what seemed impossible into reality.

A Promise for the Future

The Save the Sibling initiative stands as a powerful example of what is possible when medical excellence and humanitarian commitment come together. By offering IVF, cord blood banking, and stem cell transplant services under one umbrella, the program opens new pathways for families seeking life‑saving solutions.

Every child deserves a chance at a healthy & happy life. Every family deserves hope. And through programs like Save the Sibling, hope is no longer a distant dream—it is a living & achievable reality.

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Cord blood is the blood left behind in the umbilical cord and the placenta after childbirth. The cord blood has red, and white blood cells, platelets, and plasma in it. Besides these, it has those special types of stem cells which are found in the bone marrow. These stem cells are unique, and they can mature and morph into other cell types. During a transplant, the cord blood stem cells are used to treat over 80 life-threatening diseases – blood cancers, sickle cell anaemia, thalassemia, etc. 

Many expectant parents decide on cord blood banking, during their second and third trimesters, knowing the importance of cord blood stem cells. So, once the baby is delivered, you need to decide whether you want to donate the newborn stem cells or preserve the cord blood stem cells. In this case, you’d have to choose a public or private cord blood banking system. 

What Happens in the Case of Donation of the Newborn Stem Cells?

You may consider public cord blood banks as donation centres. In this case, you may have to give away the newborn baby’s stem cells to help someone else with their treatment, or for medical research. Since this is a donation process, it will cost you nothing. However, once you donate the cord blood stem cells, you give up on the rights and ownership of the stem cells.

What Happens When You Preserve the Newborn Stem Cells Privately? 

Privately storing the newborn baby’s stem cells means saving them for the family. In this case, you only need to pay a nominal price for everything from cord blood collection to preservation and dispensation and reap the benefits later on:

Cord Blood Collection Process is Safe and Painless

Once the baby is delivered – either vaginally or emergency C – section, the umbilical cord is cut and clamped just a few inches apart. The private cord blood bank takes the responsibility to collect the cord blood in a sterile needle and cord blood collection bag. The whole thing is then taken in a cord blood collection kit box to send it to the lab for testing, processing, and cord blood banking. 

Private Banks Should Have Accreditation

Accreditations are certificates that private cord blood banks get from authorised banks for their credibility, competency, operational efficiency, as well as quality management for processing and cryopreservation of cord blood. So, Asia’s largest network of private cord blood banks like Cordlife have AABB, College of American Pathologists (CAP), WHO, etc. accreditations. 

Processing Using State-of-the-art Technology

The cord blood processing technology used by Asia’s largest network of private cord blood banking – Cordlife is the most advanced and exclusive in India. Our FDA-approved AXP® II unit ensures recovery of up to 99.8% live and potent haematopoietic and progenitor stem cells from umbilical cord blood, setting us apart as the sole provider of these vital cells in the country. Selectively preserving the newborn stem cells ensures readiness for successful stem cell transplants during any medical emergency within the family. 

Stem Cell Banking Solution

The best private cord blood banks like Cordlife prepare the cord blood samples in a way that the quality does not deteriorate. Your baby’s cord blood sample units are mixed with cryoprotectants and stored in the vapour phase of liquid nitrogen in the cryogenic storage tanks to prevent the stem cells from being damaged. The stem cells are stored under -196°C for 21 years or more, potentially for a lifetime. Ultimately, your baby’s cord blood remains your family’s property until you choose to use it. 

Provides Financial Assistance During Stem Cell Transplant

To alleviate the financial strain of healthcare expenses for your family, the best private cord blood bank – Cordlife provides financial coverage of up to Rs. 25 lakhs for cord blood stem cell therapy. This assistance is supported by an international insurer, AIA, and applies to both approved treatments and clinical trials.

Therefore, to safeguard your baby’s health and your family’s health, from over 80 life-threatening diseases, you may choose premium private cord blood banking companies like Cordlife India which will take care of cord blood collection to cryopreservation.

The post Making The Choice: Donating or Preserving Your Baby’s Cord Blood appeared first on Stem Cell Banking Guide and Pregnancy Tips For New Parents.

Since 2023, India has had the world’s most dense population, with around 1.429 billion people. 60 years ago, India was a fast-developing country. While every Indian woman can give birth to 6 children, the fertility rate descended to about 2.0, a bit below 2.0, which is required to sustain the population. 

After decades of high birth rates, India has a young population. That said, the Indian median age is 30, but 40% of the population is below the age of 25 years. Overall, there are 24 million births in India. Historically in India, there has been a large inequality between the rich and poor. This continues in the agricultural areas. However, in the industrial areas, there is a fast-developing middle class. 

There is also a notified shift in customer behaviour – their aspirational spending attitude on luxury and premium goods and services. By 2027, the Indian consumer market will be the world’s largest.  

Indian Traditions After Childbirth 

As per the Vedic religious texts, the cord blood is defined as a source of life. In some parts of India, it is the centuries-old custom to take the umbilical stump, leave it to dry, and powder it. This powder is preserved in a silver or gold amulet, often worn by the newborn. According to the old Indian cultural themes, it is believed that the child can wear that amulet to restore their strength and to treat serious illness. Additionally, there are several spiritual beliefs surrounding the practice of preserving the cord blood stem cells against regenerative medical therapy. With the progression of time, the cord blood stem cells can bring back life. 

Tāyittu is the Tamil word for amulet, which is tied around the baby’s waist, arm, and neck. According to an old study, on the disposal of placentas, a detailed account is given of what is to be done with the placenta, umbilical cord, and dried stump of the cord after childbirth. 

That means Tāyittu or amulet and cord blood bank have the same function. The belief in the healing properties of cord tissue, and cord blood, whether preserved in an amulet or stored in a cord blood bank, highlights the hope for future regenerative medicine. This belief presents a compelling case for the choice to store cord blood privately, in a community bank, or to donate it voluntarily contribution to potential future cures.

The concept of continuity of life and long-term health is a recurring theme in discussions about birthing and the use of the amulet, highlighting the cultural significance of the placenta and umbilical cord in Indian traditions. 

Following the Life Cycle of Umbilical Cord Blood Banking 

Apart from keeping the cord blood in the amulets, traditionally, in India, and the world stem cells were extracted from bone marrow or peripheral blood. 

With the advent of stem cell transplantation during the present times cord blood has been considered to be a better alternative for treatment. 

Therefore, after the delivery of the baby, the healthcare practitioner cuts and clamps the umbilical cord just a few inches apart. Then, the cord blood is collected and sent to the lab for processing and storing in liquid nitrogen in a cryopreservation tank. They are further sorted and separated into public, private, and community cord blood banks, as per the decision of the new parents. 

While in a public cord blood bank, like Jeevan’s Public Cord Blood Bank,  the new parents donate the newborn stem cells for medical, and research purposes; private cord blood banking involves extracting the cord blood unit at the time of birth, which is stored exclusively for the child. 

There is another type of cord blood bank, which is neither a completely public nor fully private cord blood bank. This type is known as community cord blood bank. 

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Learning about the self-repairing power of cord blood stem cells, there are many expecting parents who decide upon umbilical cord blood banking and bear the cost for it.  After all, thinking about the health and safety of the baby, before his or her arrival is the responsibility of an expecting parent.

And undoubtedly, they choose the best cord blood banking company.

In fact, while choosing the best, the parents-to-be would have to consider the reasons for making it the best. Out of many things like being accredited, and using the most innovative technology for processing the cord blood stem cells, the best cord blood banks choose biologically safe methods from collection to transportation, processing and retrieval.

Read this engaging article to know how:

Safe Collection Process

The baby may be born vaginally or via an emergency C – section, once the baby and the placenta is delivered, the cord is disinfected and the vein is punctured to clamp and cut it a few inches apart. Then the caregiver inserts a sterile needle and collects the blood left behind in the umbilical cord and the placenta in a sterile collection bag. This bag, in fact, is kept is safe condition inside an x-ray free certified collection kit box, which again filled with anti-coagulant, thus preventing the blood from clotting, before it reaches the laboratory. 

Safely Designed Transportation Container

Basically, the collection kit box is coated with hard plastic, and has vacuum insulation in it. It is designed in this way, so that temperature is properly maintained and that the temperature is absolutely under control, when the sample cord blood unit is getting transported to the lab or the transplant center, even during harsh weather conditions. 

Biologically Safe Processing Labs

The baby’s cord blood and tissue are processed in a biologically safe, clean environment and well-equipped labs. 

Safe Transportation Facility

The best cord blood banking company takes the complete responsibility to deliver the sample in time and in good condition at the transplant centre for final usage. In fact, the logistic partners with its best-controlled measures ensure absolutely safe and timely delivery of the sample unit. In case the stem cells are found to have been damaged during transportation from storage facility to the transplant centre, we either offer an alternate matching sample or a compensation. 

Safe and Advanced Storage Methods

For future testing, the cord blood is stored in a 25ml multi compartment cryobag with integral segments. In fact, some private cord blood banks keep the baby’s stem cells in frozen state (-190 Degrees), so that, the stem cells can be preserved anywhere between 21 to 75 years of a baby’s life.  

To Conclude

As compared to the other cord blood banks, who give no assurance on the maintenance or who give no surety of safety or timely transportation of the sample unit to the transplantation center, Cordlife India, the largest network of private cord blood bank in Asia, is safe.

All that the clients need to do is pay a nominal price to keep their baby’s cord unit safe with Cordlife for 21yrs or more and enjoy exclusive ownership and accessibility throughout the tenure¬ and retrieve it when there is need for transplantation. 

The post How Do You Know That A Cord Blood Bank Is Safe? appeared first on Stem Cell Banking Guide and Pregnancy Tips For New Parents.

Parents worry – it’s just part of the job. Whether you’re a first-time parent, one with adult children, or even one with grandchildren, you’re constantly worrying. So, it is only natural that the coronavirus pandemic has added one more fear to your list – could it affect your little one? While research about the impact of COVID-19 on babies and children is still underway, there are some precautions you can take to make sure your baby is safe.

How Can You Identify Coronavirus in Babies?

The symptoms in babies are mainly similar to those in adults, albeit slightly milder. These can include fever, runny nose, sneezing, and gastrointestinal issues like diarrhea. Symptoms are likely to materialize about a day or two after being exposed, but it’s possible for some babies not to show any symptoms. How would you know then? Unfortunately, you wouldn’t unless a family member tests positive, requiring your baby to be tested too.

Do You Need To Be Worried About Your Baby Catching The Virus?

You’ll be happy to know that fewer babies and children are getting sick from the virus, and if they do, they do better than most adults. However, infants below the age of 1 are more likely to fall critically ill.

It has been noted in a published study that out of 2,100 children who tested positive in China, about 4% had no symptoms. 51% had mild symptoms, and 39% had moderate symptoms. Only 6% had a severe attack. Of these, most were infants. Despite studies, researchers haven’t concluded why children are more likely to have milder symptoms when compared to adults. Some have credited it with higher levels of antibodies or different immune responses.

Can Babies Pass The Virus On To Others?

The virus is mainly known to spread via respiratory droplets that get into the air when an infected person sneezes or coughs. With that said, babies and young children can spread COVID-19 in the same way.

Can Babies Contract the Virus From Their Infected Mother?

While research is still on, it has been noted that transmission between an infected mother and her unborn child is very unlikely.

Can Babies and Children Get The Vaccine?

While most people worldwide are racing to get their jab, the approved vaccines are only limited to adult use. It will likely be many months before any vaccine can be administered to young children.

It’s normal if you still feel helpless against the virus. However, parents or not, most people are in the same boat. The only way you can keep yourself, and your baby safe during the pandemic is by following these steps:

Always Wash Your Hands

Remember, wash up for 20 seconds with soap and water, or use a hand sanitizer if you can’t get to a washroom.

Social Distancing

If you have to step out, keep your child at home with a healthy caregiver to avoid them coming into contact with anyone.

Mask Up in Public

Wear two masks – a cloth mask over a surgical mask for maximum protection. Do note that children under 2 have been advised to avoid wearing a mask due to suffocation concerns.

While there’s nothing that can calm a worrying parent, make sure you follow these guidelines to lower the risk of the virus hitting too close to home.

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Muscular Dystrophy (MD) is a genetic condition that causes the muscles in your body to weaken and degenerate over time. There are several types of Muscular Dystrophies that can occur, like Becker’s Muscular Dystrophy, Limb-Girdle Muscular Dystrophy, etc. Of these, Duchenne Muscular Dystrophy (DMD) is known to be the most fatal one. However, researchers are exploring novel techniques like stem cell treatment to alter the genetic mutations causing the illness and improve the patient’s quality of life.

What Happens in Duchenne Muscular Dystrophy (DMD)?

This condition occurs when there are mutations in the dystrophin gene that code specific muscle proteins. Dystrophin is responsible for the proper functioning of the muscles, and the lack of it can cause the muscle fibres to be in disarray and degenerate. As a result of improper functioning of the muscles, there is progressive and rapid muscle weakness and loss.

The Dystrophin gene found in the X-chromosome affects men, while most women only remain dormant carriers of the gene. Hence, the condition is typically passed on from either parent to the child. However, in some cases, this is due to a new, spontaneous genetic mutation that occurs during pregnancy.

What Are The Signs of DMD?

The muscle weakness caused by this condition starts manifesting during early childhood days. Delay in achieving developmental milestones like sitting, walking, and even talking are signs that the child could be suffering from DMD. The condition usually starts with a loss of strength and function in the pelvis and thigh region, followed by the arms. The child has trouble standing up as a toddler and loses mobility by the time they are teenagers. Increased convex curvature of the spine and change in gait are also noticeable signs of DMD. Even the heart and lung functions are affected due to the weakening of the muscles in the region, causing breathing and other issues for the child as they grow older. This leads to a respiratory or cardiac failure by the time the patient reaches their twenties.

Future of DMD Treatment With Stem Cells

Although there is no cure for DMD at present, the advancement in medicines, gene therapy, stem cell treatments, etc., are providing greater hope for patients to live longer and feel better.

Ongoing research indicates that mesenchymal stem cells (MSC) can help relieve the DMD symptoms by aiding muscle cell regeneration and repairing damaged muscle cells. Since umbilical cord stem cells are at an early development stage, they can take the form of any cell. Therefore, using Umbilical Cord Mesenchymal Stem Cells (UCMSCs) increases the muscle cells’ functionality and replenishes the stem pool.

In a study conducted on mice by a team of Harvard Stem Cell Institute researchers, the outcome looks promising. The researchers transplanted healthy stem cells into the muscles of mice with muscular dystrophy and observed that these new cells improved the damaged muscles’ functions and made them contract. They also noticed that the healthy stem cells replenished the diseased stem cell pool, which could repair any damage to the muscles during future injuries.

This study further demonstrates the potential of stem cell therapy in treating patients with muscular degeneration caused by DMD or other types of muscular dystrophy. The banking of stem cells can prove to be a blessing for your family as well as the field of medical science.

The post Muscular Dystrophy: Can Stem Cell Treatment Help? appeared first on Stem Cell Banking Guide and Pregnancy Tips For New Parents.

Autism is not a disease that can be cured with medication. Instead, it is a condition where the individual requires support, care, and understanding of others. So, in this month dedicated to Autism, let’s take some time to understand it and sensitize ourselves to the needs of autistic individuals.

What Is Autism?

Autism Spectrum Disorder or ASD is a blanket term used to describe patients with various neurodevelopmental problems. The symptoms of this condition start appearing right from the early days of a baby’s life. Sometimes, as early as 12 months of age. These children have difficulty in interacting socially and communicating and may also display repetitive behaviour.

In some cases, the patients are entirely dependent on their caregivers to perform day-to-day functions, while others may function independently. Hence, parents need to identify the symptoms of Autism in their children and start early intervention to overcome some of its challenges.

What Causes Autism?

While the cause for Autism is still not fully known, many experts believe that the following reasons can be responsible for the condition:

• Genetics
• Viral infection during pregnancy
• It runs in the family
• Low birth weight of the baby
• Imbalance of metabolism
• Prolonged exposure to environmental toxins

Several other factors are being studied to understand the exact reason for Autism in children.

What Are The Symptoms Of ASD?

Most children with ASD start displaying the symptoms right from infancy. However, there are also cases where the symptoms show up later on in their childhood.

The symptoms of this disorder are divided into 2 broad categories, and they are as follows:

Communication and Social Interaction Problems

• The child may have difficulty maintaining a conversation, expressing their emotions or feelings, etc.
• The child will have trouble making eye contact or understanding non-verbal communication like hugging.
• The child may find it challenging to make friends or other relationships with peers or family members.
• The child will have delayed speech development.
• The child may prefer to play alone rather than with other children.

Restricted or Repetitive Pattern or Behaviour Problems

• The child may exhibit repetitive movements, actions, or speech patterns.
• The child may get agitated if his/her routine is changed or broken.
• The child may react negatively to loud noises or bright lights, or other specific sensory information.
• The child will exhibit unusual behaviour like lining up toys or keeping them in a particular way.

Some Other Characteristics That A Child With Autism Spectrum Disorder May Exhibit Are:

• Flapping hands, rocking the body back and forth, or spinning in circles.
• Aggression or tantrums when things don’t go their way.
• Limited attention span.
• Talking in limited words or not using gestures.
• Getting agitated easily.
• Not responding to their name or mommy’s voice.

How Can Autism Be Treated?

Although there is no cure for ASD, several therapies ease the symptoms and improve quality of life.

• Speech therapy to improve your child’s communication skills
• Behavioural therapy to improve their social skills and manage their aggression
• Physical therapy to improve their motor skills and co-ordination
• Meditation therapy to help them relax and stay calm
• Occupational therapy to improve their day-to-day living by teaching them basics like brushing their teeth, toilet training, dressing, etc.

While these therapies aim to make the Autistic child more independent, the treatment for the condition involves high vitamin supplements, chelation therapy to remove any metals in their body, melatonin medication to improve sleep quality, etc. The doctor administers these treatments after carefully studying the patient’s condition and history. As the field of medical science progresses, the treatment options for Autism will also hopefully increase. Presently, researchers are studying the Stem cell banking benefits to cure Autism. However, it is too early to see any concrete results.

Let’s stay positive and focus on giving the autistic child all the love, care and support needed to have a happy life.

The post A Closer Look At Autism And Its Impact appeared first on Stem Cell Banking Guide and Pregnancy Tips For New Parents.

Autism is usually described as a spectrum disorder because the signs, symptoms, and abilities are different for each patient. And it can be tough to diagnose initially. Most kids with ASD apparently have a usual infanthood and parents are unable to detect any significant warning sign. They sit, crawl, eat, and sleep like any other baby. Autism, in most cases, gets diagnosed only after 18 months of age, when social differences start getting noticed. Hence, parents need to keep an eye out for certain early signs to get their little ones help on time.

Early Signs of Autism in Babies

• Babies usually make eye contact by the age of 2 months. So, make a note if your baby is above two months of age and still unable to make eye contact.
  
• Babies usually start following an object with their eyes if you point at it. If they are not doing so, it might indicate autism.
  
• By the age of 6 months, babies recognize their own names and often respond when their name is called. If a child doesn’t respond when their name is called even after 9 months, it could be a warning sign.
  
• Often a pattern of non-response is noticed in a baby with autism.
  
• Lack of emotion in facial expression is another red flag. An autistic kid doesn’t necessarily feel less emotion, but they are unable to express it through facial expression.
  
• Delayed speech is another sign. If a child is not saying a single word by 16 months or has not started saying double-letter words by the age of 2 years, it is better to consult a doctor.
  
• Regression is a major indicator of autism using human stem cell. Most autistic babies start losing the skills that they had learned once. For example, they stop babbling, or making eye contact, or forget pointing at objects. Some toddlers pick up few words but gradually stop using them.

Now, since parents and caregivers are often unable to recognize the early signs, most kids get diagnosed after they turn two. So, seek medical help if you notice any of the following social or behavioral problems:

• Prefers to play alone
• Does not share toys
• Interacts less
• Lack of facial expressions
• Resists physical contact
• Does not understand personal boundary
• Has difficulty understanding or expressing feelings
• Avoids eye contact
• Repeats the same phrase over and over, also known as echolalia
• Interacts in a robotic manner
• Displays repetitive behavior like rocking, spinning, flapping hands etc.
• Loves routine and gets upset when the routine is broken

How to Deal With Autism

Depending on the condition of your child, various therapies can help you in dealing with the disorder.

• Cognitive Behavioral Therapy (CBT)
• Behavioral Management Therapy
• Social Skills Training
• Speech Therapy
• Diet Modification
• Occupational Therapy
• Medicine
• Stem Cell therapy

Stem Cell therapy is a brand-new ray of hope for autism. Stem cell banking benefits conditions like cerebral palsy already. So, inspired by that, scientists have started researching cord blood banking and its subsequent use for treating autism. The immune modulator capacity of stem cells can restore autism–immune alterations. In simple words, they can replace the malfunctioning cells and replace them with healthy cells. Therefore, stem cell banking can be an effective method of treating autism.

The post What Signs Show That Your Child Is Autistic? How to Deal with It? appeared first on Stem Cell Banking Guide and Pregnancy Tips For New Parents.

Getting ready to have twins? It’s going to be double the joy and also double the work. You might have already spoken to your doctor about the various complications you may encounter in your pregnancy. You may have also discussed the care you need to take. However, have you asked your doctor about cord blood banking?

If you haven’t, then this article will help you understand how cord blood banking can help your twins in the future.

Why Is Cord Blood Banking Important?

The blood from your baby’s umbilical cord is a rich source of hematopoietic stem cells. These potentially life-saving stem cells have the ability to transform into red or white blood cells or even platelets. Therefore, it is widely used in treating patients suffering from disorders of the blood, immune system, metabolism, etc. Currently, there are over 80 diseases that are being treated using cord blood cells, including certain forms of cancer. With the advancement of medical technology and knowledge, researchers believe that the number of treatable diseases will only increase. Another fantastic fact about cord blood cells is that they can be used to treat the donor’s immediate family members. Since these umbilical cord blood cells are at a nascent stage, there is a lesser chance of Graft-Versus-Host-Disease where the recipient’s body rejects the newly infused stem cells.

This opens up a plethora of opportunities for treating any future illness your baby or his/her twin may develop.

Can Cord Blood Banking Be Done For All Kinds Of Twins?

It doesn’t matter whether your twins are Fraternal (where the fetuses grow from two separate eggs) or Identical (where the fetuses grow from one egg and split into two at a later stage). You can still do cord blood banking for both and safeguard them against any health issue that may arise in the future.

Why Bank The Umbilical Cord Blood Of Both The Babies?

Since fraternal twins don’t share an identical genetic build, there is a possibility that one can inherit a genetic disorder while the other doesn’t. In such cases, the healthy twin’s cord blood cells can be used to treat the other as it’s the closest possible match. Although identical twins start with identical genomes, certain environmental factors can influence and change how these genes shape up. Hence, one of your identical twins may grow up to develop a genetic disease while the other may not.

Your body naturally produces enough blood to nourish and nurture both babies, even when they share a placenta. However, since twins generally tend to be smaller in size and share the space in a womb, the volume of blood available for collection is relatively lower. Don’t be disheartened! As each baby has an individual umbilical cord attached to them, there is enough cord blood collected from each and cryopreserved at a private cord blood bank. Public cord blood banks operate similarly to public blood banks and hence, cannot be retrieved as and when required.

Simply put, when you bank the stem cells of both your babies, you maximise the treatment opportunities for themselves and their sibling for years to come. So, don’t let this golden chance go to waste.

The post Things To Know About Cord Blood Banking For Twins appeared first on Stem Cell Banking Guide and Pregnancy Tips For New Parents.

During pregnancy, the umbilical cord acts as a “String of life” between the mother and the baby and connects the baby to the placenta. In fact, the baby gets its all-necessary blood or oxygen and nutrition to survive in the mother’s womb, from the placenta through the cord.

Earlier, after the baby’s delivery, the umbilical cord with the cord blood was treated as medical waste. With the advent of cord blood stem cell therapy, the scenario has changed.

Cord Blood Composition and Medical Uses

Research has it that, cord blood is a rich source of haematopoietic stem cells, which has the capacity to differentiate itself into different blood cells – Red Blood Cells (RBC), White Blood Cells (WBC), plasma and platelets. The cord blood may largely be driven by haematopoietic stem cells, but other important non-haematopoietic adult stem cells types like Mesenchymal stem cells (MSC) and Endothelial Progenitor cells are also present in it with its multipotent properties. Mesenchymal stem cells (MSC) among them, may be found in lesser amounts in the cord blood compared to what it has been found in the bone marrow, placenta, and adipose tissue; but it is known for its immunomodulation and differentiation abilities. In fact, Mesenchymal Stem Cell therapy has evolved as a strong contender in the fight against the deadly effects of Covid-19 virus.

Cord Blood Stem Cell Transplants

The treatment of Fanconi Anaemia, way back in the year 1988 is still considered the first successful cord blood stem cell transplant. But that’s not all. Researchers have seen quite a number of successful transplants or cellular therapies across many countries around the world till date. In fact, cord blood stem cells have proven themselves instrumental in treating over 80 life-threatening diseases such as cancer (lymphoma and leukaemia), inherited metabolic disorders and deficiencies of the immune system. However, research on umbilical cord blood stem cells being used to combat neurological defects like cerebral palsy, autism, and Alzheimer’s are gradually gaining momentum.

Banking the Baby’s Umbilical Cord (therefore) Can Be a Life-changing Decision

Yes! Of course. There are banks (Private and Public) who respect this decision and take all the necessary steps from the collection to cryopreservation of the baby’s cord blood. In some cases, parents donate their baby’s cord blood to Public Banks, for research work or to help others, but they can’t use it for themselves. Some parents choose private cord blood banking companies so that they can reap the benefits later on.

Cord Blood Banking Benefits

Safe, and Painless Collection

Once the baby is separated from the mother, after the baby’s delivery, the hospital staff cuts and clamps the cord a few inches apart from the baby and uses a sterile needle and bag to collect the umbilical cord blood.

Approximately 75 ml of the cord blood gets collected. And without causing any pain either to the mother or the baby, the cord blood left behind in the cord and the placenta gets easily collected and transported to the lab for processing, quality testing, cryogenic-preservation and dispensation as and when required.

Innovative Technology

Ensures absolutely no possibility of manual inaccuracy, and the highest possible recovery of the stem cells, while processing the cord blood.

Proper Storage For A Successful Transplant

If the baby’s cord blood stem cells are properly cryopreserved, or kept in a frozen state (-190 Degrees) anywhere between 21 to 75 years of a baby’s life, it means that the baby or his or her family can use the stem cells for treatment even after two decades.

Close Match Within The Baby’s Family

Before an umbilical cord blood stem therapy begins, the first step is to match the stem cells with the donor and recipient. There is 60% chance of matching within the baby’s family and his or her siblings. If, by chance, the cord blood stem cells are not genetically matching, there is a high chance of grafts-versus-host-disease complication after the transplantation.

Haematopoietic stem cells may not be pluripotent like embryonic stem cells, but it is being studied with the hope for using beyond blood and immunological disorders. Moreover, along with cord blood, Wharton’s Jelly and Cord Lining have been researched for mesenchymal stem cells (MSC) and is studied in vitro since 2015 for heart disease, neurological defects and immune and other organs (liver and kidney) disorders. Even cancer. Above all, umbilical cord blood banking allows parents to gain access to cutting-edge treatments for themselves and their family’s healthy future. And more and more parents nowadays are including umbilical cord blood banking in their birth plans.

The post Know Everything About Umbilical Cord Blood and Cord Blood Banking appeared first on Stem Cell Banking Guide and Pregnancy Tips For New Parents.

Creating an embryo or sperm with the help of stem cells from any part of the body may seem like something out of a science fiction movie or novel. However, research suggests otherwise.

At present, stem cells are being used to treat a wide range of diseases that range from Leukemia to Sickle Cell Disease. The regenerative properties of stem cells are why researchers are hopeful that it can help treat reproductive disorders one day. Although there haven’t been any human trials to study stem cells’ effectiveness in forming an embryo or sperm, there have been mice trials that have been highly successful.   

In a study¹ conducted at the Kyushu University in Fukuoka by a team of reproductive biologists led by Katsuhiko Hayashi, they were able to produce mouse eggs from the skin cells taken from an infertile mouse under laboratory conditions. Using a process known as re-programming, they turned these skin cells into Pluripotent Stem Cells (a type of cell that has the ability to transform into any cell, including an egg or sperm). This research yielded fertile pups from these eggs, made inside a petri-dish, which were pushed towards fertilization. This process is known as In Vitro Gametogenesis (IVG) and increases the possibility of having babies for couples using the cells of their liver, blood, or skin.

IVG is a massive development in Assisted Reproduction Technologies (ART) as it offers hope for many couples who are unable to bear a child due to dysfunctional gametes. Due to changing lifestyles, stress, environmental factors, etc., there is a steady rise in infertility cases. Hence, more and more couples are turning to alternative therapies and treatments as they long for their genetic offspring. IVG is a ray of hope even for same-sex couples who would otherwise have to look for a donor. It is also possible to use IVG for people who suffer from an absence of gametes due to conditions like PCOS, ovarian cancer, other ovarian diseases for women and nonobstructive azoospermia, or chemotherapy for cancer in men.

Although promising, the use of stem cells in reproductive therapies is far from perfect. The study² also reflected that only 3.5% of the embryos implanted were able to grow into healthy mice, while 18% of the stem-cell-derived eggs showed an unusual number of chromosomes. This anomaly could have led to genetic disorders in the pups. Hence, researchers are delving into this topic with utmost caution. Especially, when the stem cells are embryonic ones or those from the umbilical cord blood and cord tissue

Apart from research moving forward at a slow pace, there are also some reservations surrounding the ethical and legal boundaries that need to be set around its use. Some argue that prospective parents may create multiple embryos only to select the best of the lot or an individual may use the technology to create an offspring from the cells of another individual without their consent or knowledge.

With so many implications and conundrums surrounding stem cells’ use to create embryos, it’s only best to wait and watch the developments. The day is not too far where infertile couples will be able to cradle their genetic offspring with the help of science.

Sources:

1. eurostemcell[dot]org/reproduction-and-fertility-how-could-stem-cells-help
2. sciencemag[dot]org/news/2016/10/mouse-egg-cells-made-entirely-lab-give-rise-healthy-offspring

Reference Links:

1. parents[dot]com/pregnancy/giving-birth/labor-support/alternatives-to-epidurals-during-labor/
2. cordlifeindia.com/blog/scientists-developed-fertilized-eggs-mouse-stem-cells/#_ftn2

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It’s not easy for most women to talk about the most intimate parts of your body and your life. So, whether you’re planning to have a baby or have just found out that you’re pregnant, you need to find the right gynecologist for you. How do you do that? Here are some tips:

Recommendations

Consult your family and female friends before zeroing on a gynecologist. When you ask them for recommendations, you will get first hand information about their skills and experience.

Reviews

Once you get the names of a few gynecologists, check their reviews online. From this, you will also understand how many patients they have, along with their personal experience. Watch out for low ratings and reviews as it can be a red sign for you.

Experience & Credentials

When you’re searching online or consulting friends, find out about how long practised, which hospitals they’re associated with, their speciality, their qualifications, and if they have any malpractice suits filed against them.

Insurance

Pregnancy and delivery is a costly affair, and hence you’ll need to know if the hospital that the gynecologist practices in accepts your insurance.

Shared Values

Your gynecologist is going to be the one who will advise you on birthing options, ultrasound scans, and everything about your pregnancy. Hence, it’s important to understand if your ideas and opinions about the same match. Even if it doesn’t match, you need to know whether you can trust her advice.

Comfort Levels

Your gynecologist will be getting very personal with you when it comes to your body as well as your personal life and reproductive health. It would help if you were comfortable enough to talk to this person about everything for your pregnancy to go smoothly.

Gender

Because you’re going to talk about your personal life and preferences, you need to figure out if gender matters to you. If you’re not comfortable discussing these intimate topics with male gynecologists, you must choose a female doctor. You wouldn’t want to put yourself and your child at risk because of experiences you wouldn’t be able to discuss with your doctor.

Hospital Quality

Research the hospitals that your doctor is affiliated with. You need to understand the quality of care at the hospital and the facilities as well. Location is also an important factor when it comes to you getting to the hospital on time. Remember that your gynecologist is going to be an important part of your pregnancy and delivery team. Make sure you find someone who you trust and are comfortable with. Just knowing that you are satisfied with your doctor is half the battle won for a happy and smooth pregnancy.

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The umbilical cord is a connection between mom and her baby that begins well before the baby is born. Whatever the baby needs for survival inside the womb reaches him/her via this cord. Not only does it supply blood to the developing fetus, but it also carries essential nutrients to the womb.

The Make-up of the Umbilical Cord

The umbilical cord is a rope-like structure with a thin exterior covering called Wharton’s jelly that attaches itself to the centre of the placenta. It contains two tiny arteries and a vein. The job of these blood vessels is to supply adequate blood and oxygen to the growing fetus and to transport necessary nutrients from the placenta. The umbilical cord grows up to 50 centimetre in length and 2 centimetres in diameter during the pregnancy. The cord also consists of stem cells that can be used for treating various life-threatening diseases like cancer and anemia. Parents have the option of cryo-preserving the cord blood cells in private cord blood banks to be used later if needed.

The umbilical cord is usually coiled up resembling a spring inside the womb. This allows the baby to move around without any resistance. Once your baby is delivered, the cord-cutting is done almost immediately. It is a painless process as there are no nerves in the umbilical cord.

The Various Components Of the Umbilical Cord and Their Functions

Arteries: The main role of the two arteries is to carry blood from the baby to the placenta. Along with the blood, they also carry carbon dioxide and other waste products. The arteries close soon after delivery to prevent blood loss to the placenta.

Vein: This carries oxygen from the red blood cells in the mommy’s body through the placenta and to the growing baby. It also carries essential nutrients needed for the baby’s development. The vein takes a little longer to close, generally around 3-4 minutes. Hence, delayed cord clamping allows more nutrients to be passed on to your baby even after birth.

Cord Blood: The umbilical cord contains excess blood which the baby doesn’t require after being born. This cord blood contains elements of regular blood along with potent stem cells that can be used to treat 80 diseases. These stem cells can be harvested and preserved by cryogenically freezing them for future usage. Your baby’s umbilical stem cells can be used to treat diseases in any of his/her immediate family members. This is because the cord blood contains the most primitive form of stem cells which can adapt to a new host body. The chances of the new body rejecting the umbilical cord blood cells (Graft-Versus-Host-Disease) is relatively low.

Once your baby is born, and the cord has been cut, there will still be a stump left behind. This stump will dry in due course and eventually falls off on its own. Mommy has to make sure the stump is kept clean and dry to prevent any infection in the baby. Once the stump has fallen off, the baby’s navel will appear in the exact same spot.

The post Understanding The Umbilical Cord appeared first on Stem Cell Banking Guide and Pregnancy Tips For New Parents.

Doing umbilical cord blood banking for your baby provides an assurance & a piece of mind. However just like any insurance it is imperative not to trust the words of a salesman, but to validate the assurance yourself. If you thinking of securing your new-born’s precious cord blood stem cells with a cord blood banking company, you should look into a number of aspects before zeroing down on a company. Apart from checking the company’s experience in terms of years in the business, Companies financial condition (as we are talking of a relationship which is 21 years and beyond), national & international accreditations and technology you should keep in mind is the agreement you sign with your cord blood banking service provider.

Afterall, it is the agreement that binds both the parties (you and your brand) throughout the tenure of the storage and thus a start of a long journey or a relationship begins.

In this article we provide you with a comprehensive guide with regards to the important aspects that your cord blood banking agreement should entitle:

Sample Processing and Preservation

While taking the cord blood banking presentation, whatever quality standards was committed with regard to the collection of the cord blood should be specifically mentioned in the agreement. The technology that is being used to process of the cord blood should be clearly mentioned. If the Company is providing advanced technology which will have minimal or no human intervention, as this will help in retaining the maximum viability and potency of stem cells should be considered. Ensure that this is categorically mentioned in your agreement.

Who Remains the Custodian Of The Stem Cells and Till When

Generally, the mother will get the right of the baby’s stem cells until the baby turns major. After which, the right of the stem cells will be transferred in the baby’s name.

Journey of Your Sample From Storage Center to Transplantation Center

In case there is a requirement for transplantation, the retrieval and transportation of stem cells is an expensive affair. It is always desired that the company should take complete responsibility of the transportation of the stem cells. The liability of the company should end only once the transplant center or the doctor confirms that the stem cells which is delivered is good enough for transplant. Additionally, the duration within which the sample should reach the transplantation center (domestic and international) should also be specified in the agreement.

If the stem cells lose its potency when it is checked at the transplant center, then the company should be liable and committed to provide an alternative matched sample within the agreed timeframe. Inability to procure the same should claim for compensation.

Financial Expenses For Transplant Programme Should Be Covered

Any transplantation cost, is a significant burden on parents. Ensure that, the agreement not only mentions that the treatment cost is covered but the cord blood banking agreement should clearly specify the name of the insurance provider. 

Diseases Covered

Please read the insurance clause minutely to find out what are the diseases which are covered in the insurance. We are doing cord blood banking because the treatment options for stem cells is growing day by day. The diseases/ conditions which are currently under research/ clinical trials may become a reality tomorrow. So the gamut of conditions under financial assistance should cover most of the treatments under clinical trials and not only the diseases which are currently approved. 

Members Covered

Agreement should also clearly define the members of family who would be covered for getting the benefits. 

Add On Services Are Always a Plus

A cord blood company offering services like HLA Typing and CFU Assay, Expansion of Umbilical cord blood, provision of Supplementary sample or additional matching or bonus unit are beneficial for parents and should be clearly documented in the agreement. 

Schedule of Fees

You agree to pay the fees and charges set forth on the Schedule of Fees attached within the agreement.

Feasibility of Assurance

We have to be judicious enough to understand the feasibility of the value-added services offered. None of the private cord blood banks across the world are Ngo’s. all of them are here to make profits. Ask for the feasibility & logic for services which does not look logical or practical. 

Addendum

Please refrain from choosing the company which commits you to provide change of clauses or adds new clause’s/ benefits through an addendum. Such kind of addendums may not hold good in the court of law, as the “Authorized Signatory” cannot change for the addendum. 

Cordlife agreement covers these and even more vital points. We pride ourselves in having one of the transparent agreements in the Cord blood banking industry and honoring each and every clause that is mentioned in the Cordlife agreement. Therefore as parents before you zero down on the cord blood banking company whom you will entrust to secure your baby’s precious stem cells for more than two decades, we tell you why Cordlife, a brand known for its premium-ness should be your first and only choice.

The post Things To Look For In A Cord Blood Banking Agreement appeared first on Stem Cell Banking Guide and Pregnancy Tips For New Parents.

While it may seem like a lifetime ago, the pre-COVID era saw many pregnant women happily planning their delivery day. After all, it was going to be the day that they’d welcome the newest member of their family. However, once the pandemic hit, everyone was sent into a tizzy. With the uncertainties and lockdowns, came a fear that gripped every pregnant woman around the globe – how would their delivery be impacted during these unprecedented times.

While there are signs of improvement, and also a ray of hope on the horizon, mommies-to-be are still reeling in a cloud of ambiguity. There’s a lot of uncertainty about what will happen when you arrive at the hospital. To help you, we’ve listed out 6 things that you need to be prepared for before you go into labour in the COVID-age:

Hospital Room Bookings

Due to the scarcity of beds, many hospitals are forced to turn away patients, even those seeking emergency care. Be proactive and check-up on bed availabilities at nearby hospitals according to your due date. This will save you time and effort when you actually go into labour.

Hospital Companion

Most hospitals have implemented strict policies when it comes to the number of caregivers allowed per room. Even though it is put in place to curb the spread of the SARS COVID19 Virus, it can be troublesome for a first-time mom. Choosing between your partner or your parents at such a time could be really difficult. Just think about what each one brings to the table and make your decision based on what is it that you will really need help with for a couple of days after delivery.

Social Distancing and Sanitization Protocols

New and stricter norms are in place regarding social distancing and sanitization. Avoid crowded places and wear a mask at all times. If you are visiting the hospital for your routine check, try to reach at the time of your appointment and not earlier. In this way, you won’t have to be in the hospital longer than required. If you are sharing a room, then make sure that you sanitize your hands and the toilet seat before and after using the washroom. Carrying your own water bottle is also a good idea. Also, wash all fruits thoroughly before you take a bite.

Added Expenses

Hospitals may demand a deposit at the time of admission, which may be steeper than pre-Corona days. It is advisable that you keep aside money for the hospital deposit as well as for COVID19 tests and other screenings which would not have otherwise been a part of the delivery charges.

The Virus

Being informed is essential. Pregnant women must make themselves aware of the proper ways to care for themselves and their little ones during these times. Being mindful of the symptoms of COVID19 like fever, fatigue, chills, nausea, headache, etc. is crucial to help you identify and get the treatment early. In case you are tested positive for the virus, then what are the possible ways to avoid transmission to the baby is something you should speak to your doctor about beforehand.

Virtual Support

Being isolated from your family and friends with a baby to take care of can be overwhelming. Hospital staff too, might not always be around to help you. It might get exhausting, and you may even have doubts if you are doing things right. However, use the gift of technology to your advantage. Video call your mother to ask for advice or ask your friends to sing a lullaby for your baby. It will help you stay in the right frame of mind.

Now that you’ve gone through the list, we hope that you feel better prepared for D-Day. Don’t let it overwhelm you and don’t hesitate to ask for help when you need it.

The post 6 Things You Need to Know About Giving Birth During Covid19 appeared first on Stem Cell Banking Guide and Pregnancy Tips For New Parents.

When Mr and Mrs. Conn realised that their daughter Georgia was struggling to see or play like other children, they got her diagnosed immediately. There are numerous families like the Conn Family who have children suffering from cerebral palsy in their house. The parents may notice their children are failing to reach their age-wise developmental milestones like rolling over, crawling or walking. But, by the time they start looking for safe treatment options, it is already very late.

So, What is Cerebral Palsy?

According to Can Child, “Cerebral palsy (CP) is an umbrella term used to describe a disorder that results from perinatal brain injury.” ^[2] This kind of brain injury arising out of the hindrance in foetal development or due to compromised oxygen supply at the time of birth are known to be some of the primary reasons for developing such a condition, like cerebral palsy. Babies suffering from this condition have problem in moving, communicating and learning.

The type and severity of cerebral palsy symptoms depends largely on the depth of the brain injury and may vary from person to person. While some children in this condition may need life-long care, others may manage living their lives with mild disabilities and minimal support.

Is There a Cure Available for Cerebral Palsy?  

Unfortunately; till now there has been no specific cure found for cerebral palsy. But, with early intervention and a combination of right therapy like exercise, speech therapy, etc. and medication, the outlook of these children can be significantly improved. The good news is, with the advent of regenerative medicine, treating Cerebral Palsy with umbilical cord blood stem cell therapy has shown a promising outcome in several cases. ^[4]

Why Umbilical Cord Blood is a Hope?

Umbilical cord blood is a rich source of haematopoietic stem cells which have the capability to renew and differentiate into different types of blood cells – Red blood cells (RBC), White blood cells (WBC) and Platelets. In case of children with Cerebral palsy, the brain imaging scans have shown lack of blood flow in the various regions of the brain leading to damage. In order to address this defect, the ability of umbilical cord blood to renew and repair these damaged parts has been taken into consideration in numerous clinical trials that are going around the world.

Cordlife Group has released 19 cord blood samples and 3 cord tissue samples to treat cerebral palsy. Several clinical trials going on across the world, have considered various parameters and published that the cord blood treatment is not only safe for treatment children with cerebral palsy but has also shown positive improvements by addressing the core damage and leading to subsequent results in symptoms.

Develops New Blood Vessels

The deficiency of oxygen may damage the blood vessels, thus cutting off the blood flow and oxygen supply to the brain. This results in significant death of the brain cells and impact the respective activities controlled by the damaged region of the brain. Cord blood known to have Hematopoietic stem cells has the ability to develop new blood cells and developing of new blood vessels will help in the blood flow and oxygen supply, thus repairing and enabling gradual improvement in function of the child.

Repairs the White Matter

Any damage in the white matter of the brain, which controls the voluntary actions, may lead to under-developed gross motor skills. In this case, early intervention with umbilical cord blood with neuroprotective properties helps restore the white matter.

Repairs the Grey Matter

An injury to the grey matter, essentially cuts off or limits communication between the areas of grey matter of the brain, involved in muscle control, and sensory perception. Due to which a child may not be able to see or speak properly. Infusion of cord blood with its regenerative properties may help in repairing the grey matter and thus enabling the child to initiate its functions.

Strengthens the Muscles

Damage to the brain may also impact the function of the muscles thus negatively impacting the control on balance, movement and co-ordination in the child. With the infusion of umbilical cord blood, the activities of muscles are stimulated and improved

Improves the Immune Function

The infusion of the umbilical cord blood has also been found to have improved the immune function.

Marked improvements observed after the Stem Cell Therapy within 6 months to 1 year

• GROSS MOTOR FUNCTION
• IMPROVED EFFECTIVE USE OF THE AFFECTED HAND
• POSITIVE CHANGE IN NUMBER OF CONNECTIONS IN THE BRAIN
• POSITIVE IMPROVEMENT IN DEVELOPMENTAL FUNCTIONING OF INFANTS AND TODDLERS
• POSITIVE CHANGE IN MUSCLE STRENGTH
• POSITIVE INCREASE IN COGNITIVE ABILITY
• OTHER CHANGES:

General behavior
Parental Impact-Emotional
Temperament and Moods

Researches on umbilical cord blood stem cells being used to combat disorders like cerebral palsy are   gaining momentum across the globe. Therefore, banking the baby’s umbilical cord at birth is being considered by many parents as a responsible step towards securing the baby’s health and future. Umbilical Cord Blood is collected immediately after a baby is delivered. Once the baby is separated from the mother, the cord is clamped and the blood along with the cord tissue is collected and transported to the laboratory for further processing and cryopreservation.

The post Treating Cerebral Palsy with Umbilical Cord Blood appeared first on Stem Cell Banking Guide and Pregnancy Tips For New Parents.

With every passing day, more and more parents are realizing the importance of storing their babies’ cord blood. After all, the stem cells present in the Cord Blood have the power to cure critical illnesses like metabolic ailments, blood disorders, immunity problems and certain cancers in the future. Essentially, they can be life-saving. However, before you decide to sign up for cord blood banking, here are 5 questions that you should ask.

Is the company stable and profitable enough to sustain for 21 years and beyond?

Choose a company that has been in the business for a long time, preferably for decades. Large companies and big brands, which are pioneers and have operations in various countries, are stable as well as trustworthy. They are profitable enough to sustain themselves for a long time.

Benefits of banking with big companies:

• Unmatched commitment, transparency, superior quality services and peerless expertise.
• Just sign-up with a trusted brand and your baby’s cord blood will be safely stored and you will have complete rights and access too.
• The exclusive advantage of comprehensive stem cell banking is that it allows the storage of epithelial cells along with hematopoietic and mesenchymal stem cells.
• All-inclusive protection is offered to the entire family for different medical treatments.
• A large collection of stored and released cord blood demonstrates the company’s experience and expertise. Such a company is trusted by a large number of parents and has an excellent history of client satisfaction. These factors ultimately are an assessment of the company’s business stability.
• If a company participates in biotechnology research, it is another positive sign of its strength.

What are the accreditations of the company?

Accreditations ensure that best practices and rigorous quality control standards are followed by the company for cord blood and tissue collection, processing, storage and distribution. These accreditations are done by international quality assurance organisations and local governing regulatory bodies. Some of the relevant accreditations are:

• American Association of Blood Banks (AABB), which confirms compliance with US Federal laws
• Drug Controller General India (DCGI)
• College of American Pathologist(CAP), which ensures compliance with testing standards

Choose a company where audits are conducted at appropriate intervals to conform to the stringent guidelines. Such companies are reputable and trustworthy and guarantee the utmost safety in stem cell preservation. Often, such companies are recipients of awards that recognize their high quality and innovations in technology. They are often honoured for their excellent customer satisfaction policy, which is built on trust and transparency.

What is the technology used for processing the cord blood & tissue?

Go for companies that use cutting-edge technology to ensure the maximum recovery of viable stem cells. Such companies often use exclusive patented technologies and processes invented by renowned scientists. Usually, the characteristics of good technology are:

• Laboratory Accreditations: Certifications from international quality control organizations like FDA, AABB etc.
• Use of innovative technology and quality control protocols: This ensures accuracy and reliability
• Automation of processes: Zero possibility of manual inaccuracy, thereby giving consistent and reliable results
• Safety and sterility of the processing unit: Entirely closed and perfectly monitored processing unit to eliminate errors and cross-contamination

Are you insured for future transplants & which company is insuring you?

Choose a stem cell insurance policy that is comprehensive and covers the cost of treatments for which stem cell transplants are the protocol. In that case, the cost of matching and ensuring the viability of stem cells is also covered. If, at the time of transplant, the stem cells lose their potency, the insurance provider will find a match or offer monetary compensation.

Some of the best insurance companies provide other benefits too. They might cover the treatment cost of pregnancy, and delivery complications and offer family coverage. They might also waive storage costs in case of disability or death of a spouse and cover expenses related to medical malpractice. Thus, such umbrella coverage will give you and your entire family complete mental peace.

What happens if the stored stem cells are destroyed?

In case the stored stem cells get destroyed, the company should guarantee either of these two choices:

• Replacement of the cord blood, if you need it, without any charges
• Appropriate monetary compensation

Since going for cord blood banking is an important decision and something that concerns your baby’s future and well-being, it is natural to have many questions. As parents before you zero down on the cord blood banking company whom you will entrust to secure your baby’s precious stem cells for more than two decades of his life.   Why tell you why Cordlife, a brand known for its premium-ness  https://www.cordlifeindia.com/blog/brand-known-premiumness-cordlife/  should be your first and only choice.

The post Thinking About Cord Blood Banking? Expect these answers to your Questions appeared first on Stem Cell Banking Guide and Pregnancy Tips For New Parents.

Nearly half a million people, from across the world, seek medical help for accidental burns and are hospitalised in severe conditions. These are fatal burns, often causing death. However, there are many other kinds of burns, which may leave the patients physically disabled for their entire lifetime.

What Are Burns?

Burns are therefore, accidental skin cell damages brought on by fire, chemicals, electricity or radiation, leaving the skin:

• terribly pained,
• swelled and
• charred.

Treatments for burn wounds depends upon the type of the burn and how deep it is covering the body.

Conventional Burn Wound Care

A medical health practitioner always follows the thumb rule of cleaning the burnt area first with cool water and then applying gel upon it. *2. However, use of autologous skin grafting technique was the first known severe burn wound treatment, reported in 1881. Until now skin grafting technique happens to be a standard practice to treat severe burnt cases.

Earlier, in severely burnt cases (full-thickness burn or 3^rd degree burn, which damages the epidermis and the entire dermis), doctors discarded and considered the burnt skin to be a medical waste. However, since it contains viable MSCs (burnt-derived Mesenchymal Stem Cells), that can be used for skin regeneration and wound-healing, in present times these cells are characterised and expanded in vitro, which is then incorporated into an established wound coverage material.

Introduction of Cell-based Burn Wound Therapy

In is interesting to know that the culture of cell-based therapy for burn wounds was first introduced after Rheinwald and Green, revolutionised the cell culture technique in 1975. So, for the very first time, clones of some of the major cell types was used during an autograft, where epithelial sheets of cells were produced to restore the functional capacity of the skin.

Research Activities on Burn Wounds Cell Therapy

Such an encouraging report gave rise to worldwide research activities on cell therapy for burn wounds healing process. *4 For example, a Singapore-based biotech company Cell Research Corporation, carried out a test which involved growing stem cells on synthetic scaffolds, preventing three burn victims from undergoing the painful process of skin grafting. Several tissue engineering approaches have been applied in skin-tissue fabrication and tissue substitute including autologous split-thickness skin graft. Autograft micro-skin transplantation has been widely used as skin-graft therapy in full-thickness skin defect.

Aim of Cell-based Therapy In Burn Wound Care

The effectiveness of stem cell therapy in burn wounds have already been tested earlier. With further examination, the stem cell therapists ultimately aimed to see:

• If these cells have the capacity to reduce the effect of the systemic inflammatory response and stop the infection from spreading
• An easy and early wound closure
• Speedy healing
• Regeneration of the skin and its peripheral tissues
• See if the potential usage of Epithelial stem cells (EpSCs) with an effective application of Mesenchymal Stem Cells (MSCs), derived from the umbilical cord and cord blood, covers the wound and completes the healing and skin regeneration process.

Epithelial Stem Cell Therapy on Burn Wound Cover

To prove an early and efficient wound coverage along with the satisfactory epithelialization, cultured epithelial autografts, (EpSCs and keratinocytes combined) is used to facilitate cell delivery with the aim to regenerate the epidermal layer of the burned skin.

But there are several factors that limit the potentially of this technique:

• the time necessary to culture cells
• the reliability of graft ‘take’
• the vulnerability to infection,
• long-term durability, and
• the cost of the treatment.

Mesenchymal Stem Cell Therapy For Burn Wound Healing

Post-burn injury wound healing is of paramount importance and allogeneic mesenchymal stem cells (MSCs) is one of the potential treatments for severe burn injuries:

• MSCs can grow easily
• They can maintain the tissue culture
• They can migrate to support the endogenous cells
• Additionally, its immunomodulation capacity allows it to withstand acute cellular rejection, especially in massive burnt wounds

However, researches state that when burn wounds are treated with allogenic MSCs, the recovery is speedy and there are no adverse treatment complications.

Future Directions

Clinical studies demonstrate that cell-based therapy can be considered as an important alternative for burn wound management. However, there are still certain scientific and technical factors that need to be resolved before full potential of the cellular devices are facilitated. In the meantime, more evidence is required for research at large to define the clinical efficacy and safety of cell therapy in burns.

The post The Use of Stem Cells in Burnt Wound Treatment appeared first on Stem Cell Banking Guide and Pregnancy Tips For New Parents.

Cordlife is the oldest and having the largest network of Cord blood banks in Asia pacific. We are a Singapore-based health care company, catering to the mother and child segment. We take immense pride in ourselves in being trusted by millions of parents to secure their baby’s umbilical cord blood across the continent. We are also considered as a premium cord blood banking company in India. There are several features we offer that are unique only to Cordlife. Here are some out of the many reasons why Cordlife should be your One Chance One Choice to bank your baby’s stem cells.

We Have a Heritage

Cordlife started as a pioneer in cord blood banking company 19 years back in Singapore. Since then, we have slowly and steadily expanded ourselves to becoming the largest network of cord blood banks in the Asia-Pacific, present in 10 countries. Following our legacy, we started our operations in India at Kolkata in 2008, and gradually spread our wings across the country. Now we operate in 210 cities across India. With almost two decades of in-depth knowledge and expertise in stem-cell banking, we have carved our niche and have built a distinguished brand name in the sub-continent, including India. We can swear by our quality, transparency and commitment to our clients and stakeholders.

We Are Internationally Recognised

Since our inception, our capabilities in maintaining high standards of trustworthy and reliable cord blood banking services have been well-recognised by some of the established quality standard organisations as well as government regulatory bodies. Our state-of-art lab facility, located in Kolkata, has been licensed and accredited by National and International bodies – Drug Controller General India (DCGI), American Association of Blood Banks, College of American Pathologist and World Health Organisation (AABB, CAP and WHO), thus proving that we do not compromise on our quality at any cost.

Also, we are proud of our global accolades across around two decades. To begin with, in 2007, the World Economic Forum validated our outstanding performance in the industry by bestowing us with the prestigious “Technology Pioneer” title. We have been awarded “The Most Transparent Company” by SIAS in 2013 and were recognised by Forbes (Asia) in 2015, amongst the Top 200 “Best Under a Billion” companies in Asia Pacific.

We Use Advanced Processing Technology

The baby’s cord blood and tissue are processed in a biologically safe and clean environment maintained inside the well-equipped labs of Cordlife. However, we are the only company in India to use the most advanced technology of AutoXpress II to process cord blood and harvest high numbers of Mono Nucleated Cells MNC & CD34 and the globally patented CellOptima^TM technology to process the cord lining and with validation of the functional capacities of the tissue stem cells.

We Offer Total Stem Cell Banking Solution

If collecting and cryopreserving stem cells at the time of delivery is the only chance, then storing both cord blood and tissue is what Cordlife offers. All that our clients need to do is pay a nominal price to keep their baby’s cord unit safe with us for 21yrs or more and enjoy exclusive ownership and accessibility throughout the tenure. It not only gives you the benefit of getting a 3^rd cell line – Epithelial Cells, in addition to the Haematopoietic Stem Cells & Mesenchymal Stem Cells (EpCs, HSCs and MSCs), but also offers you with a total stem cell banking solution and complete protection for your entire family under any treatment condition.

We Give the ‘Value’ We Get Paid For

For any transplant, if the stored sample of cord blood is not suitable for use, may be due to genetic defect, human leukocyte antigen (HLA) mismatch or shortfall of the sample, then there is nothing to worry about. As a part of the Total Stem Cell Banking Solution, we offer access to samples from over 50 public repositories across the globe and cover our clients with a bonus or supplementary sample without having to lose exclusive rights on their own sample.

We Provide Complete Transportation Liability

Cordlife is the only company in India which takes complete responsibility to deliver the sample in time and in good condition at the transplant centre. In case the stem cells are found to have been damaged during transportation from storage facility to the transplant centre, we either offer an alternate matching sample or a compensation.

We Provide Insurance Covered Medical Assistance

In order to ensure that our clients get the financial coverage for the cord blood transplant, we have an insurance back up underwritten by AIA for approved treatments as well as approved clinical trials, using both stored stem cells or stem cells sourced from public banks.

The Cordlife Quality Warranty

This is unique only to Cordlife. Our warranty is the only guarantee in India, and we ensure that cord blood stem cells are  replaced  at no additional cost within 14 business days or compensated up to INR 2 million, should the cord blood loose its viability at the point of transplant and matching HLA is not to be found from the repositories.

One Chance and One Choice

Still thinking? Fret not! As Cordlife is more than just a cord blood bank. With an aim to give 360-degree protection for the baby and the entire family, we always try to remain at the forefront of science. So, don’t miss this once-in-a-lifetime opportunity. This is your one chance to secure your baby and your family for a healthy future.

The post A Brand Known For Its Premiumness- Cordlife appeared first on Stem Cell Banking Guide and Pregnancy Tips For New Parents.

FREQUENTLY ASKED QUESTIONS

SAFE COLLECTION, TRANSPORATION, PROCESSING & STORAGE OF CORD BLOOD

DURING COVID-19

Worried about sample collection during COVID-19 outbreak?

CORDLIFE is with YOU in this LOCKDOWN

COVID-19 pandemic has almost shut the entire world. Whole nation is under lockdown because of this outbreak of Novel coronavirus. But Cordlife is committed to serve you as per its best services that we always offer. With special permissions and exemption for essential healthcare services, our sample collection team is operational PAN India to serve you. Because we are liable to keep our promises. And we will surely put our best foot forward to serve you during this critical period, and following the government regulations at the same time.

STAY HOME! STAY SAFE!

We shall deliver our necessary customer service digitally.

For any other assistance, we are available on 18001216200 and 98301 66200. You can also write to us at info@cordlifeindia.com and we will get back to you.

Meanwhile, to address some of your concerns we have drafted a short list of FAQs that will build help you get a glimpse of our commitment and build your confidence on our services during this hard time.

Collection

1. I can deliver anytime. Whom should I contact for the collection of sample?

You can call at our helpline 1800 121 6200 (Toll free) or 98301 66200, minimum 4 hours before the delivery. We will assign a paramedic for the collection at the time of requirement. We have ensured that our paramedics are available round the clock so that collection process is not impacted.

 SAVE THESE NUMBERS ON YOUR MOBILE! We are just a call away!

Note: You can contact our local representative who completed your documentation formalities, to make the arrangements. And also, the contact numbers of our paramedics are mentioned on the Kit Box handed over to you.

2. How will your paramedic reach hospital for collection in this lockdown?

As we are enlisted under essential healthcare services, our paramedics are exempted from the lockdown restrictions. Along with that our paramedics have been provided with exemption passes wherever required to ensure they reach hospital on time for the collection and deliver the kit box to the nearest logistics point for pick up and transport to our lab.

Logistics

3. Will the sample reach on-time to your lab?

All the transportation needs of our paramedics have been taken into account to make sure they can reach the logistics point safely and timely ensuring arrival of the sample on-time in our lab.

4. How will the sample reach your lab in this lockdown?

We have taken utmost care for the logistics so that your sample will be transported special cargos moving via multiple routes for the fastest possible delivery to our lab along with all the safety measures that need to be taken while transportation.

Processing and storage

5. Will you start processing the sample as soon as it reaches the lab in the given time-span in which the sample needs to be processed?

Our lab is 24×7 serviceable. Therefore, you don’t need to worry about your sample. As soon as your sample reaches our lab, our team will take-up your sample immediately for processing. All necessary requirements for processing and storing your sample have been adequately procured.

6. How can you assure us that proper hygiene and safety measures will be followed in the entire process from collection at hospital to storage of the sample at your lab?

Cordlife is committed to you to provide its best service. And when it comes to maintaining safety and hygiene Cordlife is liable to maintain its quality of hygiene through the entire process from collection of the sample to storage at our lab.

Let’s have a brief look on the entire process.

• At collection- Cordlife ensures the paramedics are healthy with no symptoms of health conditions. At the time of collection of the sample, all government guidelines are followed and proper hygiene & sanitization is maintained. Our paramedic team is provided with PPE kits , Masks, Goggles & sanitizers to be protected from any possible infections.
• In logistics- Once the collection has been done, the collection box is securely sealed. Cordlife’s kit box is single-use, and cannot be reused. This prevents the possibility of exposure to infections. The Kit Box once closed is vacuum sealed and not only maintains temperature but also prevents interaction with external environment. Additionally, it is subjected to external disinfection during transit and also once your sample reaches our lab, before opening the box and taking the samples for processing.
• At the time of receiving– As soon as any kit is delivered at the Laboratory reception, the Kits are sterilized from outside with disinfectants. After disinfecting the kits from outside, then the kit is opened one by one & disinfected from inside. Each Kit is opened one at a time for added protection. After complete sterilization of the Kit, it is then shifted to the lab for processing.
• At the time of processing and storage- Cordlife lab is well-equipped and proper hygiene and safety measures are followed in the entire processing and storage of the sample. All the lab equipment’s are cleaned and disinfected frequently to avoid any kind of contamination.
• Lab staff’s hygiene and safety- At Cordlife we ensure that all our lab staffs are screened through thermal scanner. Moreover, government guidelines are strictly followed by all the staff prior to entering into the lab premises and during the time of work.

 Customer queries

7. Who will address my queries in this lockdown?

Keeping in mind the safety of our employees as well as our clients, our customer support team is operational from their home. They have been provided with necessary infrastructure to access work from home and you can be rest assured all your queries will be addressed. There may be instances of delay in response. But emergencies are attended on priority.

Your support and understanding would help us serve you better.

Payments

8. How can I make the payment during lockdown?

We have provision for making online payments and you can do so through our website https://www.cordlifeindia.com/payment-gateway. Due to the current lockdown, any other mode of payments in the form of cheques/demand drafts in this lockdown period may not reach us on time. Hence there may be delay in acceptance and acknowledgement of payments made through offline form till the time things are in control. So it is recommended that you make all your payments through online mode.

In case of any query or assistance needed, please call us at 1800 121 6200.

The post FAQ – Collection of Cord Blood During COVID-19 appeared first on Stem Cell Banking Guide and Pregnancy Tips For New Parents.

Cordlife Celebrating Women’s Day – Dr. Vandana Sharma Jamshedpur .

Cordlife Celebrating Women’s Day – Dr. Seema Todi Jamshedpur, Jharkhand

Cordlife Celebrating Women’s Day – Dr. Anju Bajoria Jamshedpur Jharkhand

Cordlife Celebrating Women’s Day – 

Dr.Shilpita Banerjee

Cordlife Celebrating Women’s Day – Dr. Deepa Balani – Jodhpur

Cordlife Celebrating Women’s Day – 

Dr.Monica

Cordlife Celebrating Women’s Day with

Dr. kirti Gaur

Cordlife Celebrating Women’s Day with

Dr. Lovely Jethwani

Cordlife Celebrating Women’s Day with

Dr. Nayanika Gaur

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Holi, the most vibrant and colourful festival in India is just around the corner. A perfect time to have fun  and some colourplay with friends and family . Amongst all the fun, additional precautions need to be taken by moms to avoid any harm to your children as well as yourselves. Would-be-moms need to be extra careful while dealing with colours. Exposure to harmful chemicals, water and consistent sunlight might not only cause damage and tanning, but also have some long term undesirable side effects, which could take some time to heal if not taken care of early.  A few tips that would help you take necessary precautions for your family without diminishing the joy of the festival.

wishing a safe holi 2020 WITH full fun & frolic from codlife with some skincare & haifcare tips

Pre Holi Skin CARE Tips

• Apply a mixture of Almond & Coconut Oil not only to your face but also entire body, before you step out. Do not forget to apply an extra layer of Almond Oil beneath your eyes. The Oil not only protects the skin from harmful effects of colour but also ensures easy removal of colours post play.
• Apply Sunscreen with high SPF 30 to add a second level of protection to your skin and act as a barrier from the possible effects of long term exposure to Sun.
• Colours make the skin dry. Apply a lip balm or Vaseline to keep them moist and protect from direct contact of harsh chemicals.
• Do not forget to give an extra base coat of nail polish.
• Drink & Hydrate yourself with water and juice since harsh chemicals dehydrate your skin, as they penetrate deep to your Skin.
• Choose herbal and organic colours which are devoid of any toxins or harmful substances

Wear Sunglasses to add some style and at the same time protect your eyes from the sunlight and colours.

Pre Holi Hair CARE Tips

• Do not shampoo the day before Holi, such that your natural hair oil is retained.
• Massage your hair well the night before Holi. Apply Almond & Coconut Oil or any suitable hair oil, evenly. The Oil will help prevent the harmful colors from seeping in and also help you get rid of harsh colours, later.
• Adding a few drops of lemon juice to the oil and preheating before applying, helps shield your scalp against any infections.
• Do not keep your hair open and play Holi. It is advisable to make a bun or tight ponytail to protect your hair from the effects of the harsh chemicals.

Special Precautions for Would-be-Moms

• Avoid going to crowded places. You may get hurt in the crowd or even have trouble breathing in such places.
• Avoid playing in areas with water. It may be of high risk to you. While playing Holi with water, the ground gets slippery and may cause you to slip accidentally. So you need to be extra careful and stay away from such places. And you may also catch a cold. Aatchuuuu….
• Avoid any outside food or drinks. Usually Holi is celebrated in most complexes or societies and serve deep fried foods, ladoos, lassis etc. Many a times, substances like bhang is added, which is well known during Holi. But it is important to know that such components can cross the placenta and reach the baby in the womb and are not known to be safe for the baby. Would-be-moms suffering from gestational diabetes or overweight should especially avoid holi sweets completely. In case you are unable to control the temptation, you may have healthy snacking options in your kitchen.
• Play minimally that too with organic colours. You may make your own colours with flower petals, vegetable juice and avoid playing with chemical colours. The chemical substances in synthetic colours may cause harm, so it is better to avoid them altogether.

Play Holi. Have Fun. Be Safe.

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Participants will have to answer a set of Questions (10 questions) related to Cord Blood. The questions will be available on the Blog Page. The format will be Multiple-Choice Questions. 3 winners will be chosen.

1st Prize – Amazon Gift vouchers worth Rs.2000 (1 Participant)
2nd Prize – Amazon Gift vouchers worth Rs.1500 (1 Participant)
3rd Prize – Amazon Gift vouchers worth Rs.1000 (1 Participant)
Consolation Prizes – Amazon Gift vouchers worth Rs.500 (5 Participants)

T&C Winner Selection Procedure

• All the answers has to be correctly answered.
• Cordlife employees can participate, but not eligible for Gift vouchers.
• The contest ends on 22nd November 2019 at midnight 00:00 hrs.
• Correct answers will be published on 23rd 2019 on Cordlifeindia Facebook Page.
• Winner selection will be done via Lucky Draw on 25th 2019.

The post World Cord Blood Day Quiz Contest appeared first on Stem Cell Banking Guide and Pregnancy Tips For New Parents.

To avail the Offer, Store Your Baby’s Stem Cells at The Time of Delivery with Cordlife India.

Cordlife customers can avail 50% discount on complete range of Certified Organic mother & baby care products from Life & Pursuits.

 Terms & Conditions:

• The promo code is applicable for order value of Rs 500 and above.
• A promo code will be valid for 2 months once offered. No further extension will be provided for the redemption of promo code.
• The promo code can be used only once per customer.
• The offer is limited to one order per promotional code.
• This offer cannot be clubbed with any other promotion offered by Life & Pursuits.
• The order will be dispatched within 3 working days and will typically reach customer in around 7 days.
• These Terms & Conditions can be changed at any time at the sole discretion of Life & Pursuits.

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The blood that remains during birth in the umbilical cord is called cord blood. This blood is normally discarded. However, cord blood bank uses amenities to store and preserve a baby’s cord blood. If you are considering to store the cord blood of your baby, be sure to use a cord blood bank accredited by the American Association of Blood Banks (AABB).

The cord blood of your baby is an abundant source of HLA matched stem cells for your baby and family. Stem cells are pluripotent cells as they help to develop all body tissues, organs, and systems.

Stem cells can transform into other types of cells in the body to create new growth and development. They are the building blocks of the immune system as well. The transformation of these cells provides a way for doctors to treat leukaemia and certain inborn health disorders.

The stem cells collected from the baby’s cord blood can also be effective in treating certain diseases or conditions of a parent or sibling. Stem cells extracted from the umbilical cord blood have similar ability as bone marrow to treat the disease, with less rejection. Banking a baby’s cord blood and stem cells in a cord blood bank is a type of insurance. You may need to access your baby’s stem cells for treating any kind of medical illness. However, using a cord blood bank can give you peace of mind when you know that you have a valuable resource if you need it.

Cord blood collection process is safe and painless as it is done after the birth of the baby. It usually takes less than five minutes to complete the whole process. Cord blood collection does not disrupt the process of delivery and it is possible collect in case of both vaginal and caesarean deliveries.

Cord blood can only be collected during the first 15 minutes of birth and is kept in the storage bag covered with cooling pads. It is then sent to the laboratory within 72 hours for further processing. The baby’s cord blood is processed and stored in a lab called a blood bank. This processed cord blood is stored in a bank which had been accredited by the American Association of Blood Banks (AABB) to store the stem cells.

Cord blood banking usually involves two fees. The first is the initial fee for enrolment in the company and the second fee is taken for the collection, processing and storage of the sample. However, this structure of fee differs according to different company which you will come to know after you go through the details of the pricing of a company.

As a leading of all the private cord blood banking companies, we had dedicated ourselves from last 18 years in serving the people of Southeast Asia. With our corporate office and laboratory in Kolkata, we are the only company using AXP®II technology for processing the cord blood. We are the only company providing stem cells of all the three lines which includes haematopoietic, mesenchymal and epithelial cell lines.

Our offers are unique such as to provide supplementary sample where there would be a mismatch with the required and the stored sample; providing alternate sample when the sample that is stored cannot be used due to detection of traits for genetic diseases; and providing additional sample, if there is a shortage of required sample.

Last but not the least if you are willing to secure the heath of your baby as well as the family then you can opt for our services and enjoy the benefit of exclusive rights to own your sample.

The post Provide Health Security by Saving Your Baby’s Cord Blood appeared first on Stem Cell Banking Guide and Pregnancy Tips For New Parents.

“A mother’s love for her child is like nothing else in the world. It knows no law, no pity; it dares all things and crushes down remorselessly all that stands in its path. – Agatha Christie”

 It’s an auspicious day of celebrating a bond between the mother and the baby. It is celebrated on the second Sunday of May in most countries including the United States, Australia, Canada and India. Despite of difference in the date for Mother’s Day in the world, the feelings never change.

It is time to appreciate and give exclusive attention on Mother’s Day to the pregnant lady.

The baby that grows strong and beautiful inside you has a heartbeat and is your baby. The world may not have a connection with this little life, but you do. You’re his mummy. You’ve been worrying about every little movement or lack of it; wondering what it looks like; dreaming about and thinking upon names for your precious bundle of joy; making sacrifices to ensure that she is as healthy and safe as possible.

If you and your better half decide to announce your pregnancy to friends and family soon— think about doing it on Mother’s Day. Couples traditionally maintain their mother’s pregnancy until after the first trimester, where the risk of miscarriage declines. But spreading the news before the 12-week mark, even as soon as they get that big fat positive, is becoming common for moms-to-be.

“Whatever you decide to do on this Mother’s Day, be sure you celebrate, you Mama! Celebrate Mother’s Day while pregnant! You are very much a mother and this day is for you just as much as it is for the Mama of 2 children.”

The post Celebrate the Feeling of Becoming Mother on the Mother’s Day! appeared first on Stem Cell Banking Guide and Pregnancy Tips For New Parents.

Cordlife Mother’s Day Contest

Contest for: Mothers and Expectant Mothers

Contest Details:

Participants (Mothers) will have to write and post about their take on Motherhood and how they feel being a mother with a picture with their children. Participants (Expectant Mothers) will have to write about what they feel about motherhood with a picture. All the participants should post their entries on Cordlife India Facebook Page with hashtags – #CordlifeIndia, #MothersDay #Motherhood and have to share the post on their Facebook wall.

Winners (3 mothers and 3 expectant mothers) will get Amazon Gift voucher worth Rs 500.

The contest will end on 20^th May 2019 midnight at 00:00 Hrs.

Terms and Conditions:

 Like Cordlife India Facebook Page.

• Post all entries (50 words minimum with picture) on Cordlife India Facebook Page and share it on your Facebook wall.
• Use #CordlifeIndia and #MothersDay #Motherhood with your post.
• Winners will be decided based on the maximum number of post engagements (Likes, Comments and Shares) received by a participant.
• Contest ends on 20^th May 2019 midnight 00:00 hrs.

Winners selection with be done on 24^th May 2019 & will be notified Via Facebook direct message.

The post Mother’s Day Contest appeared first on Stem Cell Banking Guide and Pregnancy Tips For New Parents.

Holi is indeed a fun festival. However, the real challenge comes right after Holi when you have to struggle with the after effects of color on your skin and hair. Here are some tips that can protect your skin and hair to a great extent from the damages of colors used during Holi.

 Post Holi Skin Care

• Take a shower as soon as you reach home. The longer you let the colours dry and set in, the more difficult it would be to get rid of dry colors. You need to stand under running shower for 5-10 minutes.
• Shower with Luke warm water and liquid soap. You may add glycerin and sea salt to this mixture. This will prohibit any infection from toxic colors.
• Do not rub your facial skin too much while removing the Use oil-based cleanser to remove them. You may also use a mixture of curd and sandal wood for your face. This mixture works wonders to cleanse your skin. You may also dab some olive oil on your face and wash off with Luke warm water after few minutes.

• To hydrate after taking bath, apply moisturizer in your face and skin.
• However, do not worry in case there are traces of colors left on your skin as it will take a few days before finally fading away completely. Do not exfoliate your skin with scrubs at least for 48 hours after playing Holi.

Post Holi Hair Care

• Wash your hair normally with plain water to get rid of the colors naturally. Place your scalp under a steady flow of water for some time.
• Use a herbal Shampoo to get rid of colors.
• To moisturize your hair use a hair mask using olive oil, lemon juice and a curd Apply the mask on your hair and keep the mixture for 30 minutes. Wash off with mild shampoo and conditioner.

It is advisable to wash yourself carefully in case you are a lactating Mother. You may use ubtans made up of olive oil, curd, besan and take the bath with Luke warm water. Otherwise your baby may be affected by ingesting colors.  With a little Caution and Care Holi can be enjoyable for all the Moms-to-be and New Moms.

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2^nd April is recognized every year as the World Autism Awareness Day by United Nations in order to spread awareness about the disorder throughout the world.

Autism Spectrum Disorders (ASD) is a neurodevelopmental disorder that affects the communication and behavior of the individual. This disorder may occur at any age, it is mostly diagnosed in the initial years of the baby and persists into adulthood. Due to absence of any medical test like a blood test, diagnosing ASD can be difficult. Observing a child’s behavior and development is the only way to diagnose and is sometimes detected at 18 months to 2yrs of age¹. However, many children do not receive the final diagnosis they need for therapeutic intervention.

Characterized by the presence of restricted interests and repetitive behaviors, affected individuals encounter social problems mainly facing difficulty in communicating and interacting with people, and is much more common than many people think. 1 in 160 children² has an autism spectrum disorder (ASD). As inferred from a CDC study in 8yr old Asians, the prevalence of Autism Spectrum Disorder, was found to be 1.35 in every 100 children^1,3, with an occurrence of about 4 times more among boys than among girls¹. The American Academy of Pediatrics recommends that all children be screened for autism³.

Currently there are no medications available that can cure ASD or treat the core symptoms. According to reports by the American Academy of Pediatrics and the National Research Council², behavior and communication approaches like Behavioral analysis, Occupational therapy, Speech therapy, Sensory Integration therapy are some of the currently employed treatments that help children with ASD are those that provide structure, direction, and organization for the child in addition to family participation. The goal of treating an autistic individual is to maximize your child’s ability to function by reducing autism spectrum disorder symptoms and supporting development and learning.

However, several clinical trials⁴ are being carried out worldwide in renowned institutes like Duke University and Sutter Institute for Medical Research (SIMR) using cord blood⁵, giving hope to many families to relieve the symptoms of autistic patients to a certain extent and allow them to be as independent as much as possible. Autologous cord blood stem cells, banked at the time of birth, when used for transplant are not only seen to be safe⁵ for the patient but also showed significant improvements in children behavior in measurables like social communication skills⁶, vocabulary and children attention to social stimuli³. The paracrine activity⁷, i.e. the ability to release bioactive molecules that quickly traffic to the site of inflammation along with the immunomodulatory properties⁷ of umbilical cord stem cells make them a promising treatment option in future.

Banking one’s newborn’s cord blood stem cells at the time of birth can be best security one can provide to both the baby and family members, if needed in future. These stem cells are the 100% match for the baby and the best possible genetically close sample available for the family members.

To know more about cord blood stem cell banking, call us at 1800 121 6200 and book your presentation today.

The post Autologous Cord Blood Stem Cells – a Promise for Autism Spectrum Disorder appeared first on Stem Cell Banking Guide and Pregnancy Tips For New Parents.

There was a huge growth in the cord blood industry during the period of the mid-late 2000s. Through the past few years, the cord blood market had become compact and matured. In addition to North Asia and Southeast Asia, the growth had been also seen in North American as well as the European countries. As the cord blood industry has significantly matured throughout the world, so there are some opportunities and threats that are laying impact on the industry.

If you are thinking that how there can be any threat for such a useful process of cord blood banking? Then it can be said that

“YOU KNOW NOTHING”

and there are lots of threats that include:

• Low consumption rate of the cord blood units which are stored.
• The cord blood transplantation is an expensive procedure.
• Requirement of accreditation increases the cost structure of the cord blood banks. To obtain an industry accreditation a cord blood bank needs a huge expense.
• Cord blood has now become the most expensive products in the market which has led to the increase in the market pressure on the companies.
• The competition in price is another threat because there are many competitors offering discounts in their price plans.
• Other factors of threat are continuous requirement of accreditation, natural calamities that can harm the infrastructure, inadequate knowledge among the people about cord blood banking and many others.

In addition, there are some opportunities too:

• HLA mismatch transplants become less as the stem cells are used from the family.
• Occurrence of GVHD becomes less and now-a-days it becomes easy to treat GVHD.
• Increase in the regulatory pathways for stem cell transplantation.
• Clinical trials on stem cell therapy are ongoing to approve more diseases that could be treated by stem cell therapy.
• Improving the knowledge of stem cell therapy among common people.

The post Opportunities and Threats Laying Impact on Cord Blood Market appeared first on Stem Cell Banking Guide and Pregnancy Tips For New Parents.

To allow your bundle of joy to achieve a healthy birth, you need to be careful and follow safety and nutrition tips to stay healthy for yourself too. When you are through your pregnancy stage, it is crucial you do not engage yourself into something, which could be harmful for you and your baby. Here’s going the most essential pregnancy and safety tips.

Prenatal Vitamin Is Mandatory

An intake of prenatal vitamins and nutrients are important, even when you are just planning to conceive. This fosters the development of the neural cord in the baby within the first month of pregnancy, which transforms into the brain and the spinal cord later. Hence, it is essential you take important vitamins and nutrients from the early stage of pregnancy, including folic acid, iron and calcium.

Your obstetrician can help you find the right amount of these vitamins and nutrients. If it feels like queasy, you can take with a light food, or take them during bedtime.

Workout

A moderate level of workout comprising a brief walk or some free hand exercise is a better option to stay healthy during pregnancy. Don’t overdo it, and make sure you do it only for 15-20 minutes in a cool shaded area to avoid overheating. There is a gamut of health benefits for a healthy pregnancy, which improves your mood, reduces stress and regulates your weight.

It is important you take your doctor’s advice before going for any workout regimen during pregnancy.

Don’t Smoke

Smoking is always detrimental for you and your unborn baby. As it facilitates the development of preliminary breathing distress in you and also in your baby, you should always follow an abstinence from it. Remember, even a passive smoking or second hand smoke could be damaging. While smoking is unhealthy, so is the alcohol during pregnancy. Be concerned and sane, stay away from the clutches of smoking and drinking.

Make Changes to Your Daily Chores

During pregnancy, it is important you do not do anything, which can put your baby and you at risks. With each day passing by, even the regular types of chores, including scrubbing the bathroom or watering the plants can draw some challenges to your pregnancy health. There are chances that you can come in contact with the harmful bacteria or toxic chemicals. So, you must put some chores out of your to-do-list. They are as follows as the below:

• Climbing the ladder or stepstools
• Standing near a hot stove for a long period
• Heavy lifting
• Using toxic chemicals

Increase the Intake of Folate Rich Foods

Drinking as many as 8 glasses of water is essential. With this, it is crucial you add to your diet folate rich foods. Incorporate them in five-six well-balanced meals during your pregnancy. The diet can include foods like lentils, oranges, tangerine juice, fortified cereals and asparagus. The consumption of folic acid ensures your baby develops a healthy neural tube and also immune system.

Eat Lots of Fish

Fish contains omega 3 fatty acids, an important component for the brain development. In a study in 2007, it reported that the children of mothers, who ate the most fish during their pregnancy, developed higher intelligence quotients than children of mothers, who did not eat fish at all. That apart, fish helps in improving motor and communication skills. However, there are some fish, which can contain mercury, which is harmful for your baby and you.

Always follow an FDA recommended instruction to eat fish.

Last but not the least; get yourself a good sleep of at least 8 hours. For a healthy pregnancy and your safety, you must ensure to follow these essential instructions.

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Days of clinical research empower scientists to discover novel methods using stem cells to develop more humanlike tiny kidneys. This is something, which is not as new to us as we had enough of such research-based organ development for kidney impairments earlier as well.

More the number of new methods to investigate etiologies of kidney disorders are developed, more prospective and fruitful results we can expect.

Why Stem-Cell Based Research Is So Promising?

As far as tissue engineering is concerned, they turn out to be a promising therapeutic approach to facilitate kidney replacement and regeneration therapies. So, developing the method for any kidney tissues depends largely on comprehensive insights into kidney formations, which can contribute to mimic the process in cell culture in the lab.

With a better data through stem cell research, it is likely to receive more precise and accurate information about the kidneys, enabling researchers to develop a better functional kidney.

This is another feat of stem cells, which raises a prospective result for us to avoid renal failure and its debilitating consequences. Kidney disorder or failure is a growing concern for American adults as it affects about 30 million citizens among them or about 15% of the total population. The number of affected patients is higher than those patients suffering from breast cancer and prostate cancer combined.

Since, the mini kidney regeneration is a hope for us to replace damaged kidney, there is another study, proving to be a prospective method to repair damaged kidneys too.

Kidney Repair Requisite

Our kidneys are a pair of important organs that helps discharge waste products from the bodies, while filtering and cleaning our blood to detoxify it of all the waste products. Unlike skin, kidneys have very little capacity to heal by themselves to repair its scar or damage. On failure to exert this key function, the damaged kidneys in the patients worsen their conditions, pushing them to suffer from end stage kidney disease. The condition leaves the patients with no options, except dialysis and kidney transplant.

But, a novel therapy is a possibility that may help to repair damaged kidneys and help patients avoid these costly treatment options like dialysis and organ transplant.

Hope for the Kidney Patients

Kidneys have some cells with the characterization of a regenerative capacity. This fact has been brought to the light by scientists in Italy. These cells with transcription factors CD133 are a type of molecules, which have the capacity to sustain renal injuries and regenerate various kidney cells.

Scientists at the University of Torino wanted to work on these cells and wanted to gauge how these molecules worked to further the process of tissue repair in damaged kidneys.

The Process of the Research

The scientists used a chemotherapy drug cisplatin, used for the treatment of cancers. In addition, the drug is supposed to affect the functions of kidneys too in at least one third of the patients. It was found that CD133 played a key role in helping recover damaged kidneys in the patients, while preventing the progenitor cells of kidneys from aging. This is important to help repair damaged kidneys in the future.

This is helpful for the further research of kidney disease, so that with infusions of CD133 molecules, it will be possible to help patients with damaged kidney repair one day. Although the process is effective for the treatment of last stage of kidney ailments, it is hopeful that the process can help people with an early stage of disease also and remove the complications completely.

Sources:

• https://blog.cirm.ca.gov/2018/04/12/stem-cell-study-holds-out-promise-for-kidney-disease/
• https://news.usc.edu/136567/usc-research-helps-stem-cell-experts-develop-kidney-treatments-reduce-dialysis/
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980673/

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Obesity is a growing concern for the upcoming generation, and it has been a leading health problem for people across the world for many years now. Most surprisingly, we did not have any potential therapeutics to ward off its complications, adding to our woes and dilemma.

The reasons could be a lack of transparent methodical procedures to find its etiologies as well as pathophysiologies.

As per a new study, obesity is the result of neural functions, which monitors a signal between hunger and satiety. The first time ever revelation could lead to a better evaluation of experimental therapies for obese patients, and find them better results with just the right kind of treatment.

Scientists at Cedar Sinai have reprogrammed brain neurons of patients with obesity using iPSC hypothalamic Neurons. These lab grown new neurons are promising to aid in the development of specific treatment procedures for the patients with specific symptoms by gauging the functions of brain in obese individuals.

The inclemency of obesity does not need much description to explain its characteristics towards the sufferers. If statistics are to be believed, a huge U.S population is suffering from this debilitating disease. They are more prone to suffer a cardiac attack, glucose complications, strokes and different types of cancers. That apart, the young generation is at a higher risk, and there is a growing concern for childhood obesity too, hindering the next generation from leading a better life.

How The Study Proved An Influence Of The Brain On Obesity?

It is the hypothalamus region in the brain, which controls the feeling of hunger and fullness using neurons by integrating endocrine signals. This is what the new study has concentrated, and shed light on the causes of obesity. Apart from monitoring hunger and fullness of the brain, it is linked with the regulation of the body temperature and other physiological functions.

Partly, obesity occurs due to the genetic mutations in the specific hypothalamic neurons. The metabolic procedure is also regulated by these neurons. In addition, these neurons help ease the communication process between the brain and gastrointestinal tract. When there is a malfunctioning of these neurons, it triggers a problem, making it tough for us to differentiate between the feeling of hunger and satiety. So, with no proper sense of self food need, our brain is likely to chomp too much food without any signal, resulting in overweight.

Since, it is not possible to carry the study on living patients, scientists turned to iPSC technology to assess the efficacy of the study.

Process of The Study

Scientists collected blood and skin specimens from five super obese people with a BMI of 50 or more, while seven individuals of normal weight with a BMI of 25 provided their samples too. These cells were then coaxed to produce induced pluripotent stem cells as they have the potential to develop into any cell types in the body, and finally they were manipulated to transform into hypothalamus neurons. The produced stem cells had the same genetic expressions as the donor cells.

There was a huge difference between iPSCs derived cells from the obese and normal individuals. The obese cells were found to contain numerous genetic mutations, and they did not respond in compliance with the hormones responsible for monitoring a series of functions like hunger, satiety and metabolism.

The study proved how iPSCs could be the potential tool to examine the etiology of obesity. Therefore, it is possible to influence the chemical signal between the genes and environment to influence its occurrences.

However, as of now, there is only one hurdle to create a connection among gut, liver, pancreas and other organs like human hypothalamus neurons, which is largely missing with the lab grown iPSCs. We are hopeful that studies will be successful to remove that hurdle too, and create an advanced therapeutic for obesity in the future.

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Music- it is so harmonious to your ears when it really yields a feeling of joy to your heart. The music has the power and is an advanced skill believed to spread joy throughout a lifetime. Not only does it limit its goodness to mesmerize you, it is equally beneficial for your kids too. Multiple studies have already advocated for the encouragement of music among kids as they improve cognition, memory, expressiveness, and self-confidence. If you worry, you cannot encourage your baby for the music education; you may be surprised to know that even the fetus in the womb reacts to the sounds of music and move in the uterus. Is this enough convincing to inspire your babies for music learning? Let us see.

It is usual to see your baby tapping their feet to the tunes of radio commercials or heavy music being aired on the TV. But, do you think this is the right parameter to judge their liking for music?

Perhaps, this is not the correct standard to measure their attachment to the music, but music does have some interesting components, yielding good results for the development of babies.

A comprehensive study spanning over ten years by the UCLA professor Dr. James Cattarell, proved beneficial for children.

The study reported an improvement from a perspective of education, which monitored more than 2,000 students and concluded that students involved in music did better results in academic examinations than those without musical involvement.

Every child loves music and it is universal, no matter how old are they. Even a child as young as six months old can benefit from music with a regular exposure to it. Music has the ability to build their math concepts and not to mention- their fine motor skills.

So, how early should you start to encourage your child to learn music and what benefits do they provide for your baby?

Music provides you the best opportunity to bond with your baby. You can initiate the process of music learning as early as six months. With different types of musical instruments being introduced to them, they can explore their fingers and toes and learn the importance of their movements.

Enhance the Listening Skill

Being a parent, it is crucial that you listen to music and expand the preference of music. This will allow you to discover the preference of your kid too. There is no musical bias in children, and they love music only because they love it without any influences from the external media. If you want to instill a taste of music in your kids, it is important you listen to music with your kids. Play a CD or record collections.

Sing It

It is so cute and lovable when your little one sings. Regardless of it being without any perfect pitch and rhythm, they sound just super fine and melodious to your ears. They sing anytime they like. But, parents do not hold onto their musical skills all through their lives and feel uneasy to sing any song.  Keep it in mind that children just do not care how you sing; they just want your participation. So, join them and enjoy the fun singing with your baby. Singing together eases the bonding and makes every day activity enjoyable.

Make a Jig

It is interesting to dance to music. When you encourage your kid to dance to music, it helps them burn off calories and sharpen their brains. Get into action with your kid. Always remember that it is a better way to keep your baby physically fit all through the year.

The music is dynamic and meant to be fun only. So, unleash the best of music to your baby and let her enjoy its essence.

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A remarkable achievement in the world of regenerative medicine, especially for victims of severe burns and suffering from skin conditions, came forward when scientists reported that they were able to successfully engraft modified stem cells in order to grow skin over a 7 year old boy. Suffering from genetic disease known as Junctional Epidermolysis Bullosa (JEB), the 7 year old boy became gravely ill and was taken to Children’s Hospital of Ruhr-University in Germany in 2015. The condition was such that made his skin extremely delicate wherein a slight abrasion such a stroking or rubbing that made the skin to erupt.

When the boy was brought to the hospital, the team of doctors noticed that he was suffering from “complete epidural loss” over 60% of the body surface. In order to manage the pain, the boy was put on morphine and was fighting off a systemic staph infection alongside. Having tried their very best, be it antibiotics, multiple dressings changes as well as grafted skin donated by the boy’s father, his parents were told to be prepared for the worst.

We had a lot of problems in the first days keeping this kid alive,

Tobias Hirsch, one of the treating physicians, recalled in a conference call with reporters this week.

Having no other ways to turn to Hirsch and his colleague Tobias Rothoeft started looking to medical literature in order to find a way out. They came across an article by Michele De Luca, of the Center for Regenerative Medicine University of Modena and Reggio Emilia in Italy, that described a procedure still in its experimental stages that would theoretically be able to produce skin cells.

Post contacting the author, De Luca flew to Germany and using the methodology detailed in her research article, harvested cells from a four-square-centimeter patch of skin on an unaffected part of the boy’s body. Having brought the harvested cells back to his lab, he then went on to genetically modify them in such a manner that it would no longer possess the gene that was mutated and caused the condition that grew the cells into patches of genetically modified epidermis. The research reported that, “the human epidermis is sustained by a limited number of long-lived stem cells which are able to extensively self-renew.

Undergoing three surgeries over eight months, the skin that was genetically modified under laboratory conditions was then grafted over 80% of the boy’s body. Whilst the procedure was not approved, it was permitted under “compassionate use”, which gives exemption under conditions where there are no further treatments or therapy available.

During the waiting period, the 7 year old boy’s recuperation was spectacular.

The epidermis looks basically normal. There is no big difference

De Luca said. He said he expects the skin to last “basically the life of the patient.

Whilst there are many challenges that De Luca will face to be able to bring this procedure up for medical approval, he says,

No matter how you prepare, it’s a bad situation. I will continue to study the procedure in two clinical trials that involve genetic diseases.”

On the other hand Rothoeft said:

The kid is now back to school and plays soccer and spends other days with the children.”

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There are always some jitters when it comes to the Big Day of delivery. With every passing day the mother becomes more and more conscious and the nerves start to act outlandishly at times.

The idea is to remain calm and know what to do under pressure. Check out this exclusive list of activities that you need to ensure in order to prepare for labour and delivery.

Take Some Antenatal Classes

When you take some of these classes conducted by the maternity hospitals, your nerve tends to settle down as you will find yourself amongst a group of women who are at the same stage as you are.

These classes will also help you to learn some important breathing techniques and will equip you with the skills of managing pain. They also will let you know what to expect after the first few minutes of your child’s birth and how to cope with the stress. These classes are extremely beneficial for the first time moms. If possible, take your birth partner along with you in these classes.

Massage Your Perineum

Massaging your perineum with some lubricating Vitamin E oil is a perfect way to ensure that your cervix is all relaxed and the baby can come out comfortably. The doctors normally suggest the would-be mothers to massage their perineum on a regular basis 2 to 3 weeks before the estimated delivery date.

However, remember to wash and dry your hands before you do that because the chances of bacterial infestations are pretty high and you should do well to avoid that.

Prepare For the Unexpected

Do not get fixed on the idea of a picture perfect delivery because that will eventually put additional strain on you. You need to remain strong and prepare for the unexpected because the membrane might rupture even before the due date.

In cases of water breakage you must be taken to a secured medical facility. That is why it is always wise to get admitted at least 3 to 4 days before the expected delivery date.

Distract Yourself to Deal with the Mood Swings

As the big day approaches your body will undergo tremendous hormonal changes. This will impact your overall mood and mental stability. The more you think about it, the more stressed out you will feel.

That is why it is also important that you distract yourself a bit. Try and have a small outing with your friends and family or watch some movies which might cheer you up.

Do the Kegel Exercises

Kegel exercises often strengthen your pelvic muscles aiding them to take the stress of the delivery. This will ensure the proper flow of blood throughout your body and will make it ready for the delivery.

However, do not try such exercises on your own. Consult your physician or caregiver before starting with the workout routine.

Apart from all the above mentioned things, you should always stay in touch with your gynaecologist and inform him/her if you feel that there is something out-of-order.

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If you’ve not had much time to delve into the subject of cord blood banking and if you can opt for it in case of a natural birth, then here’s your chance.

The blood that remains in your baby’s umbilical cord, post birth is known as the cord blood. Earlier, the umbilical cord was treated as a medical waste and was usually discarded. However, with regenerative medicine now on the rise, many parents and families are choosing to either store their babies cord blood unit privately, or donating the same to a public cord blood bank.

So what actually happens during the process?

The process of collection of the cord blood from the baby is quite simple. The blood from the baby’s umbilical cord blood is extracted through a needle from the umbilical vein on the part of the cord that is attached to the placenta. The blood is then collected into a special blood bag that is part of your collection kit and then sent to the laboratory for processing within a timeframe of 72 hours. The sample, at the laboratory is then tested and frozen.

The observation that comes to mind is that the entire process has to work like clock-work.

Hence, can one actually opt for this service if they choose to go for a natural birth is something that you may be wondering about? What if you get your labour pains start earlier than the date that you’ve provided to your private cord blood bank? What if you are unable to get in touch with your cord blood banking service provider during this time? There are a lot of ‘what ifs’!

So the question is if one can choose to opt for cord blood banking during a natural birth can be easily answered.

Most birth plans, can accommodate cord blood banking as a collection of the sample takes place post the baby’s birth. The collection process in itself is less than a five minute. So basically, in the turmoil and joy of delivering your bundle of joy into this world, you probably won’t even notice, when the clamping has been done and the sample has already been collected.

However, one must ensure that your healthcare provider has been informed beforehand that you wish to opt for cord blood banking. Also, in case of private cord blood banking, you must inform the private storage bank that you intend to opt for a natural birth and they may have to send out their trained phlebotomist to collect the sample when you get your labour pains, closer to your delivery date. Have the number of the Executive you’ve dealt with through the enrolment process saved on your partner and your mobile phones. Also, if the private cord blood bank has a Hotline or a Toll-free number, it is a good idea to have such numbers saved on your mobile phone too.

Remember to carry your collection kit to the birthing center so that if by any chance the baby arrives early and the phlebotomist is unable to reach it in time, your healthcare provider will be able to carry out the sample collection. Always keep in mind that storing your baby’s cord blood sample is a once in a lifetime opportunity.

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Life is truly uncertain with its bout of ailments and untreatable diseases. This is why scientists and doctors are always in an attempt to come up with revolutionary cures and regenerative cures. And all across the globe there are miracle stories being circulated about the advanced stem cell and gene therapy and others that have cured chronic ailments. One such story is about a South African boy and his ailment. It’s Gene Therapy that has brought him back to life and made him turn a new leaf.

Born in South Africa, Ayaan Isaacs has always come across as a healthy boy. However, soon after he was born, the boy had been diagnosed with a chronic liver infection. Though he had survived the ailment, weeks later the doctors discovered that Ayaan also has an ailment that was far more dangerous than just a bad liver. It’s a rather rare ailment that left his immune system from functioning badly, to not functioning at all.

This boy got diagnosed with SCID that stands for X-linked severe combined immunodeficiency. This ailment is commonly referred as a “bubble baby” ailment. Patients suffering from this ailment are prone to infection and are required to live in an absolute germ-free environment. It has been estimated that the SCID patients can walk back to complete cure when subjected to a complete blood stem cell transplant. But for this having a genetically matched donor is essential. However, Ayaan didn’t receive any matched donor. Hence, the outcome wasn’t a positive one.

The little boy’s parents in a desperate attempt to cure Ayaan had said yes to an alternative treatment. This was a clinical trial that was taking place in the St. Jude’s Children’s Research hospital located in Memphis, Tennessee. This trial was aimed to head SCID patients with a stem cell gene therapy that attributes the patients with a completely new immune system. This therapy is all about taking the blood-forming stem cells of the patient and then treating the mutation which leads to SCID. The cured blood stem cells are usually transplanted back to the patient. It is here that a new and healthy immune system gets build.

Thankfully, Ayaan was successful in enrolling on this mentioned clinical trial. Apparently, he happened to be the very first child in the entire African continent to have access to an advanced gene therapy. His journey towards fighting with the bubble boy ailment was talked about all across South Africa. The gene therapy that Ayaan was treated to helped him revive back to life. It is essential to understand that the therapy is an experimental one. Hence, at times complications might come up. However, one must always walk ahead with courage and make the most of the treatment.

Ayaan was also featured in many videos narrating his story. It gave hope and courage to millions, who are fighting similar debilitating life threatening ailments. And considering the fact that one boy went ahead with a regenerative treatment is ample courage to many who are ailing from SCID.

Today, akin to SKID there are several diseases that are not heard of. Often doctors remain unsure as to how to go about treating the ailment as there’s always a first time to a chronic ailment. However, today stem cell gene therapy and cord blood stem cell treatment has been helping patients to combat serious ailments.

Furthermore, what gains importance through such stories is that, parents and families should count in for cord blood stem cell banking without a doubt. Whether you’re a donor or a receiver, the fact that your cord blood can cure you and others, ensures the miracle that life is.

The post Stories of Hope: The Story of a South African Bubble Boy and a Gene Therapy that Gave Him His Life Back appeared first on Stem Cell Banking Guide and Pregnancy Tips For New Parents.

Human ailments are always on the rise. And so are its treatments! Doctors and medical experts are constantly experimenting with new treatment modalities to be able to cure chronic ailments. One such medium is cord blood stem cell transplant. This has gained prominence in the recent times, owing to the success stories about patients who had strongly combat ailments through courage and advanced cord blood stem cell therapy. This is the reason why parents-to-be and families are opting in to save cord blood of their children. As even the sibling’s cord blood can be used to treat another child.

About Cord Blood Stem Cell Properties

Simply put, cord blood is one important element that is sourced from the blood which gets gathered from the placenta and the umbilical cord, at the time of the child’s birth. Things were not so advanced in the yester years, Today families and parents have the scope of cord blood banking, freezing as well as preserving their children’s cord blood stem cell tissues. This is done so that they can save their children from any chronic ailments in the days to come.

Umbilical cord blood comprises of beneficial stem cells. It is essential to know that such cells are not the same as the embryonic cells that few people consider objectionable. However, the stem cells that are sourced from cord blood are called adult stem cells, which can be sourced from the body post development. These cells are known to rejuvenate the dying cells and also replenish the damaged tissues as well.

Cord blood stem cells sourced from a child’s cord blood can simply replace or repair a damaged tissue that took place at the time of injury. This can take place at the time of malignant disorders in terms of dangerous cancers and also hematologic disorders, for instance the bone marrow transplants. Cord blood stem cells can also regenerate the immune system and also the blood flow.

The Aspect of Allogenic and Autologous Matches

Selecting a private cord blood bank to store the cord blood stem cells of a child, means that the concerned family doesn’t need to look out for any external donor in times of need! Whether it’s a family member or a sibling, the cord blood stem cell of one child that has been saved will work. However, here there are two principal matches that need to be considered i.e. the allogenic and the autologous matches.

Simply put, an autologous match takes place when one child resorts to make use of cord blood that has been saved at the time of their own birth back in time. This surely is going to be a 100% match. There are also situations when this same blood can be utilized for a sibling. In that case, it’s known as allogenic match.

Storing an Infant’s Cord Blood Stem Cells Leads to a Medical Security  Measure

We are genetically associated with our own brothers and sisters. Simply because we inherit one half of our DNA from our mother and the other half from our parents! And by going in for this logic it’s our siblings that have the same DNA as our parents. Hence, in times of need we will have the advantage of using our sibling’s cord blood stem cell tissue that has been saved or banked at a private bank. This match makes the cord blood stem cell transplant simple and easy.

Till date cord blood stem cell transplant have been known to cure as much as 80 ailments. Owing to its unique capacity the cord blood stem cell usages are many. Today, doctors and other medical experts are constantly researching on this subject so as to come up with cures for medical conditions that still are said to possess no treatments.

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It is normal when babies hiccup in the mother’s womb. It may, at times, alarm the pregnant mums, but there’s nothing really to worry about. So, as a mum-to-be, you may be wondering how your little one can hiccup when he or she is inside of you. You surely know that they are not breathing yet! But that’s where you are wrong. Breathing has nothing to do with your baby’s hiccup. If there are unexpected tightening of the diaphragm possibly as a result of itchiness or stimulation of the muscle, the baby may have a hiccup.

Once the baby is born and if you are worried about the constant hiccups then, Lynnette Mazur, a professor of paediatrics at the University of Texas Health Science Center in Houston says,

It’s a nuisance to parents, but not so much to the baby. Unless the hiccups interfere with daily activities like sleeping or eating, there’s no need to see a healthcare provider.

Gastroesophageal reflux disease is a probable cause of frequent hiccups if your baby is suffering from it. If the baby has a tendency to spit up or coughs and has a cranky disposition, then, Mazur advises that you should definitely mention that to your pediatrician. Additionally, if you observe that your baby’s hiccups are out of control, and are occurring pretty regularly, especially post-age one, then you should again consult the paediatrician as it may be an indication of a more serious medical disorder.

Karen Fratantoni, MD, MPH, a pediatrician at Children’s National Health System observes that,

Generally, if it seems the baby or newborn hiccups are related to overfeeding, belly distention or reflux. You can help alleviate hiccups by feeding baby smaller amounts more often, and remember to burp baby frequently.

Whilst in most cases, baby hiccups are harmless; here are some tips that you can follow to get rid of them.

• If the baby is being breastfed, try and burp the baby when you are in the process of switching from one breast to the other. You may be aware of the fact that babies have tendency to consume their surrounding air. Have the baby latch higher to the breast, ensuring that your baby’s lips are tightly sealed around the areola of your breast, not just the nipple.
• “Completing the feeding while he is relaxed can actually end the hiccupping,”[3] is what Forgenie recommends. Stop and burp the baby halfway, if you are bottle-feeding the baby. The bottle should be positioned in such a manner so that it isn’t any air near the bottle teat. The air can form at the bottom of the bottle instead.

There are also other theories by which you can help stop your baby’s hiccups. However, Mazur thinks. There’s really not much you can do, and they’ll go away soon.

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Our cord blood stem cells have immense promise and use! It carries astonishing medical potential. This can be used to treat diseases and also be stored for many years. The stem cells contained in the placenta and umbilical cord blood cells help in medical treatment as well. From scientific research to genetic testing, the uses are many. However, there are situations when there’s a high-risk pregnancy resulting from a hereditary condition. Here, women can count on cord blood from another donor or even their siblings, so that the delivery takes place in a secure manner. This can keep both the mother and child safe from any health related ailments.

What Results in a High Risk Pregnancies?

Simply put, a high risk pregnancy can be defined as one that poses serious threat to the baby, mother or both. There can be several health hazards and ailments that result in this. The fact that whether the infant to be born also has a similar ailment depends on various factors. It could range from anything where both the child’s parents carry genes having an ailment. Simultaneously, there could also be a trigger owing to environmental factors as well.

Majority of the high-risk pregnancies are owing to hereditary conditions, which get passed on to the child very easily. Some of the prominent ailments are all follows:

Cystic Fibrosis At The Time Of Pregnancy

A woman having this ailment might develop breathing complexities during her pregnancy period. This ailment also maximizes the chance of gestational diabetes in the body. This needs to be addressed right at the onset of the pregnancy or even before that.

Gestational Diabetes

This ailment takes place only when a woman is pregnant. There are some malfunctions in the blood sugar management that results in an increased amount of high blood sugar count. This doesn’t just affect the pregnancy, but also the overall condition of the health.

Hypertension

Overruled and often overlooked as something unimportant, hypertension can result in major health ailments. When pregnant, if a woman records high blood pressure, then this might result in kidney damage as well as other health ailments as well. The expecting child might also have low birth weight and there can be a chance of premature delivery as well.

Thyroid Dysfunction

Hypothyroidism or hyperthyroidism might lead to an excess of thyroid ailments. The thyroid hormone which is present in the mother’s blood stream might affect the child and the overall pregnancy as well. This also maximizes the chances of miscarriage. There can also be an early delivery. Few other bodily complications occurring due to thyroid dysfunction in a pregnant woman can be congestive heart failure, anemia, high blood pressure and many more. And this in totality might simply affect a child’s brain growth and development.

RH Factor at the Time of Pregnancy

There has been an instance where the baby is Rh positive and the mother is Rh negative. This results in the generation of anti-bodies which goes and acts against the blood of her baby. The pregnancy at the start isn’t much of a problem. However, going forward there can scopes of miscarriage. Also the baby born might have a chance to develop anemia.

There is a list of few ailments that results in high-risk pregnancies in woman. There are several other reasons as well. For instance, you can also have cervical incompetence which might lead to premature delivery. This condition has a chance to affect female children even more.

This is where patients often turn to cord blood stem cells for probable treatments to existing physical conditions, prior to pregnancy. Stem cells that are sourced from cord blood provide a wide scope to heal these underlying ailments and other critical medical issues. Furthermore, cord blood is also used for genetic testing as well. So once the health problems are cured using cord blood stem cells, pregnancy risks can be alleviated. Both the mother and the child can be free from all kinds of danger.

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A new record was achieved in the U.S in the year 2017, when approximately 35,000 organ transplants were performed through organ donations. However, the hard truth is, in spite of such large numbers of organ donations, demands far outstrips supply. Nearly 126,000 patients are on U.S. waiting lists for various organs, including more than 103,000 people seeking kidneys, 14,000 who need livers, close to 1,400 potential lung transplant recipients and nearly 4,000 are waiting for donor hearts.

Thus, the premise for researchers to work on a solution that can help mitigate this critical issue. For a substantial number of years teams of researchers have been trying to formulate a solution, wherein a patient’s own stem cells may be used to design and manufacture or even grown an ailing organ, for example, the heart, liver, kidney, as a replacement. This would also solve the problem of organ rejection which exists if the patient is given a donor organ during transplant.

Dr. Stephen F. Badylak, director of the Center for Pre-Clinical Tissue Engineering at the University of Pittsburgh’s McGowan Institute for Regenerative Medicine, explains in an email, “Success by this method means that the recipients would no longer be relegated to immunosuppressant therapy and would not have to wait for a matched donor organ.”

Whilst many teams around the globe have put in intensive research in finding a solution for this, the encouraging results have come from a process known as decellularisation. During the animal testing phase, this methodology enables the cells to be ripped away from the donor organ which in turn leaves a tissue scaffold. The process is such that the replacement organ can be regrown using stem cells within this scaffold.

As per the story showcased in the Wall Street Journal, Dr. Harald Ott and colleagues at Massachusetts General Hospital’s Center for Regenerative Medicine, has been working on this on a much smaller scale. Under laboratory conditions, there is a special pump to which the donor organs have been attached. This pump helps to wash away the original cells in the ailing organ and thus creates a structure wherein stem cells can be used to replace the organ. Post building the new organ, the same is then hooked to a bioreactor which creates stimulation to the organ by a pumping mechanism. The organ then expands and contracts representing as if it was grown under natural conditions within the body.

• Could Stem Cells Eventually End the Transplant Organ Shortage? – by Patrick J. Kiger Jan 24, 2018
• Could Stem Cells Eventually End the Transplant Organ Shortage? – by Patrick J. Kiger Jan 24, 2018

Subsequently in 2016, Ott’s team have had tremendous success in washing away cells from a donor heart, creating tissue scaffolds and eventually filling them with heart tissue grown from stem cells. In 2017, the team published their successful research in detail where they were able to create a small intestine from stem cells that may well help those patients suffering from Crohn’s disease.

Dr. Doris Taylor, director of regenerative medicine research and the Center for Cell and Organ Biotechnology at Texas Heart Institute in Houston, says,

Stem cell technology and new methodologies for existing organ preservation have advanced, both of which have fed in to building organs from stem cells and will ultimately shorten our path to success.

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Based on the research and clinical applications on the embryonic cells, it is measured that the adult stem cells are advancing in various ways. Though adult stem cells are considered as the red headed stepchild and embryonic stem cells are the media darling for ages, the press coverage has focused in various stages to showcase the advances in both the cases of this discrepancy.

Believe it or not, the bottom line of both adult stem cells and embryonic stem were being used in the early clinical and research-based works to simply heal the diseases based out of the cartilage, multiple sclerosis, bones, heart issues/attacks and even diabetes.

There has always been an emotional and notable debate based out of the topic embryonic stem cell and adult stem cells which continues with the testing today. An extensive and elaborative review on this project has made dozens of experts to offer their potential reviews based on it.  Apart from these regular efforts on transplants, adult stem cells have simply become standard lifesaving therapies for thousands of individuals who are suffering from Leukaemia, lymphoma and other various heart affected diseases. An embryonic stem may someday be used for massive diseases like Parkinson’s or diabetics, but these days adult stem cell has taken over the market on an initial and advanced level.

This may arise one question that how does embryonic stem cells and adult stem cells differ?

The answer is although very much contradictory but it still persists a strong ground to prove the worthiness of both the cases in much detail. We do have heard about the embryonic stem cells popularly known as ESCs. It was in the news for a decade while the concept of adult stem cells came into focus.

The adult stem cells are something that is found in everybody’s body as they are very much capable of repairing a host of tissues. In the latest research, it is quite popular that adult stem cell lines have surpassed the embryonic on various grounds.

In addition, the research also emphasizes on the fact that ASC is matured, focused, medicated, healed and dosed irrespective of the possible complications and medication out there. The ESC research is much more test tube in this response.

Few interceptions are as follows;

• Cartilage Repair: 1113 for one Adult stem cell line and 230 articles on embryonic stem cells
• Myocardial Infarction: 3451 for adult mesenchymal stem cell, and 186 for the embryonic stem cells.
• Wound healing: 330 for adult mesenchymal stem cell, 565 for adult epithelial stem cell and 114 for the embryonic stem cells.

Various details are focused by the notable American Stem Cell Therapy Association (ASCTA) white paper encircling adult stem cells vs. embryonic stem cell research.

Adult stem cells have been transplanted these days on a routine basis for decades. It started with bone marrow transplant, then transferring of stem cells. Expert doctors have recovered the fact that the bone marrow stream of a patient donor infuses to opt for treatments like leukaemia and other blood diseases. This way thousands of lives are being saved each day.

Scientists are embarrassed by the fact to discover lately but there is nothing late than never, thus, new hopes and treatments out of adult stem cells will take the medical science in a much better position in upcoming years.

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Spina bifida is a debilitating condition that affects around 1,500 to 2,000 babies in the U.S. annually. There are about 90% of children who lose their life due to Spina bifida. It leads to lower-limb paralysis in the baby born and is considered a congenital birth defect. However, an experimental stem cell therapy with surgery carried out by a research team from UC Davis Health System has given hope to patients around the world.

What is Spina Bifida?

Spina bifida is a condition wherein the spinal cord of the fetus does not close properly. It occurs even before the mother is aware is she is pregnant. Normally, the neural tube in an embryo unfurls and closes by the 28^th day of gestation. This leads to the formation of a complete brain and spinal column. However, in some the neural tube fails to close and causes a small hole in the spinal column of the fetus, that is, back. Spina bifida means cleft spine. As the fetus continues to grow, the spinal cord and nerves grow out of the baby’s back. As it is exposed to the amniotic fluid, it can lead to nerve damage and some levels of paralysis from the area downward. It can also lead to many other associated conditions such as kidney dysfunction, bladder dysfunction, brain stem malformation, and even hydrocephalus.

Most children with spina bifida die after birth due to an infection to the open spinal cord, renal failure or hydrocephalus-related seizures.

Combining Fetal Surgery with Stem Cell Treatment

The fetal surgery for spina bifida helps in improving brain development. However, it did not do much for motor function. The Management of Myelomeningocele Study has shown the effectiveness of a fetal surgery for brain development, but many children could not walk independently even after 30 months of age.

A study was conducted in an animal model by fetal surgeon Diana Farmer who was the senior author of the above landmark study. She is considered to be a pioneer in utero treatment for spina bifida. Her chief collaborator in this study was Aijun Wang, the co-director of the UC Davis Surgical Bioengineering Laboratory.

They are the first to combine fetal surgery with a placental stem cell treatment. This combination can help in reducing the effects of spina bifida. One of the most common and disabling forms of spina bifida is myelomeningocele. It leads to the emergence of the spinal cord through the back and often pulls the brain tissue into the spinal column leading to draining of the cerebrospinal fluid into the interior of the brain. The condition requires permanent shunts to drain the extra fluid.

How Does This Unique Surgery Help?

For this study, lambs with myelomeningocele were given fetal surgery to help return the exposed spinal tissue into the spinal canal. They applied the human placenta-derived mesenchymal stromal cells (PMSCs) on the site of the lesion. The PMSCs are well-known for their neuroprotective qualities. The scaffold was placed on the top to keep the hydrogel in position and the repair was surgically was closed.

There 6 lambs were given the stem cell treatment. They were able to walk with a noticeable disability within a few hours after birth. The other 6 control animals given only the hydrogel and scaffold could not even stand.

This study has given big hope in expanding the treatment in children with spinal bifida. The California Institute for Regenerative Medicine continues to fund Farmer and Wang for their study. They hope to receive further evaluation and FDA approval to begin trials in human to see if this process can help children with spina bifida live out of their wheelchairs.

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Pregnancy is one phase that every woman wants to experience even if they are intimidated by its consequences. They equally are excited to hold their baby after all the turbulence that they go through. Despite knowing that they have to confront many discomforts during this spell, they bear it with a hope that everything will turn out to be fruitful in the end. However, the attempt is always to make it as comfortable as possible. It is known that pregnancy brings many known and unknown ailments. For very few fortunate people, the entire tenure is trouble free. Even if they face no issue, headaches are the least something that bothers most pregnant women. Frequent headaches make them confused whether they should report them to a healthcare professional or not!

So, what is the exact reason due to which headache bothers pregnant women?

What Causes Headache in Pregnant Women?

Although there are no exact reasons found for headaches in pregnant woman, the flooding hormones are considered as one of the key factors behind this ailment. The increased blood volume for fetal growth and the active circulation are also considered to be crucial reasons usually in the initial spell of the first three months. Women tend to quit caffeine intake for their growing babies and this may also cause the headache as part of the withdrawal symptoms. Listed below are few other possible causes of this ailment that may take place during the course of the pregnancy:

• General fatigue
• Dehydration
• Triggered allergies
• Depression
• Insomnia
• Eye strain
• Congestion due to Sinus
• Stress
• Hunger

Do Headaches Indicate A Serious Problem or Are They Normal?

You read that right! There are conditions where a simple headache may be a symptom of a serious issue called Preeclampsia. It is a condition that affects 5 to 8 percent of pregnant women. Gestational hypertension along with too much of protein in urine, water retention and vision, kidney and liver abnormalities are the symptoms usually occurring after 20 weeks of the gestational period. If acetaminophen doesn’t relieve you from the usual migraine or other headaches, it may be a cause of concern. Try contacting a medical professional and they may probably request a complete evaluation to make sure everything is normal.

Who Are At Risk of Developing Preeclampsia?

• A woman pregnant for the first time
• Obese women
• Women who are hypertensive prior to pregnancy
• History of gestational hypertension or preeclampsia
• Women who are above 40
• Ancestral history of preeclampsia (Mothers with preeclampsia)
• Women carrying twins, triplets, quadruplets or multiples

Do I Know If I Have Preeclampsia?

Don’t worry!! Healthcare providers keep monitoring for this ailment in the prenatal check-ups and it is a common procedure for them. The blood pressure check and urine investigations performed can reveal details about the preeclampsia and if you have it during pregnancy.

Can It Be Treated Easily?

Of course, yes!! The treatment options vary depending upon the duration of your delivery. If the date of delivery is arriving close and if the baby is mature enough, your doctor may want to do a C-section and get the baby out of the womb at the earliest. If you have severe preeclampsia, your healthcare professional may try to prescribe some blood pressure medication and a probable bed rest along with strict diet changes. If your baby is not fully developed and your preeclampsia is mild, you may be advised to rest by lying on the left side to take away the fetal weight from your blood circulation system. Consumption of less salt or a salt free diet is usually prescribed. Dietary changes with increased protein intake are suggested and increased water consumption is advised on a strict note. Surprisingly, women follow it all in spite of the strict regime it calls for all for their babies to be healthy and safe for preserving stem cells!!

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Pregnancy marks a miraculous creation phase in a woman’s life! It is intense and transforms a woman both emotionally and physically. All through the first trimester to the third trimester, a pregnant woman undergoes hormonal changes and fluctuations which have an impact on her mental make-up, thought process, diet, taste palate as well as her innate response to everyday happenings. This suggests she needs to be attended with care, warmth and sensitivity. Also, any untoward comment on her body needs to be avoided as it has an adverse effect on her thinking, at times leading to depression, which ultimately isn’t healthy for the baby.

The obvious changes in the body size during pregnancy are expected! In today’s new era of free expression, sometimes people go slightly overboard in expressing their concerns or excitement in an inappropriate manner. There are times when a pregnant woman has people marvelling at her belly size, questioning her about her weight, her minute to minute health status and other embarrassing questions that can completely rob her of her internal peace.

It is essential to understand that a pregnant woman needs to be talked to in a compassionate and sensitive manner. So, asking the following questions sans any intrusion makes sense. 

• How do you feel?
• Is there any way I can be of any help?
• Do you want to talk about anything you feel is precious?

Another way you can add to her ease and relaxation is by telling her she has a fantastic glow on her face. Add in compliments like “You look so beautiful and happy” and this will activate her happy hormones more having a tranquilizing effect on her and in turn support the developing foetus.

But most often than not, people in excitement or an urgency to part their knowledge end up making a pregnant woman feeling stressed and anxious! So, here’s what not to tell her and not to do with her during those 9 months.

 Stop Telling Her She Looks so Huge, Thin or Bloated

It’s pregnancy and her size is bound to increase. But having someone constantly gaze at the belly of a pregnant woman and telling her she’s growing in size or is shrinking even in jest would make her feel unpleasant about her body. This could also be counted as a subtle act of body-shaming. Also, no two women have one size of pregnancy. So, commenting on her size would trigger her stress, thinking if her pregnancy is going right for her.

Don’t Ask If Her Pregnancy Was Natural

Naturally pregnant or through IVF treatment, a woman has complete freedom in choosing her pregnancy. Asking her this question shows an obvious discrimination towards the baby who is yet to be born, which won’t be received well by her. It might also invoke worries and anxieties that she could have read somewhere about assisted reproductive techniques. The life-form in her womb is natural, all the way.

Refrain From Touching Her Belly

There have been several instances where a pregnant woman’s belly was rubbed stating this is a good gesture and signals the birth of twins. Apart from the fact that it’s inconvenient and feels irksome, such a gesture is completely rude and violates personal boundaries that are essential to maintain.

A pregnant woman shouldn’t be treated as an object of good omen. Neither as someone who needs to be overloaded with case studies on pregnancy. Being a human being who’s chosen by the creator to give birth to another life, she needs to be handled and talked to with compassion and maturity.

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Asterias Biotherapeutics is a biotechnology company, which is dedicated to regenerative medicine. Recently they have launched a new medicine AST-OPC1 that offers embryonic stem cell based treatment for patients with spinal cord injuries. The medicine was under trail for a while and now it has been declared completely safe and highly effective for patients with spinal cord diseases.

The trial involved injecting the medicine into the affected area and patients showed improvement in their upper body function within 3 to 6 months after the therapy. Asterias Biotherapeutics conducted a press release in June, 2017, in which they have clearly stated the effectiveness of the medicine. It also recorded the detailed results after 9 months of the trial.

It was conducted on 6 patients. Each one of them received an injection of 10 million AST-OPC1 cells after 2 to 4 weeks of their injury. After 9 months, it had been noticed that all the patients showed improvements in their finger, arm, and hand movements.

Spinal cord injuries affect more than 17,000 people around the world every year. With the announcement of AST-OPC1, certainly they now have hope to restore their upper body movements. Dr. Edward Wirth, Chief Medical Officer of the trial said, “The new efficacy results show that previously reported meaningful improvements in arm, hand and finger function in the 10 million cell cohort treated with AST-OPC1 cells have been maintained and in some patients have been further enhanced even 9 months following dosing.”

Coming back to the trial, it involved patients who were suffering from severe spinal cord injuries in the neck that resulted into lack of feeling and loss of neck down upper body movement. The team at the Asterias Biotherapeutics quantified the results of the therapy by referring them as “motor levels” of improvements. These motor levels were associated with different levels of movement abilities. In the press release, the team confirmed that restoring the movement abilities, “can result in lower healthcare costs, significant improvements in quality of life, increased ability to engage in activities of daily living, and increased independence.”

After 9 months of clinical trial, the researchers at the Asterias confirmed that 50% of the patients (3 out of 10 patients) showed two motor levels of improvement. And all the 6 patients involved in the trail, showed at least one motor level of improvement. However, some of the experts might say that recovery from spinal cord injuries is possible without stem cell therapy. This is true. But no other study or therapy showed patients regaining their two motor levels of improvement within 9 months of the treatment.

Earlier data from 62 untreated patients showed that 29% patients got back two motor levels of improvement with 1 year whereas AST-OPC1 promises massive improvements within 9 months. Dr. Edward Wirth also confirmed it when he said, “We are increasingly encouraged by these continued positive results, which are remarkable compared with spontaneous recovery rates observed in a closely matched untreated patient population.”

Two motor levels is equivalent to higher quality life. For any person suffering from spinal cord injuries or upper body paralysis, achieving two motor levels is a dream and with AST-OPC1 it does not seem a distant dream at all.

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Pregnancy is a wonderful phase for any aspiring parent. Some experience a smooth journey during this time, while some may not. Chronic diseases have a great impact on pregnancy, which may turn these beautiful days into a nightmare. The context of pregnancy and chronic disease is, however, the most important factor for mother’s well-being as well as birth outcomes.

Chronic diseases are also associated with fertility for many. Many women are reportedly not able to conceive due to their chronic illness, if remain untreated. Pregnant women with epilepsy, rheumatic episode, polycystic ovarian (PCO) syndrome, vitamin B12 deficiency, and endometriosis have often experienced lower fertility. If this is the case with you, you can consider in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). Women with high risk pregnancy chances should get a proper medical care beforehand.

Now you must be wondering how to differentiate a normal pregnancy from high risk pregnancy. Well, it includes some factors like known chronic diseases, severe pulmonary hypertension, aortic and mitral valve defects, heart problems, Marfan syndrome, addictive disorders like alcohol and drugs, insulin obligatory diabetes and chronic intrauterineinfections like CMV, HSV, HIV or toxoplasmosis.

A Survey of Neonates in Pomerania (SNiP) study shows how chronic diseases have a greater impact on pregnancy by conducting the research on two groups of pregnant women. One group included healthy women and the other group consisted of chronically ill childbearing women. The study is based on the diseases that are not related to pregnancy but has a huge influence on neonatal outcome.

The SNiP study involved 5320 pregnant women. The process included face-to-face interviews, abstraction estimated from medical reports, self-applied questionnaires, and assessment of sociodemographic and health status of these women. The health status of these childbearing women also included chronic diseases. After collating all the data, the researchers had done a comprehensive pre- and perinatal variable assessment.

At the end of the SNiP study, it was found that one in fine women was suffering from one chronic disease or the other. The team also detected higher prevalence rates in them. The other results were summarized below:

• Prenatal complications were noticed to be more frequent in the healthy women compared to the group of chronically ill women.
• Pregnant women with chronic illness tend to deliver in C-section more than healthy women.
• One in ten pregnant women with at least one chronic illness gave birth to a premature child; however, only one in every thirteen woman in the healthy group gave birth to a premature baby.

Not only during pregnancy, chronic diseases have a long lasting effect even after birth. It’s the reason that pregnant women with chronic diseases often suffer from anxiety. Some women even decided not to conceive at all in their lives. Earlier, women suffering from multiple sclerosis, diabetes mellitus, or epilepsy were advised against pregnancy. But with the help of advanced medical process and proper planning, many women with chronic illness can experience a problem-free pregnancy.

It’s always advisable for pregnant women to consult a doctor and do a thorough test no matter if they are suffering from a chronic disease or not, because some chronic diseases can remain unknown as well. Have a safe and healthy pregnancy!

Sources:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943445/

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Stem cell therapies have been applied to treat many serious diseases successfully. One of these diseases is hypoxic-ischemic encephalopathy. Hypoxic-ischemic encephalopahy is mainly caused by oxygen deprivation, which leads to brain damage in children. This disease is often associated with several motor impairment and cognitive and developmental disruption during the development period of a child. However a Duke University Medical Center study had shown that stem cell therapy could be beneficial for children with hypoxic-ischemic encephalopathy.

The Duke University research was a pilot study to determine if umbilical cord blood stem cells could improve the condition of the infant, born with symptoms of brain damage. The process must be conducted within the first 14 days after the baby is born. The cord blood was collected from the baby’s own umbilical cord. The primary objective of the research was to see if stem cells could provide a concrete treatment to this condition. Secondly, the scientists would also want to see if the infusion resulted in neurodevelopmental benefits.

The study was launched with 52 children with signs of brain damage in January 2008. It took 9 years to complete the phase 1 of the study. Let’s dig deeper into the research.

The infants, who were enrolled in the study, were in their first 14 postnatal days. And all of them had diagnosed with moderate to severe hypoxic-ischemic encephalopathy. More importantly, all of them have their own umbilical cord blood stored during birth. Infants, who met all these criteria, received four infusions of their own umbilical cord blood stem cells. The dose was determined by the quantity of cord blood, available for the babies. However, the dose for each infusion was 5x10e7 cells/kg. The babies gone through follow up checkups after 4 to 6 and 9 to 12 months. Their MRIs showed significant development.

Another study on the similar subject was published in PubMed – NCBI. This study was also based on autologous umbilical cord blood stem cells to treat hypoxic-ischemic encephalopathy. Children with severe to moderate hypoxic-ischemic encephalopathy were enrolled for this research. All of them had received on autologous umbilical cord blood stem cells. They were given 4 doses of infusion. The team monitored cell infusion characteristics, UCB collection, and pre and post infusion differences. They also compared the hospital outcomes with children, who did not have available stem cells.

After 4 doses of 4.3 mL infusions, the children were examined in order to monitor vital signs. One of the main signs, oxygen deprivation was noticed to be the same pre and post infusion in the first 48 hours. However, the outcome showed significant improvements with a score of >85 later.

So, it’s shown that critical diseases like hypoxic-ischemic encephalopathy can be treated with umbilical cord blood stem cells. However, there are a certain conditions to be fit for the therapy. First of all, your child must have stem cells available for the infusion. So, as a parent, you must consider cord blood banking before your child is born. We sincerely wish you have a healthy pregnancy and a healthy baby. But if something goes wrong, you will always be prepared to tackle the hurdle.

Sources:
http://www.cerebralpalsy.org/about-cerebral-palsy/cause/hypoxic-ischemic-encephalopathy
https://clinicaltrials.gov/ct2/show/study/NCT00593242
https://www.ncbi.nlm.nih.gov/pubmed/24388332?dopt=Abstract

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The special bond between a mother and a child needs no introduction as it has always mesmerized the human race from ages with its incredible elements. Especially when the child is a baby, without having learnt verbal communication or when the baby is a neonate without even signs and gestures; mothers still understand their babies’ needs and Mother Nature has imbibed that inherent communication in both of them.

An infant child may have various requirements such as hunger, sleep, irritability due to wet nappies, colic pains, sense of security, airy stomach and so on. Since they do not learn how to emote their requirements by this age, it becomes essential to make an extra effort for the mothers to decipher them. Especially in the first four weeks of an infant’s life, it is all the more chaotic as it is the beginning of a communication in a long lasting relationship. New mothers and fathers may worry when the baby cries not knowing the concrete reason behind. However, it is important to understand that crying is the babies’ only means of communication and they cry for good and bad. Although it seems ridiculous, infants cry even if it is not a worrisome situation.

Medical professionals in fact consider crying as a neurological phase that the babies go through. The baby’s crying period at the very peak is generally between 4 to 8 weeks and it gradually lessens by the end of the year, that is, around 12 weeks. Till that time, it is no less than a feat for a new mother to understand the types of crying and the tips to pacify the child according to his/her requirements. Isn’t it surprising to know that babies cry to attract parent’s attention? They expect responsiveness from the mother and can we stop ourselves from responding when the tiny souls demand attention? Well it is hard to ignore and does not make sense!

The first impression a parent gets when the baby cries is of hunger. But it may not be necessarily that. Initially, the caregiver can feed the baby, complete the burping task, change the diaper, put her to sleep, take her into the lap, etc. on a trial and error basis. It should be one amongst these reasons. If the baby pacifies, you need to be appreciated for decoding it right. If not, try and attempt to do the following things.

Decipher The Tears

• Sing a lullaby song as babies do not sleep on their own even if they feel sleepy. Some babies want to be put to sleep. And we have to follow their order for the kind of adorable creatures they are.
• They may be comforted with a rocking action in the cradle or on a rocking chair or in the arms of the parent. This probably makes them feel that they are being attended.
• A good warm bath may put the baby at ease if he is irritated. Many babies enjoy a bath while few of them feel scared. If so, try another trick!
• Many babies instantly stop crying on offering a pacifier.
• Take the baby out for a walk. They explore the world more than what we think. Aid them in their exploration. If walking does not suit you, try going for drive instead.
• Try the football hold, with her body on your arm. They love this gesture and at times this magically works.

If any of these tricks have worked, congratulations!! If the baby continues to cry, it does not mean that you failed as a parent. Try being more and more creative in approaching the baby while offering comfort. One or the other works for sure!

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Not all diseases are genetic. But what about the ones that may pass to your children? Some serious illnesses like sickle cell anemia, cystic fibrosis, Marfan syndrome, Huntington’s disease are genetic. What are the chances that your child may inherit the diseases from you or any of your family members? Many future parents are concerned about genetic diseases before they start family planning. Some time they are aware of the risk but sometimes they don’t have enough information about their family medical history. What should you do in either case? Read on.

First try to gather enough knowledge about all the diseases that run through your family. Secondly, educate yourself about how the diseases pass through your next generation. There are mainly five factors that are responsible for genetic disorders.

Autosomal Dominant Inheritance

In diseases like Marfan syndrome and Huntington’s disease, only one parent is responsible for the generic disorder. Any one of the parent has the mutated gene in any one of the first 22 pairs of chromosomes. In such cases, there is 50% chance that the child will be affected by the genetic disease.

Autosomal Recessive Inheritance

Two of the most common examples of Autosomal recessive inheritance are Cystic fibrosis and sickle cell anemia. In this case, both the parents are responsible for passing the genetic disorder to the child, unlike autosomal dominant inheritance. In these diseases, one mutated gene from each parent pass to the child.

X-linked Dominant Inheritance

In this case, the gene mutation is found on the X chromosome, however, there are differences how female and males pass the genetic issues down their children. A male with the X-linked dominant disorder passes the disease to his daughter. On the other hand, a female with the X-linked dominant disorder poses a 50% chance of passing the disorder to all of her children, irrespective of male or female. In this case, children often tend to suffer from cognitive impairment and learning disabilities. Male children with fragile X syndrome are greater in number than female.

X-linked Recessive Inheritance

Disorders like Duchenne Muscular Dystrophy, colorblindness, hemophilia are caused by X-linked recessive disorders. The pattern of X-linked recessive inheritance is similar to X-linked dominant inheritance; however, in this case, daughters are more likely to be the carriers than be affected by the disorder.

Y-linked Inheritance

Y-linked inheritance affects male children only. A man with Y-linked inheritance typically passes on the disorder to his son. This disorder leads to infertility and difficulties in male reproductive organs development.

Now you must be wondering how to know if you will pass on a genetic disorder to your child? Simple. If any genetic disease runs through your family, it’s best for you to go for genetic carrier testing for you and your partner before conceiving the child. This test will let you know if any one of you is a carrier of any genetic disorder. Speak to your doctor today to know more about the test. You may also consider umbilical cord blood stem cell banking right after your child birth, which will protect you from many genetic diseases. Write to us if you want to know how umbilical stem cells can save you.

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When a baby is about to arrive in this world, you seem to be the happiest person. However, everything goes upside down for you not because you do not love your baby, but your lack of physical strength to take care of everything.

Reason?

Sleep deprivation. And because of this, you cannot have a good night’s sleep for weeks and maybe for months. If it continues to go this way, you may have some serious health issues too, coupled with irritations.

A recent poll carried out by the National Sleep Foundation accorded that 76 percent of parents are sleep deprived. This are nothing new and do not make any news for you when you have a baby. Right?

Issues Stemmed Out of Sleep Deprivation

Once your baby is born, sleep deprivation is most likely to go off within a short period of time. Therefore, it crops up a wide array of problems for you. It interferes with your motherhood, prevents you from taking a full care of your baby as well as your family. Sometimes, it leads to drowsy driving, which could later turn out to be fatal for you and your baby. According to The National Highway Traffic Safety Administration, an average of 100,000 car crashes takes place every year due to the drowsy mothers, while they take their babies to the pediatricians. The risk is coupled by the new mothers’ postpartum mood problems as well.

Effects of Loss of Sleep

Sometimes, loss of sleep is something more than the tired body. It puts an impact on your cognition as well as your ability to perform important chores. While it affects your deep sleep, it hugely impacts your dream sleep as well. You must know that dream sleep is important to get a clear vision for the next day’s musings, and it helps you have a clear understanding.

At the same time, the sleep fragmentation caused due your baby throughout the whole night decreases the rate of your deep sleep. And as a result, you feel exhausted.

Make Up for The Lost Sleep

When you have a sleep deprivation, you can compensate for your lost sleep. Take time out on your weekend, and don’t take the extra loads of responsibilities to get yourself two-three hours of sleep. But, do not go beyond this, as this develops a new sleeping pattern for you, and you are less likely to feel tired at bedtime.

Take A Nap

Don’t venture to take a more responsibilities, while your baby is taking a nap. Instead, try to refresh your mental health by taking a short nap of 20-30 minutes. Many individuals may benefit from this habit. But, do not make it later than 2 p.m., as it could interfere with your bedtime.

Interchange the Responsibility Of The Night Feeding

Generally, most parents work outside the home. So, either of the parents, typically mothers take the lead to make things ready much earlier to alleviate the pressure in the morning. And hence, the round-the-clock feedings can wreak havoc on your deep sleep, and cause sleep deprivation. It is better to exchange the job role every alternate night. So, while one person does all the feeding, the other one gets full sleep. At the same, the lactating mothers can opt to compress their milk, so dads can take care of their babies.

Teach Your Baby to Fall Asleep

Once your baby is asleep, it does not mean, you should get out of your bed. By six months, most babies learn to sleep for as long as 7-8 hours. Put your baby in her bed, even if she cries for you. Help her not to rely on you, instead help her sleep on her own.

So, these are a few strategies which you can take up to alleviate your sleep deprivation and make your life post-delivery much relaxed and refreshing.

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You may have heard of GERD or gastro-esophageal reflux in adults. Have you heard of reflux in babies? Well, about half of all babies who come under 3 months of age have reflux. Let us see why babies have acid reflux in this article.

What is Baby Acid Reflux?

Baby GERD or baby acid reflux is the bout of spit-up or regurgitation of food (milk) swallowed into the stomach back into the food pipe (esophagus). At times, the food goes back into the stomach or mostly is vomited back. Babies tend to spit up after almost every feed. It happens when milk and acid are pushed back into the gullet or the mouth.

Why Do Babies Experience Acid Reflux?

Acid reflux in babies occurs as their digestive systems are immature. When food is swallowed, the esophagus automatically contracts and pushes the food down into the stomach. A valve, called the lower esophageal sphincter (LES) relaxes and lets the food pass through. The LES prevents the food and acids from going back up into the esophagus. However, in GERD, the valve does not close properly or remains open. Thus, allowing backflow of stomach acids and food into the esophagus.

In babies, the reflux occurs as the LES valve is weak and may not close properly. Secondly, babies tend to lie down most often and their esophagus is shorter than a grown adult. Thus, babies spit up or burp after every feed. This is usually not painful and quite normal in babies under 1 year of age. At times, the milk may get mixed with stomach acids and come up. This irritates the inner lining of the esophagus causing pain and restlessness in the baby.

Reflux is not bad for babies as it helps reduce the pressure in case the baby has swallowed more milk and overcome the stomach discomfort.

What Are the Signs of Baby Acid Reflux?

Generally, babies do not show any symptoms of acid reflux. They just tend to spill milk after a feed. However, when acid is mixed up with the milk regurgitated, it may cause certain symptoms. When the baby who spits up after feeding that may spoil their clothes, and even yours, yet do not seem to be affected by it, means it is a normal regurgitation. However, if it bothers the baby and leads to pain, discomfort, and cry during or after feeds. Their vomiting is more significant after feeds. A few babies may vomit more than they feed and tend to lose weight or are unable to gain weight.

At times, these symptoms may go beyond acid reflux. They may be suffering from lactose intolerance, stomach infections, or gastrointestinal disorders. A few babies also suffer from silent reflux that does not cause any visible symptoms. Such babies may cry a lot and appear to be in pain with a persistent cough. However, they may seem a little relaxed when held upright.

How to Treat Baby Acid Reflux?

Baby acid reflux is not a condition that requires treatment normally. It usually goes away on its own as the baby grows. However, if it seems bothersome to the baby, then you may try changing the brand of milk for formula fed babies, or the mom need to tweak their own diet for a breastfed baby.

Give the baby frequent small feeds, so that the stomach does not get too full. Hold the baby upright at least for half an hour after a feed to allow the milk to go down into the stomach. Allow quiet time after feeds so that the milk gets digested and does not lead to discomfort and gas.

When it comes to baby acid reflux, all you can do is help your baby get comfortable and burp it all out. If it seems bothersome and worrisome to you, speak to your baby’s pediatrician for further advice.

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Life on one hand seems all bright and beautiful. And when faced with an irreversible ailment with no visible room for recovery, then it seems like uncertainty has had a tight grip on life. Ailments like cancers of all kind, immune system and blood disorders and chronic brain and spine injuries all pose a threat to life. And in the recent times, cord blood stem cell has been the only miracle cure that has been successfully combating the list of dangerous and untreatable ailments and recording victory.

Such is the story of Evelyn Hilton, who was a brave heart to volunteer for stem cell transplant to treat her brain condition. The lady at 58 witnessed a stroke back in 2014. Going by her account, it was a weekend and she doesn’t recall graphic details about the stroke. But she confirms it was a painful one and it prohibited all the movement to the left side of her body. Struggling with this condition, Evelyn wasn’t ready to give up, as she had a list of things to achieve and she didn’t want to quit all that.

Being stuck in the hospital bed makes one vulnerable at the hands of the medical system! Not having any control on her left side, Evelyn one day decided to volunteer for what seemed to her just an experiment. In the course of it a liquid mix of stem cell got injected to her brain cells. During that time, this revolutionary treatment was experimented only on selected patients and the outcome were safe and very effective. The process did however require a hole to be drilled in her skull.

The stakes were high and the results were expected to favourable. But just the idea of drilling a hole into the skull seemed painful and challenging. In her own words, Evelyn expressed her desire to be back to normal, daily life, was so strong, that she was prepared for almost anything. All she assured herself was that the process might just help her heal back than stay in the stroke indefinitely.

Recounting her story, she says, that she reached the hospital within a span of 4 hours and received proper medication that helped to eradicate the blood clot that had taken place and averting further damage. And after she received the stem cell therapy, on the 6th month of her treatment where patients are noted to recovery, she wonders if she would get any better without that. Filled with grace and gratitude Evelyn says that in the time frame of two and half years of her stroke, she has only seen health improvements post the stem cell therapy. Though the changes have been slow, but they are consistent and that’s what helped keep a positive attitude to life.

Over the past few months, Evelyn confirms that she has recovered in a huge way on the left side of her body. This made her do away with the walking stick. She has left it and it’s been a while. She didn’t want the world to look upon her as a disabled, old body but rather as one who is continuously improving in body and mind, with every passing day.

For Evelyn stem cell transfusion has a miracle cure. She isn’t completely normal but has recovered almost 40%. She considers herself lucky to have healed to this extent. There are several such stories of hope where cord blood stem cell therapy has brought back life in people where the end was almost inevitable. This only proves stem cell therapy is the future of regenerative medicine and counting on cord blood banking has its positives.

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Do you ever think what would have happened if there had been no discovery of the various significant tools for the diagnosis of untreatable diseases? We would have never got to the bottom that underlies the key causes of a range of diseases. And in our quest to discover more pathways to identify the etiologies of the diseases, and their severities, we need disease models for a better understanding. With regard to this, stem cells have been a great tool to foster our medical researches and discoveries of various new therapies and treatments. Let’s remove the veil to uncover the role of various stem cell tools in disease prognosis, diagnosis and their treatment options.

Various Stem Cell Tools to Understand Complex Diseases

IPS Cells

First of all, we must thank Shinya Yamanaka for inventing the human induced pluripotent stem cells using reprogramming technology to turn them to behave like embryonic stem cell like state. Since, iPS cells behave like embryonic cells, it is possible for them to turn into many cell types, and finally develop into skin, nerve, heart muscle and anything.

Ever since its inception, these reprogrammed cells have proven to be a boon for the regenerative medical therapies and novel therapeutic uses. Therefore, it is easier for researchers to regenerate complete organ tissues for liver, heart, skin, and blood using their cells, and reprogram them into iPS cells. As is with iPS cells, we would have fewer concerns over immune rejections, and no more ethical concerns for embryonic cells.

In order to understand the pathophysiology of certain medical conditions including macular degeneration, Parkinson’s diseases, frontotemporal dementia, iPS cells work as a great stem cells-based tissue models. However, the scientists found that observing the affected cells in comparison with healthy individual cells, iPS cells fail to work efficiently in the culture. Rather, they focused to introduce gene editing technology in the iPS cells to better understand the disease pattern. The process of disease diagnosis has been simplified by the introduction of gene-editing tool CRISPR CAS 9. The introduction of the disease-associated mutations in the specimen of iPS cells provide a clear vision into how the disease behaves in comparison with healthy and unedited cells. They can prove to be even more useful in identifying Alzheimer’s linked mutations through the editing of a single copy of a gene, rather than both the copies.

DNA Sequencing

Another effective tool namely DNA sequencing technologies are useful to develop human biology and improve medicines. Rather than just decoding DNA, it is capable of assisting scientists and researchers to study genomic data, which offers elaborate insights into the manipulation activity of the genes. Even in the tissue modeling of DNA sequencing, we need to the take help of iPS cells. RNA sequencing experiments allow the researchers to discern the raw data to unravel the gene’s turning on/off activity. Being the photocopy of the DNA, it is their general functions to carry information embedded in the DNA. In addition to this, RNA sequencing is more apt to expose the characteristic of specific cell types and their diversities. This RNA based sequencing helps scientists identify the accuracy and efficacy of the stem cell models in comparison to single cell-based models. Hence, using this tool, it is possible for scientists to find the accuracy rate of the stem cell models based on the genetic profiles.

BOC

The Brain of Cells- it is a scorecard being developed with a single RNA sequencing derived from thousands of fetal brain cells. With inputs from RNA, this scorecard will distinguish between brain cell types and their developmental states. This would be a milestone in understanding the neuroscience and the etiologies of neurodegeneration complexes.

With most advanced stem cell-based models, we can be able to develop tools to better understand the cell fates and their states. Thus, we could develop better disease models using this information and create effective therapeutics for use in future.

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It is because of the jaws, all vertebrate mammals can consume food using various techniques like biting, chewing, and managing food. But, did you know which chemical is behind the formation of this framework of the mouth?

We would have not developed our upper and lower jaw, as well as teeth buds, palatal shelves, including some parts of the brain and bones, had there not been SATB2.

What is SATB2?

Special AT-rich Sequence-Binding Protein 2 or referred to as SATB2, is a DNA binding protein. We can find it through an expression of epithelial cells of the colon and rectum, and also in the neurons of the brain. It plays an active role in remodeling chromatin and regulating gene transcription. Its capability to bind AT-rich DNA sequences is known as a matrix attachment region or (MAR). And because of MAR, it can encode proteins in the body.

While a mutation in SATB2 is a leading cause of a range of diseases like osteoporosis, neurodevelopment disorders and impaired speech, it exposes us to colorectal cancer too.

A cancer of the colon, which is a global threat to put the patients’ life at stake worldwide. Being a metastasis, it is resistant to various cancer drugs and therapies including chemotherapy, radioactive treatments and others. Thus, patients can experience relapse risks once their cells in the tumors resurface to bother them again, and gradually drive them over the edge of death.

This new discovery has been brought into the limelight by the researchers at the LSU Health New Orleans School of Medicine and Stanley S. Scott Cancer Center. They reported it in their online publication in Nature Research’s Scientific Reports. As per their findings, SATB2 is a novel proteins, which dwells close to the colon, and becomes malignant.

Since it has metastatic characteristics, it can grow faster and spread, and also mimic other stem cells in the body to turn as cancer stem cells.

Elaborate View On The Finding

SATB2 is a protein with an inbuilt capacity of on/off signaling pathway. By using that switch, it instructs a certain cell in the cancer cells to get activated, or get deactivated. With an activation of certain signals, cancer cells can turn into cancer stem cells, and seem to perform as instructed by the signal.

Dr. Shrivastava compared healthy colorectal cells with colorectal cancer cells, and they found that healthy epithelial cells of colon tissues do not comprise activated SATB2 proteins, while it is highly activated in colorectal cancer cells.

In order to gauge the performance of SATB2, the research team developed extra copies of the same proteins in normal cells. It was revealed that these cells had evolved to differentiate and proliferate as a cancer stem cell with an enhanced growth rate.

And once the SATB2 expressions are turned off, they do not mimic the characteristics of cancer stem cells, and the growth of colon cells is also suppressed. Along with this, it fosters the prevention of cancer cells from transforming into cancer stem cells.

Dr. Shrivastava believes that it is possible to bring about a new drug or therapy, and better diagnosis process based on the finding of SATB2’s higher expression capacity in the colorectal tissues or cells. In addition to this, it could be used as a novel marker to identify the severity of colon cancer in the patients.

Now, we can be hopeful about the new finding of an agent which can prevent SATB2 from affecting stem cells in the colon tissues to cause colorectal cancers, and other forms of cancer too.

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Despite having therapeutic advances in the medical fields, we continue to receive destructive outcomes for the patients with cardiovascular diseases. Not only have cardiovascular disorders such as myocardial infarction causing congestive heart failure, become a growing concern for every individual, it emerges as one of the sole cause of deaths in Western Countries.

However, we have too many evidences from clinical trials and medical research, which prove the efficacy and potentiality of stem cell based therapies in treating cardiovascular disorders. They are capable of fostering revascularization of cardiac tissues, regenerating cardiac tissues and also reinstating the cardiac performances.

With several recent experimental studies finding success through the use of different stem cell populations, it raises promising hopes for the patients of a complete relief from the severity of the diseases, and also heavy medical bills. In recent times, there have been a huge application of skeletal myoblasts, embryonic stem cells, endothelial progenitor cells, hematopoietic stem cells and not to mention- the mesenchymal stem cells in biomedical research for the development of regenerative therapies.

That apart, another study in the recent times has showcased a positive outcome for the treatment of cardiovascular disorders using human umbilical cord-derived mesenchymal stem cells.

While human umbilical cord derived stem cells are a useful tissue for combating various adamant diseases, it has become a great potential for us to save these cells through UCB banking, giving us an equal opportunity for future use. As UCB banking provides us with opportunities to preserve these precious cells, the growth of the UCB banking is on the surge as well. Notwithstanding, it is worth discovering the efficacy and importance of UCB mesenchymal stem cells on cardiovascular research, and finding more promises for our health care.

Why UCBMSCs Are A Useful Component In The Research Of Cardiovascular Diseases
MSCs have unique properties to differentiate into a myogenic phenotype in vitro, hence it is capable of alleviating the symptoms of ischemic and nonischemic related cardiac complications. Another study suggested that bone marrow derived autologous MSCs have properties like cardiomyocyte like cells, which reinstated the cardiac functions of a rat with cryoinjury. br/>
And because of this wide array of advantages of MSCs in the heart related complications, UCBMSCs are constantly being used in the research to develop effective strategies to be used for relieving cardiovascular disorders.

In addition to this, for immune deficiency disorders and human blood related diseases, UCB cells has shown some potential properties to replace the HPCs in the clinical setting as a source for research since 1988. At the same time, these cells derived from UCB contain the properties of MSCs as well, and therefore they are effective in treating idiopathic dilated cardiomyopathy as well.

We can have a clearer insight through an investigation theory carried out on mice at the most recent time into the efficacy of UCBMSCs.

Clinical Methods
Mice with cardiac infarction, including healthy mice received UCB mononuclear cells infused with CD34- positive cells through a transplantation. They were observed for 3 weeks.

It was found that both healthy and infracted mice had received UCB cells to their liver, spleen and bone marrow. However, only the mice with cardiac issues had transplanted cells on their hearts. A reduced heart size, coupled with collagen deposits and increased capillary density were signs of their myocardial infarction.

Therefore, this result of the study showed that UCBMSCs have the potential to return to the infarcted heart with transplantation and aid in the growth of heart tissues.

More such uses of UCBMSCs can be developed like its use in cardiovascular research, and we are likely to receive many cells based strategies for tissue regenerations. And this finding will be one day effective in establishing therapeutic treatments in future.

Sources:
https://www.hindawi.com/journals/bmri/2015/975302/abs/
https://academic.oup.com/cardiovascres/article/66/1/4/463927

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Pregnancy needs care! You might sign up to work during the first few months of your pregnancy, as you don’t want to get restricted in a room, all day, whole day. You might also want to catch up with your office friends and talk about your experiences. Or simply, you could choose to work, because you love to work. But that doesn’t take away the fact that you have to maintain caution with your health!

Based on a study published by the “Obstetrics & Gynaecology”, Reuters Health, most pregnant woman who opt in for a night shift at work, usually steps into the danger zone of having a premature delivery. Day shift doesn’t pose such hazards. So, what do you when you have to work a night shift and you can’t transfer for a day shift even on request? Here are few useful tips to help you sail through this and stay free of any health hazards.

However, during pregnancy you ought to avoid yoga postures that involve the following:

• If your job requires you to keep sitting for long hours during the night, make sure you have a comfortable posture. Don’t keep sitting in one position for long as that will lead to cramps and pains. Also ensure that you don’t strain your back or that your stomach region is not over stressed whilst sitting. Carry a cushion with yourself and keep it at the back of the seat, which will add comfort to your sitting position. Also make it a point to stretch your legs at an interval of 30 minutes. If possible, take a walk sometimes in between your work.
• Health and nutrition is essential during pregnancy! When you’re working at night, your body uses more energy. So, it’s always beneficial to carry fresh fruits with you to office. So, pack in a box of nuts, almonds, your choicest fruits, glucose biscuits and juices. Snack on it whenever hungry. This will help you keep your energy level high. And chances are if you finish your work fast, you might have the chance to return early as well.
• Avoid wearing tight clothes at all cost. Your body needs to feel free and relaxed as you are working. Stick to comfortable loose clothing that will help you move around easily and breathe well too. Though you might not need it but carry an extra pair of clothing for safety.
• Let go of the need to perform extra well during your pregnancy! Once you have the baby and re-join work, you can get going with all your creative chops and management skills and prove your worth. Do the basic needful when you’re at the night shift whilst your pregnancy. Also keep your seniors informed about it, so that they don’t overload you with excess work. Also place in a request that you might leave early or do a half-time if there’s a health concern suddenly.
• When back at home don’t skip a 7-hour sleep. This is when your body will work up for all the wear and tear that happens during the night shift job. So, don’t compromise on the sleep. Set an alarm and make sure there’s nothing coming between your way and the sleep.
• Often night shifts at office mean comfort eating! So be a part of the fun but stay away from consuming non-vegetarian means brought by your fellow workers. This will result in indigestion. Resort to a healthy food habit at home and work instead. Consume raisins, almonds, green tea, lots of fresh greens, berries and other wholesome, healthy food at night.
• Keep your doctor’s number handy so that you can dial as and when there’s a need.

So, if you have a night shift to attend, these are some of the tips that will keep you healthy during your pregnancy.

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No woman can escape the sudden emotional swings and health discomforts that happen when pregnant! However, with an aim to stay fit and healthy women can do away with these sudden discomforts. Exercising is a vital part of pregnancy and it helps women feel better. Though you must rest as prescribed by the doctor, but skipping exercises just because of the mild morning sickness, which is a pregnancy spin-off is not suggested. So, if you’re on the first 6 weeks of your pregnancy, here are the best exercises you can do at home, under expert supervision, preferably.

1. Keep Walking, Keep Moving

According to gynaecologists and health experts, pregnant women need to keep walking or moving! Take a brisk walk in the corridor of the living room or the balcony or garden space. This will result in more energy, vitality, reduced back pain, a healthy body image and also returning to form quicker and better after delivery. You can start by taking morning walks and evening walks once you’ve checked with your doctor.

2. Opt in For Pilates

Pregnancy brings in two bodily challenges for women: first lower back pain and second balance issues. When you practice Pilates, you can gently build on the core muscles via a series of floor exercises. In the initial sessions you will completely concentrate on generating strength. The lessons that will follow will be challenging for your balance and strength.

However, it’s best to avert Pilates poses where you need to lie down on the back or have the twist your mid-section. It’s best never to overdo your exercises or any belly-focused posture. Else it might lead to diastasis recti, where the parallel sections of the abdominal muscles get separated.

3. Swimming Can Be Good For The Body

This is an apt pregnancy exercise to follow as the entire body is in motion here, with mild stress on the joints. Furthermore, the water in the pool supports the weight and offers you a momentary relief feeling all bloated and heavy as your belly grows with every passing day.

4. Try Pelvic Floor Strengthening

Starting the pelvic floor exercises is beneficial! So, when you switch to this exercise form you need to imagine that you are pausing the urine flow in washroom. Draw your breath and contract the pelvic muscles inwards and then upwards. Perform this at home under supervision so that you don’t stress your pelvic muscles too much.

5. Yoga Helps You Stay Fit and Happy

This is one of the best exercise forms to practice during the first 6 weeks of your pregnancy! Yoga balances your muscles, helps in generating core strength, minimizes blood pressure, ensures that your muscles are agile and nimble and teaches you breath-work that comes to help during your baby delivery. For women, yoga is also beneficial for menopause and prevents ailments such as osteoporosis, by developing bone mineral density.

However, during pregnancy you ought to avoid yoga postures that involve the following:

• Lying on the back
• Intense back-bends
• Hot yoga or Bikram yoga
• Any kind of posture where you have to place your feet atop the head, for instance headstands
• Postures where you need to twist your abdomen

6. Aerobic Classes

Today, there are several aerobic programs especially designed for pregnant women that help them to develop muscle tone, add on to their flexibility and you boost heart health. All these work hand in hand to keep the body supported as it witnesses pregnancy related changes. You can hire an instructor home as well and practice aerobics.

Following these 6 great forms of exercises on the 6th week of your pregnancy will help you ease your pregnancy discomforts and have a smooth delivery.

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Though the learning that you’re pregnant comes to you as a blessing, but the 9 months that are to follow will bring for you a set of physical challenges and emotional mood swings to deal with! A woman’s body undergoes layers of changes during the pregnancy phase. And aches and pains are a part of it. It would be misleading to say, one can completely eliminate these physical discomforts. However, by implementing certain simple ways you can certainly ease off the pregnancy aches, pains and other discomforts.

Minimize the Abdominal Pain

To ease out those difficult pains and cramps that generate from stretched abdominal ligaments and muscles, you can opt in for a warm shower. In addition to that, daily exercise that is suited for pregnant women will also strengthen and tone the abdominal muscles, making it less prone to aches and pain. However, you should in all situations avert any kind of exercise where you have to be on your back. If at all you attempt that, don’t stretch it beyond few minutes once you’ve crossed the first trimester stage, as it has the chance to minimize the blood flow to your baby in the womb.

Tackle Morning Sickness Smartly

Morning sickness is a regular after-effect of pregnancy. Especially, in the first trimester you can feel nausea during any point of the day. This might lead to mild body aches and mild headaches as well. The best way to manage this is by eating small meals, but frequently. Your diet needs to be rich in complex carbohydrates, protein and very low in fatty foods and sweets. In addition to that, drink plenty of water and consume ample amounts of vegetables and fruits.

You can even consult your doctor and gynaecologist and check if they are okay with recommending you with Vitamin B6. Also bring down your stress and anxiety levels, as hormonal fluctuations that happen during pregnancy can increase tension.

Relieve Your Breast Discomfort

Breasts tend to become sensitive during pregnancy. The way out is to wear an inner-wear that offers ample support. You can also make use of nursing pads inside the inner wear when your breasts leak.

Treat Your Backache

It’s best to keep your weight under check with regular exercise and a healthy diet. You also should stay away from taking any kind of pain relievers, until the pain is acute and a medicine is needed to heal it. There are couple of exercises that will help you minimize your backache. You can opt in for an elastic sling or a pregnancy girdle that will provide proper assistance to your abdomen. You can also wear shoe inserts that are specially designed for pregnant ladies. High heels are something that you need to avert in all possibilities.

Backache gets worst if you are standing for a prolonged period of time. So, don’t stand for long periods of time. Instead, sit straight and sleep tight on a firm mattress. If the pain increases lying down on either side placing a pillow in between your legs will offer the much-needed relief.

Also ensure that you are cautious when lifting children or any heavy loads. Opting in for a chair massage is also great. You can sit on a chair, with your back straight. You need to lean forward on the back of the chair and allow your head to rest on your crossed arm. And direct the one who’s giving you the massage, to make the massage strokes long, moving upward and outward from your lower back. Take care not to exert any pressure on the spine.

Following these simple and easy-to-implement tips you will be able to manage your mild pregnancy aches and pains which otherwise could lead to prolonged discomfort.

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You may have noticed that there is a lot of marketing and promotions done by cord blood banks nowadays. But what is a cord blood bank exactly? Well, it is a medical bank where doctors extract the hematopoietic stem cells (HSCs) from the newborn umbilical cord and can be preserved indefinitely. You can bank the cord blood in a private or a public blood bank and can be used later on to treat diseases and illnesses. This may sound like a wonderful medical breakthrough, but there are many myths about private cord blood banking making the rounds. Let us have a look at these myths and break the misconceptions clouding the minds of parents-to-be.

Can It Harm My Baby Be Harmed?

Collection of cord blood is in no way harmful to the baby or the mother. The blood that is discarded after birth normally is collected and stored at the cord blood bank.

Private Cord Blood Banks May Send Our Baby’s Cord Blood for Research

This is a complete myth as private cord blood banks give exclusive accessibility and control to the cord blood you store. They charge you annually for storing the cord blood and will give you access as and when you require it in the future. Unlink public banks wherein the blood may be sent further for research purposes.

Choose Any Cord Blood Bank, They Are All the Same

Wrong. Private blood banks have to follow stringent norms in terms of quality, cost, location, and need to be FDA-approved and AABB-accredited. However, not all private blood banks have DA approval and AABB-accreditation. Those who have both, have high annual storage fees and better facilities to store your baby’s cord blood for a longer duration.

It is Always Better to Store Cord Blood in Private Banks

Many to-be parents often think storing their baby’s cord blood in private banks is better than donating it to a public bank. If your family has a history of certain diseases and disorders, then choosing a private blood bank may sound logical. However, there is no such history and you don’t even know if you will ever need to access the stored cord blood, then donating the cord blood to a public bank is a wise decision.

You Can’t Treat Your Child With His/ Her Own Blood as it May Be Diseased Itself

This statement does not hold much ground as autologous transplants have been in use for more than a decade. Use of one’s own stem cells has helped in the treatment of many diseases ranging from neuroblastoma, lymphoblastic leukemia, etc.

Cord Blood can Remain Viable Only for 10 Years

Current studies have shown, stem cells stored for about 24 years remained viable without any decrease in viability or proliferation. It is even claimed by cryopreservationists these cells can be stored indefinitely in a controlled environment.

Cord Blood Banking And Ethical Issues

According to the Indian Council of Medical Research (ICMR), there are certain issues related to the self-use of cord blood as promoted by cord blood banks. The ICMR guidelines for stem cell research (2013) states there is no scientific basis for preservation of cord blood for future self-use. Thus, this practice is not officially recommended and any use other than bone marrow transplantation apart from clinical trials is termed as a medical malpractice.

You Can Decide About Cord Blood Banking Just Before You Deliver

It is not a good idea to make a last-minute decision in most of the cases. Your hospital may not have a cord blood collection kit ready during the child’s birth. There are many logistics that need to be figured out before you can store the cord blood. Thus, make sure you enroll early to a cord blood bank of your choice for smooth and hassle free collection during the birthing process.

These are few of the common cord blood myths that are busted above. Cord blood does have many benefits in cases where there is a family history of leukemia or thalassemia. However, it will remain as a personal choice whether or not one should store the cord blood.

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So far, we have got to know about the positive applications of stem cell therapies, which are transplanted into the body with living cells to treat, or eliminate the disease from the patient’s body. The most common type of cell therapy is the hematopoietic stem cell therapy. Harvested from the donor’s body for the host to develop bone marrow, it is a well-known cell based therapy, with its self-renewal and differentiation capabilities into many cell types.

Stem cell based therapies have the potential to treat numerous disorders, especially blood and immune related disorders. A wide range of stem cell therapies including allogenic stem cell therapies, autologous therapies, and mesenchymal stem cell therapies has shown a major breakthrough for curing many medical conditions such as sclerosis, spinal cord injury, diabetes and strokes in the clinical trials. More recently, we have the boon of induced pluripotent stem cells, having the same characteristic as adult embryonic stem cells that can be cultured to produce embryonic stem cells. These cells are important for another key reason- tissue engineering.

Over the last few decades, cell therapies have received medical and commercial successes for emerging as a novel therapeutic option for many cellular dysfunctional diseases. If data are to be believed, the global market of stem cell therapy had touched an average of $410 million revenues by 2009, and the market was expected to grow double and reached a total of 100 million people in the US.

And due to its numerous medical benefits, medical companies and research institutes want to bring its clinical applications from bench to bedside.

Although open to many controversies and debate, we have enough evidence to prove that stem cell therapy is indeed an effective therapeutic application to address a range of diseases, including cosmetic procedures like hair regrowth, skin redefining and etc.

In addition to this, the growing number of cell based clinical trails hold true to the potential for stem cell efficacies and its applications. A recent study as of June 2010 highlighted the capabilities of cell therapies through 2000 (approx.) clinical studies on biomedical research.

While the manipulation of embryonic cells is limited and controversial, a greater chance to develop engineered tissues from iPSC is viable for the medical interventions in serious conditions. And this is the underlying reason, why public and society demand for more clinical trials of stem cell based therapies and their applications in the medical fields.

Hence, it is important to commercialize the use of stem cells for rapid development of biomedical research, and improve public health through awareness. Some important aspects of the commercialization of stem cell therapy are as follows as below.

• Commercialization aids the development of novel technologies and intellectual property for certain stem cell research, augmenting their value in the therapeutic market.
• It aims at stimulating economic growth as well as improving the public health.
• It advocates for grants or funds to be used in the clinical research to generate more commercially viable services and products in the market.
• It is indeed important for the translation of public knowledge.

Despite these growth factors of commercialization of stem cell therapies, it faces many challenges from specific governing bodies, which hinders its positive endeavors from creating effective and curative treatments for many incurable diseases.

In order to take advantage of scientific, economic and medical potential of stem cell research; commercialization is indeed a basic requirement, and of course in a compliance with regulators of certain authorities. And when this happens, we would expect to get sustainable and constructive medical benefits through commercialization in the field of stem cell therapy, while respecting the public trusts.

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Over 50 million people suffer from arthritis in USA alone. Arthritis is a common enough disease among the elderly, which makes it difficult to even undertake the basic chores like holding a spoon, eating, and walking. Arthritis degrades the cartilage between the bone joints making it a painful and debilitating condition. Over time the body is unable to heal the degeneration of the bones. All that the doctors can only do is to help reduce the pain. Many cases are managed just with the help of therapy, and surgery is only performed in severe cases.

Mesenchymal stem cells (MSCs) are found in the bone marrow. The fat and blood in our body helps create cells of various types these include cartilage producing chondrocytes cells. These cells help in restoring arthritis affected joints. There are many sources of MSCs. Muscle-derived MSC is a cell source and sources are placenta, amnion, umbilical cord blood, and ear elastic cartilage.

Injecting MSCs into a joint cartilage has shown effective results. But the puzzle has not been deciphered so far as to how the stem cells work to repair the damage. MSC is said to release a protein factor which in turn helps the body repair its own cartilage damage.

Chondral injury also leads to small and long-term disabilities. There are many surgical treatments available. The cell therapies utilize stem cells by differentiating the many mesenchymal phenotypes and maintaining their multi potency. The MSC is delivered into the knee or injury site through an injection.

There are various tissues in the human body which contain MSCs. These are harvested from the bone marrow, adipose, synovium, and umbilical cord.

Clinical trials have given satisfactory reports on cartilage regeneration after the stem cell implantation. Collagen, polyglycolic acid, hyaluronic acid, and silk fibroin enhance the healing process. They have superior histological and mechanical properties.

Bone marrow-derived stem cell chondrogenic potential has been confirmed by the cell culture studies. Adipose tissue is harvested usually from the patient’s buttock region with the help of tumescent liposuction.

Chondral defect seen in early osteoarthritis knees that were implanted with MSC suspension alone or MSCs with a fibrin glue scaffold have shown better cartilage regeneration than the control group. A final follow-up done after a period of 2 years has shown that results have improved in both groups. While the arthroscopy has revealed better cartilage repair in knees that have been implanted with MSCs and scaffold.

Synovial tissue is another alternative source of stem cells which is utilized for cartilage repair procedure. Two studies have reported about the clinical results of synovial tissue-derived MSC.

Peripheral blood-derived MSCs (progenitor cells) are obtained from peripheral blood. In this procedure the bone marrow the iliac crest is taken at the time of cartilage repair surgery. The harvested bone marrow is then centrifuged, and the bone marrow concentrate is obtained. During the surgery itself, the concentrated aspirate is then transplanted at the chondral defect along with hyaluronic acid or collagen.

Cartilage regeneration is due to many various growth factors and biofactors like insulin growth factor, transforming growth factor-β, and SOX9 which enhance chondrogenesis of MSCs, and gene transfer. Healing is enhanced by these growth factors and because of gene transfer as well as pluripotent cells.

Sources:
https://insight.jci.org/articles/view/87322/version/1/pdf/render
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345159/
https://blog.cirm.ca.gov/2017/11/02/clever-technique-uncovers-role-of-stem-cells-in-cartilage-repair/

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We know how antibodies perform in our body to restrict the foreign invasions, so that we can protect ourselves from various illnesses caused by viruses and bacteria.

Other than these usual physiological activities, they are found to have lent their hands in the development of Induced Pluripotent Stem Cells by using external parameters. This, we can take as a major breakthrough in the field of medical science, which could be effective in producing different drugs, and medicinal therapies to combat a range of diseases.

In a recent research by the scientists at The Scripps Research Institute (TSRI), it has been proved that antibodies could be a useful component to a new approach as “reprogramming” ordinary adult cells into stem cells or induced pluripotent cells. And to do the “reprogramming” techniques into the DNA’s of the adult cells, no invasive procedures are needed to be followed as is with the “reprogramming of stem cells in the human body”.

We already have an insight into how induced pluripotent cells act to differentiate into any cell types and proliferate in the body. With potentials like self-renewal, iPSCs are ideal to be used as a model to identify the etiology of diseases, find new drugs or therapy using stem cells of patients. However, the same functions can be executed by the human antibodies too. This is what scientists at the Scripps Research Institute (TSRI) have focused on this new development. The finding of the study has been made available online in the Nature Biotechnology.

Why Antibodies are Better Than iPSCs?

The process of developing iPSCs involves a manipulation of the genome in the DNA of fibroblasts, found in the skin or connective tissues. These cells could easily be converted into stem cells or iPSCs by adding four transcription gene factors of the DNA of these cells. However, the antibodies as found by the scientists do not follow the same path once introduced to the mature cells, and replace three key transcription gene factors to bind to the proteins of the cells.

Using four transcription genes,s including Oct4, Sox2, Klf4 and c-Myc into the nucleus of the mature or adult cells derived from the patients’ own cells, iPSCs are developed for a variety of medical purposes, say organ regeneration or cell therapies. There have been a few evidences of risks of producing iPSCs cells, hence we fail to experience much practical use of these cells in the medical field.

The development of iPSCs cells depend on the OSKM theory, meaning using these four protein factors and encoding them, they reprogram cells into induced pluripotent cells.

However, the insertion of those proteins into the genes can invite the attack of viruses, or overproduction of nuclear manipulation techniques may cause cancer to the DNA cells. On the other hand, the production of iPSCs through nuclear reprogramming fosters the collections of different variable properties.

While antibodies do not use any extra DNA as iPSCs to reprogram mature cells into stem cells or iPSCs, it takes into account only three key transcription gene factors excluding the fourth transcription gene factor Klf4.

Hence, iPSCs derived from antibodies could have fewer mutations, and better properties to be used as an effective model in the lab.

The Process Of The Study

The research was carried out on a collection of 100 million human antibodies to examine if any of the antibody could develop iPSCs by replacing OSKM transcription factors. The process was examined on the fibroblasts of mice, and cultured in the lab using first two factors of OSKM such as Oct4 and Klf4. Later on, the entire library of antibodies was placed in the culture tray to find a replacement of functions of other two gene factors such as Sox2 and c-Myc. The study had a positive outcome with a development of iPSCs with antibody triggering the DNA sequencing response. It focused on the replacement of Oct4 using the same technique. However, it was not possible to find any replacement of fourth transcription gene factor Klf4.

The objective is now more concentrated on finding a fourth gene factor replacement to make the whole process shifted on antibody’s insertion for iPSCs production. And once we would be able to do it, we will have less number of negative outcomes.

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While pregnant moms have a tendency to do weird stuff like eating, doing stuff on whims but expectant mothers are always given specific instructions regarding household work. There are many chores that are not safe for to be moms. You will have to stop doing them completely. No safe limit is demarcated in lifting weights, they are a no go.

You will be facing back strain from carrying the baby in the womb as the center of gravity of your body changes. And if you lift weight while carrying the baby, or groceries, move gas cylinder, or heavy furniture it will put your back under strain. Some doctors recommend not lifting weights as it may trigger bleeding, premature labor, or rupture of the amniotic sac.

When working with chemicals like cleaning products, do remember to wear gloves. Make sure the room is ventilated and try to use safe cleaners like baking soda and vinegar. Harsh chemicals like mosquito spray, bleach, cleaner lead to noxious fumes all around. Wear gloves while washing dishes and while vacuuming it can be very tiring as the filter contains dust, spores, and hair which will get in your lungs and eyes. Do not clean the cat litter. Cat feces carry toxoplasmosis a rare disease. Do not inhale second hand smoke which carries over 4000 chemicals.

Wash the vegetables thoroughly before eating them. They may be contaminated with chemicals, soil contaminated by wild or pet animals.

Chores that require climbing and balancing is not recommended. Do not climb stools, ladders, or reach out for stuff on a loft, shelf or kitchen cupboard. You may be nimble otherwise but during pregnancy you may not be your usual self and may fall. Get your maid or close relative to help you out to clean ceiling fans, windows, mirrors, change bulbs, electrical fittings for which you can call an electrician.

If you sleep on the floor request a family member to help pick up the mattress, quilt and bed linen. Bending and picking up stuff will affect the back. Washing clothes, scrubbing the floor all affect the back. Squat rather than bend to do stuff.

Also try not to stand for too long. Pull up a chair and sit down at the table or close to a television to chop the vegetables. Take a break and then complete your work. Try and prepare dishes that do not require you to stand for long.

Divide the household duties. Do safe chores to get some exercise when pregnant. Being pregnant is not really a reason to keep your home dirty; but take help. You may want to prepare for your newborn but may have pregnancy complications. Keep your safety in mind. Being safe is important so you can enjoy a healthy and sound pregnancy. Your body undergoes many changes and you need not put it under a lot of strain.

Women who are healthy need to stay active for better pregnancy. Non-stimulating work around the house leads to giving birth early by three weeks. Researchers believe that stress hormones trigger labour.

Sources:
https://www.babygaga.com/household-chores-that-are-best-avoided-during-pregnancy/
https://www.babycenter.in/x1024655/can-household-chores-be-dangerous-during-pregnancy
https://timesofindia.indiatimes.com/life-style/relationships/parenting/Moms-to-be-Household-work-can-be-harmful/articleshow/6002586.cms

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A new study has inched us closer to designing a new lung with the help of bioengineering. A team of bioengineers has successfully created a functional lung with a healthy, perfusable vasculature in an ex vivo rodent lung.

End-stage lung diseases are the third leading cause of deaths around the world. It has only one true cure, a lung transplant. This is not always an option for a majority of the patients as it is an expensive procedure with a survival rate of just 10% to 12% after 10 years. Finding a donor’s lung is also very difficult and thus, there is an urgent need for new approaches to saving lives.

Bioengineering a Functional Lung that Breathes
Researchers around the world are looking for ways to cure lung diseases by promoting lung repair and increasing the number of donor lungs. However, lungs are a complex organ with more than 40 different types of cells in the matrix. The surface area between the airway and the vasculature is the size of a tennis court. Thus, bioengineering a functional lung from synthetic or decellularized scaffolds is not an easy task.

Until now all attempts to create a lung have failed. However, a Columbia Engineering team led by Gordana Vunjak-Novakovic, University Professor and the Mikati Foundation Professor at the Columbia University along with N. Valerio Dorrello, assistant professor of pediatrics at Columbia University Medical Center have finally tasted success to an extent. They are the first to successfully bioengineer a functional lung with perfusable vasculature in an ex vivo rodent lung.

Their study (DOI 10.1126/sciadv.1700521) has been published in Science Advances, wherein they talk about how their approach allows the removal of pulmonary epithelium while maintaining the viability and function of the lung matrix and the vascular network.

The New Approach

The Columbia team did not follow the traditional approach of building an organ. Usually, an organ is built from scratch by manufacturing a synthetic scaffold that resembles the shape of the organ. It is then seeded with the stem cells or other precursor cells. As lungs are a complex vascular jungle, most bioengineers have not attempted to build one. However, the Columbia team generated a natural scaffold by removing the rat lung cells using detergents. This led to a lung ‘skeleton’ consisting of proteins and molecules called extracellular matrix to remain.

The team in their previous experiments using rat lungs stripped the epithelial lung cells that are usually damaged in lung diseases. They also removed the endothelial cells that make up the vascular system. The team has managed to repopulate the functional epithelial cells; however, restoration of the blood supply was a challenge.

The new approach, therefore, attempted to strip only the lung epithelial cells without disturbing the blood vessels. They hoped this approach would lead to better results. The researchers tried an airway-specific method for removal of the pulmonary epithelium. They even aimed to preserve the lung vasculature, matrix, fibroblasts, myocytes, chondrocytes, and pericytes.

After the lung cannulation, they ventilated the lungs and perfused them on an EVLP (ex vivo perfusion system). Intratracheally, mild detergent solutions were injected into the isolated lung for removal of the epithelial cells. The vasculature was protected by circulating a perfusate containing electrolytes and energy substrates. The result was a lung scaffold that had a well-maintained bronchial and vascular architecture. The attachment and growth of human adult, as well as the cell-derived pulmonary cells in the ex vivo bioreactor, becomes possible due to the well-preserved architecture.

The building of a functional lung has become a breakthrough step in the field of bioengineering that has opened many frontiers in regenerative medicine.

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The bonding between babies and parents has its journey. The attachment that a child develops towards his/her parents is born out of instincts and everyday togetherness. Out of this bonding is born a sense of belonging towards each other.

There are moments when an infant instantly bonds with his/her parents. And there are times when bonding becomes tough. According to a study that was published in 2014, sometimes there’s a chance of every one in four children not bonding with their parents at all. This is undesirable both for parents and their little one.

Sometimes Bonding Takes Time

If you and your child haven’t been able to bond well, take heart! Bonding is always not instant. There are many factors influencing it. Mother’s who’ve had a C-section delivery often finds it tough to bond with their child. They aren’t always able to embrace their babies’ right after birth. At times, this is where a psychological gap gets created. Furthermore, babies who are born premature have to spend more time in the intensive care unit. This keeps them away from their mothers and result in a delayed bonding.

Usually, fathers too take time to bond with their baby as they don’t nurse the infant as a mother does. Also, they don’t get to share a skin-to-skin closeness with the baby. Since, most fathers are the earning members of the family, they usually spend more time away from the baby. By taking part in simple baby care tasks such as changing the diapers, helping to prepare the baby food, bathe the baby and also spending time comforting the baby, can aid and help in creating a strong bond.

Things Mothers Can Do to Bond With Their Babies

The best thing is to be with your little one as much as possible! Start by asking the medical staff to share room with your newborn right after birth. Just in case your baby is kept in the NICU (neonatal intensive care), try to visit your baby as much as you can. Take permission to hold your baby, talk to and sing for your baby. Few new mothers resort to a sling or a baby carrier so that they are able to keep their little ones close to them. Resort to this over a stroller as much as you. Babies love it when they are close to their parents. They feel warm and secured. As your baby grows, try and go out for a walk or grocery shopping with him/her. This will help the little one explore the world with you and help you both to bond better.

Things Fathers Can Do to Bond With Their Babies

Start before your little one is born! Accompany your wife to the doctor visits and tests. At times place your hand on your wife’s belly to communicate with your little one, growing inside the womb. When your wife gets the labour pain, be there beside her and do all that you can to help. The moment your new born is home spend time to prepare the room, getting the baby care products arranged, at times feeding the baby and help in other errands as well.

However, sometimes either or both parents need to make it to the counsellor or physician’s office when things go awry. For instance, if psychological and emotional factors like detachment or lack of feelings are your concern, then seeking expert help is essential. Sometimes, unreleased and pent up emotions of sadness, fear and dejection block the channel of unconditional parental love. Know that everything is treatable. And know that with time, faith, positive intention and expert medical guidance, you can fight through it all.

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There have been many treatments and studies that suggested excessive burst of new brain cells after TBI helped in the recovery of the patients better. Breaking this common assumption, Dr. Viji Santhakurmar (Associate Professor in the Department of Pharmacology, Physiology and Neuroscience, Rutgers University) and her colleagues proved otherwise with their report. They challenged this assumption and found that an excessive neurogenesis may, in fact, lead to memory decline, seizures.

Neurogenesis after Brain Injury May Lead to Memory Decline, Seizures

It has been proposed that increase in neurogenesis aids in the repair of the injured brain network. However, survivors of traumatic brain injury often develop life-changing disorders such as a decrease in memory as well as epileptic seizures.

Researchers found there was a considerate increase in the new nerve cell growth (neurogenesis) that was probably to help replace the damaged or destroyed brain cells. However, Santhakumar and her colleagues found evidence contradictory to the popular belief. They found the spike in brain cell growth may, in fact, lead to post-injury seizures and long-term memory decline.

This team from Reuters University examined brain injuries in lab rats and found that brain cells at the injury site play an important role. These cells double in number within 3 days after injury; however, they decrease by more than half after a month as compared to rats with no brain injury. The neural stem cells develop into mature cells too showed a similar increase and decrease pattern. Thus, proving they were responsible for the loss of brain cells.

As quoted by Professor Viji Santhakumar in a press release, “There is an initial increase in birth of new neurons after a brain injury but within weeks, there is a dramatic decrease in the normal rate at which neurons are born, depleting brain cells that under normal circumstances should be there to replace damaged cells and repair the brain’s network. The excess new neurons lead to epileptic seizures and could contribute to cognitive decline. It is normal for the birth of new neurons to decline as we age. But what we found in our study was that after a head injury the decline seems to be more rapid.”

According to the study, post-injury changes in the development of new cells along with the neural precursor cell proliferation led to a long-term decline in the neurogenic capacity. When the post-injury neurogenesis was reduced early on resulted in dentate excitability and seizure susceptibility.

To achieve this goal of slowing down nerve cell growth after injury, researchers used anti-cancer drugs that are under clinical trials currently. These drugs are known to block the growth and survival of new nerve cells. The drugs were able to stop the rapid proliferation of the nerve cells and prevented the long-term decline in brain cells that lead to memory decline in lab rats. It also showed the rats had reduced risk of seizures after administration of these drugs.

Dr. Santhakumar says that they believe in limiting the process of rapid growth of nerve cells will prove to be helpful in stopping the seizures after brain injury.

These findings spark hope for those with TBI that one day these methods will definitely help in reducing the short-term and long-term symptoms that alter the life of the patients after a challenging injury to the brain.

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How would it have been if we could develop embryoid bodies (EBs) from individual embryonic stem cells (ESCs) using technology? This could give birth to the development of the regenerative medicines and other therapies, which does not require an external supporting matrix as needed by the traditional regenerative technology to create a coordinated assembly.

All this is possible with a cellular magnetic Legos. A technology developed by the researchers at the Laboratoire Matiere et Systemes Complexes (CNRS/Universite Paris Diderot) is capable of combining cells with the help of magnetic nanoparticles and magnetized miniaturized magnets. In order to differentiate, it does not need any supporting matrix. The best part of this technology is that it can develop any tissues and deform them at will.

An elaborate insight of the study has been detailed in Nature Communications. This tool infused with miniaturized magnets can be used as a great technology in the field of regenerative medicines and also in biophysical studies.

Since the demand of nanotechnology is ever growing for providing an unprecedented solution for diagnosis and regenerative therapy, we can feel its necessity in every sphere of medicines and biosciences. Hence, this finding is another milestone for the development of regenerative tissues or therapies sans an external supporting matrix.

However, for scientists it is not viable to use matrix for the development of cohesive and organized cellular assembly for tissue generation. This is what they find it a great challenge, especially when they have to work on synthesizing thick or large sized organ or tissue. Or sometimes, the stimulation of these tissues is quite tough as they refuse to function properly as opposed to their counterpart cartilage.

Magnetic Cellular Lego At Scientists’ Assistance

A new tool developed by the scientists in France, uses magnetized stem cells to alter and stimulate stem cells into 3D shapes. By using external magnets, cells can be magnetized for differentiation, assembly, proliferation and stimulation through insertion of nanoparticles. This way, these cells are turning into cellular magnetic Legos. The magnetic Legos performs as a magnetic tissue stretcher, where mobile magnets captivate aggregate developed from the cells before a second the micromagnet could attract magnetized cells. The experimenting tissues on the magnetic tray behave independently (say compression and stretching) influenced by the two actuated magnets.

The Method Of The Experiments

The first approach of the study was to gauge the capacity of the magnetized cells to differentiate and proliferate as similar as stem cells, and also zap pluripotency characteristic in embryonic stem cells when introduced to nanoparticles. It was aimed at developing the embryoid body applying the differentiation process of embryonic stem cells. We can call embryoid bodies as 3D groups of pluripotent stem cells, which comprise three types of skin cell types. The team further found that nanoparticles do not impact the formation of embryoid bodies in the magnetic stretcher.

In order to form embryoid bodies using magnetized cells, it has more effective outcomes as opposed to the hanging drop method, where embryoid bodies cannot proliferate properly.

The study further showed that the addition of the nanoparticles to the embryonic stem cells do not put any impact on its differentiation process. Simultaneously, the embryoid bodies could move toward the heart muscle in the magnetic stretcher when stimulated by magnetic cells. Thus, it proved that other than living orgasmic cells, the mechanical factors like magnetic cells can take part in the process of cell differentiation too.

We can hope that by using this all-in-technology, we can generate tissues by manipulating stem cells, or use it as a powerful method to enhance biophysical learning possibilities.

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A recent study by the Stanford research team has concluded that the immune cells send muscle injury signal to activate stem cell regeneration.

Immune cells activate cells for muscle regeneration and repair which will aid in treating muscle disorders. Studies indicate that a gene Adamts 1 gets switched on in the satellite cells. This is a secret protein that activates satellite cells in case of muscle injury.

But the Adamts 1 does not appear to produce the protein at the injury. There is a white blood cell called macrophage (literally means eaters) which is responsible in producing the protein at the injury site. They travel to the wound and keep it clean and healthy by eating bacteria, the dead cells and viruses. They also release protein to alert the immune system to fight the infection.

While cleaning the wound it also signals the muscle to regenerate. The Adamts 1 also nips a protein known as NOTCH which is found on the satellite cell surface. NOTCH indicates to the satellite cell to stay dormant. When Adamts 1 destroys NOTCH, the satellite cell gets activated, and starts to divide and transform into muscle cells.

There is a direct link between the cells that clean the injury and they also signal it to start regenerating and rebuilding the muscle that was destroyed. This facet is present only in the uninjured muscles.

Macrophages release Adamts 1 which nips the protein of the NOTCH which keeps them in a restful stage. When NOTCH is deactivated the cells start making new muscle.

Mice that have been tested for this Adamts 1have shown a curious case. It is seen that they have more muscle damage and the muscle stem cells reduce over time and Adamts 1 becomes less capable of repairing the damaged muscle. More importantly it is just one cell that is able signal to the muscle stem cells and stimulate it to differentiate muscle.

Satellite cells are also called muscle stem cells. These lay inactive and only come into action when there is an injury and damage from it. The satellite cell function breaks down due to aging and diseases like muscular dystrophy. These satellite cells drastically reduce in number and also cannot divide any longer which leads to muscle degeneration.

The research also says that the satellite cell plays an important role in its activation. The study gives a deep understanding of muscle regeneration, and repair that will help in the development of new treatments for various muscle disorders.

Previous studies on a gene called Adamts 1 suggest that it is turned on strongly in the activated satellite cells than the dormant satellite cells. Most important is the fact that a single protein is enough to send a signal to the muscle stem cells and stimulate them and they can differentiate muscles. This makes it a natural mechanism which can be manipulated to help support the efforts of healing and building therapies to improve health drastically.

Sources:
https://blog.cirm.ca.gov/2017/09/27/an-unexpected-link-immune-cells-send-muscle-injury-signal-to-activate-stem-cell-regeneration/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323685/
https://blog.cirm.ca.gov/?s=%22satellite+cells%22+OR+%22muscle+stem+cells%

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Parents know that the growing years of a baby has its own challenges. Everyone wants the child to grow healthy, strong and fit. And when it comes to the food and vitamins intake of your baby, you’ll probably get to hear varying views from everyone you encounter. Whether it’s your new mom buddies in the neighbourhood, your relatives, the lactation expert or even an online health news report – the versions concerning babies and vitamins will differ. When you are trying to figure out what vitamins to add to your baby’s diet, all these views can be overwhelming to decipher. However, a good place to start is by asking a crucial question – “Does your baby need any vitamin or supplement”? And that would depend to a great extent if you are breastfeeding.

The Truth About Breastfeeding

Mothers’ breastfeeding their babies assume that it’s the apt food for their babies and is replete with all the vitamins needed. Whilst it’s true that breastmilk itself carries the necessary vitamin component, it doesn’t have two core nutrients in sufficient proportion – Iron and Vitamin D. The latter is a must have for a kid for stronger bones. And iron is crucial for the development of a healthy brain and blood cells. Babies also require this mineral to avert any kind of iron deficiency and anaemia.

Babies who consume a wide mix of foods as they grow, doesn’t need any vitamins other than breastmilk. However, there can be exception to this rule. For instance, if a baby was prematurely born, small for the gestational age, low birth weight and consumes less breast milk as compared to other babies then they would need vitamins and supplements. Also, if the baby has chronic health issues that result in poor eating habits, then it is necessary to chalk out a proper vitamin intake chart for the little one.

The Health Of The Mother

In fact, when deciding on the list of vitamins that a baby needs, moms need to look into their health scenario as well! For instance, women having medical conditions like gastric bypass surgery or has been on medication on a regular basis, will absorb less nutrients from their food intake. This results in nutrient quality of the breastmilk to be low as well. Also, if you happen to following a vegan diet, inform the healthcare provider. Iron, calcium, vitamin B12, zinc and the omega-3 fatty acids are few of the nutrients that vegan moms and their babies should be working on. Alternatively, a multi-vitamin mineral supplement could be the fix.

Vitamin B12 and Fluoride

Vitamin B12 is essential for the proper development of the nervous system and reduces the occurrence of anaemia. Moms can find this vitamin in milk, milk products, eggs, poultry, meat and fish. If you don’t eat adequate animal proteins and you are breastfeeding, then it’s essential for your healthcare provider to suggest you an ongoing and proper source of Vitamin B12. This way you can ensure that your baby too is getting this supplement through you.

In the recent times there has been very less medical proof whether fluoride supplements at the time of infancy enhance baby’s dental health. The American Academy of Paediatrics suggests that all kinds of fluoride supplements should be given to the baby after 6 months. Also, it should be given to only those children who integral water source is weak in fluoride.

Summing It Up

Majority of babies get their minerals and vitamin intake from the breastmilk and post that the other supplementary edibles that go along with it, with just an exception of Vitamin D. If a baby isn’t taken to sunlight on a daily basis then the chances of Vitamin D absorption are low. Also, iron supplements are essential for preterm babies. And Vitamin B12 is a must for babies born out of vegan mothers or who experienced bariatric surgery. With this knowledge at hand you and your healthcare provider can work out the rest.

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If you are giving birth to a child for the first time, the reality of “labour hurts” is something you must have heard before. And if it’s the second time you are pregnant, then you have already witnessed it! Being able to bring forth a new life on the face of earth indeed takes a lot out of a woman, both mentally and physically. However, in today’s new age way of life, where there’s a revolutionary solution to almost everything, is there at all a thing called “easy labour”? The answer is yes! The truth is, labour can be made less painful and stressful for a pregnant woman by following certain techniques. Discussed below are some of the useful ways.

Practicing Yoga

Yoga is considered to be one of the best prenatal exercises that go a long way to ease labour pain! Yoga practitioners assert that multiple yoga postures set up the body in a unique way to be upright in labour. The postures of squatting, kneeling, standing, knee and hand work hand in hand to ensure that the pelvis is loose and open for an easy positioning and birthing of the baby. There’s another benefit as well. Concentrating on the breathing, eases labour. Focusing on exhaling and relaxing and then inhaling again teaches your body to erase the tension and breathe in a relaxed manner during labour. Pilates is also a good exercise to opt for.

Consuming Dates

There has been proof that women who ate 6 dates everyday for a stretch of 4 weeks before their delivery date have been likely to experience spontaneous labour, a very minor stage of labour and also experience a higher cervical dilation when admitted to the hospital. This was not the case with the women who didn’t consume dates for the mentioned time. So, eating dates is considered beneficial for easier labour.

Starting Kegels Exercise

Kegels exercise is very easy to practice and it results in ample benefits! It’s done by contracting and then releasing the pelvic floor muscles. The easiest way to go for it is simply by imagining how you would hold up your urine. This exercise enables the body to strengthen the muscle that helps to push at the time of labour. One can start this exercise anytime during any stage of pregnancy. Simultaneously, post child birth continuing Kegels exercise will make the exhausted muscles stronger.

Taking Perineal Massage

The obvious benefit of perineal massage is that it helps to stretch the tissue at the vaginal opening very gently. It is suggested that this massage minimizes a woman’s susceptibility to tearing whilst pushing the baby out of the womb. According to Paula Jaspar, who is a registered massage therapist, the perineum is composed of muscles, which takes ample time to become supple. She advises to start this massage very early. If a woman is 12 weeks pregnant, it’s the best time to start with perineal massages.

Drinking Red Raspberry Leaf Tea

Drinking red raspberry leaf tea balances the hormones and also tones the uterus. The tea is packed with Vitamins A, B, C, and E and minerals such as calcium, potassium and magnesium. Raspberry tea has been useful in minimizing the labour duration and also the requirement of medical interventions, for instance the requirement of forceps, C-sections as well as vacuum births. Consuming 3 to 4 cups of raspberry tea daily right from the third trimester is considered to be helpful.

Pregnancy and child delivery demands huge amount of physical strength and mental agility from a woman. An easy labour is something that every woman would want to experience, keeping in mind there’s a list of other bodily changes that occurs during this time. These 5 useful techniques can ensure an easy labour.

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Today, the miracles of cord blood cell treatment are making rounds globally! It has saved the health of adults and children suffering from life-threatening diseases, with less to zero chance of recovery. The likes of autoimmune diseases and leukaemia are few to name. 1998 was when the first cord blood cell transplant occurred. This was the starting point that encouraged families across the globe to have faith in cord blood stem cells to treat irreversible diseases back to normalcy. Success stories are a plenty today. One such story of a family who turned to cord blood banking cells to save their daughter is heart-touching and motivating.

Jesus and Karina DeLeon, today, consider public cord blood donation to be the blessing that helped them save their little daughter Valentina, who is 7 years now and is leading a healthy life. However, things used to be very grim before.

Valentina post 5 months of her birth was experiencing excruciating health conditions which propelled her mother to completely stop breastfeeding. The little one, all of a sudden developed digestive problems in the body. By 9 months of age Valentina was diagnosed with an acute lung infection. Her parents have been attempting have their baby for a decade and now that they have their little one, they feared the deteriorating health condition and were concerned if they would be able to save her.

Reflecting back on those dark days, Karina shares that she instinctively knew something was wrong with her kid and she used to record low-range fever almost every day. When Valentina was taken to the hospital her reports appeared shockingly abnormal. Both the diagnosis and prognosis shocked them. Post many blood tests along with a bone marrow biopsy, it was evident that the little one was affected with SCID, Severe Combined Immunodeficiency which is an uncommon genetic disorder making the immune cells function abnormally. With this Valentina’s survival chance was not more than 30%.

In their relentless attempts to save their daughter and also a bone marrow match, the family chanced upon a public cord blood bank located in San Antonio. They learned that cord blood cells comprise of hematopoietic stem cells that has the capacity to get converted into almost any kind of blood cell. On transplanting these cells to the bone marrow, they work as proper, functional cells and thus start to heal diseases, for instance immune deficiencies, blood imbalances, metabolic abnormalities, life threatening cancers and other unusual genetic disorders, even the one that Valentina was suffering from.

The process of cord blood storing is very easy and secure for both the mother and the baby. It has no adverse effect on either the labor or the delivery. Also, the DNA specimen that is required to procure the match can be managed with just one easy swab examination. The parents of the concerned child are required to inform the obstetrician that they want to donate. When no family record of genetic disorders is found, the cord blood which otherwise would have been discarded would be used by families that genuinely require it.

When it comes to public cord blood banking there is a higher chance that the donation is going to be used to treat some or the other critical medical condition. This is what Dr. Joanne Stone, Maternal Foetal Medicine Specialist, Mount Sinai Health Care, New York had to say as opposed to private banking, where only one family has the chance to use the cord blood cells, that too if ever there arises a need.

Parents like Karina and Jesus DeLeon has benefited with public cord blood banking. According to them, it’s always a great choice to simply go ahead and donate an infant’s cord blood cell for the sake of saving someone in this whole wide world. It’s the best humane gesture a human can show for humanity.

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Frequent ear infection, ear discharge in babies is a daunting problem for parents. Most of the time it is hard to detect if the baby has an ear problem because the baby cannot communicate. Let’s find out how ear infection builds up and which are its possible signs of identification.

What Causes Ear Infection in a Baby?

The ear has three parts such as outer ear, middle ear and inner ear. The middle ear is the space where infection happens and inner ear balances the nerves.

The outer and middle ear again has two parts known as eardrum, which gives signals to the brain through the Eustachian tube from the back of the nose.

Babies have small ear tubes connected to the nose and throat. Bacteria easily enters into these small tubes in a sick condition such as a cold.

Generally, in the ears, any liquid gets drained by eustachian tubes. Sometimes because of cold, sinus or allergies, the eustachian tubes get blocked. This condition causes germs to start growing that infects the ear, which babies find painful. It may also end up causing fever.

Here Are The Signs of Ear Infection in a Baby

• Babies pulling at the Ear: Watch out when babies are frequently pulling at their ears; it could be a sign of an ear infection. Ear infection causes pain, discomfort. Hence, babies try to reduce the pain by trying to pull their ears.
• Yellow Pus: Be sure that the baby is experiencing an ear infection when you see yellow pus or bloody fluid coming out of the baby’s ear. Fluid comes out of the ear when eardrum gets ruptured because of more fluid.
• Difficulty in lying down: When a baby with ear infection lays down the fluid inside the ear changes its pressure, which is quite painful for the baby and so the baby is unable to sleep soundly.
• Baby cries more: More ear infection causes extreme pain and makes the baby irritated. Baby cries for many reasons, but you can compare other ear infection signs to be absolutely sure.
• Limited Appetite: Ear Infection makes it uncomfortable to swallow or chew food. You may notice that the baby pulls away from the breast or bottle after taking only a few sips of the milk. This condition reduces the baby’s food intake and creates a gastrointestinal upset, diarrhoea and vomiting.
• Fever: When the baby has a temperature of 100 F, it is necessary to check other common symptoms as the body is trying to fight a possible ear infection.
• A runny Nose: It is one of the signs that indicates an ear infection. Ears are directly connected with the nose and the throat. Therefore, there is a chance that the bacteria may have travelled to the ears and infected the same.
  Ear pain could be a risk to the baby’s health. Often, timely observation of the baby’s ear problem can save the condition from massively escalating into an inflammation. Mild ear problem can heal on its own. If in 2 -3 days of time baby is still showing much discomfort, then you will need to see a Paediatrician or an ENT specialist.

As we know that the baby’s health is delicate. Therefore, it is better to check with the doctor before trying home remedies such as warm compression or a painkiller.

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Simply put, Leukaemia is a kind of cancer that results in the abnormal production of white blood cells in the body. The only successful treatment that had been known for it is chemotherapy, which keeps it under check. But the recent medical developments have witnessed the use of cord blood stem cell treatment for Leukaemia patients that aren’t cured by chemotherapy alone.

Understanding Leukaemia

This disease is a cancer caused in the bone marrow that gradually leads to a very weak immune system. Individuals affected with this disease often experience infections. Furthermore, the white blood cells that are produced rather abnormally starts cluttering the bone marrow prohibiting the generation of other kinds of blood cells that further causes bleeding, bruises and also anaemia.

How Cord Blood Stem Cell Can Treat Leukaemia?

A cord blood stem cell transplant engages managing high amounts of chemotherapy and in some situations radiotherapy to kill the cancerous cells that’s in the patient’s bone marrow and blood stream. The new cord blood stem cells that have been transplanted to the body gradually learn to settle in the bone marrow, gradually giving birth to the healthy blood cells. This treatment is only applicable for patient’s that have a critical case of leukaemia.

A Story of Hope

The medical globe has been buzzing with success stories of cord blood stem cell transplant that has cured many chronic ailments. Leukaemia being one! Here’s the account of Lukas Waterman, who happens to be a doctor at the Washington University School of Medicine in St. Louis that induces hope and courage. Lukas was first detected with acute lymphoblastic leukaemia (ALL) back in 2003. And since then the man has resorted to almost 70 drugs to heal the disease and opted in for two bone marrow stem cell transplant to combat his cancer.

His very first stem cell transplant donor was his brother. Along with the immunosuppressive drugs this transplant seemed to have been successful without any complicacies. However, after a couple of years the cancer came back which made Lukas go in for a second stem cell transplant from a donor not in the family tree. And though this transplant too had worked for him, it made him attract another chronic ailment known as the graft vs host disease (GVHD). This means the stem cell transplant that had actually healed him was now violently attacking his body. Sometimes GVHD is a natural off-shoot of bone marrow transplants.

In GVHD the transplanted immune cells of the donor, medically termed as the T cells start to grow and then attack the tissues and cells in the body, as it appears to them that it’s an alien invader. In almost 50% of bone marrow stem cell transplant GVHD is a possible occurrence that has an adverse effect on the liver, skin, intestines, mouth and eyes. However, there’s hope for this! A promising stem cell therapy named Prochymal that has been developed by Dr. Randy Mills, former CIRM President and CEO, Osiris Therapeutics is known to heal extreme cases of this disease. Presently, this treatment is in use and being experimented on the phase 3 trials for young children’s and adults in US.

However, individuals like Lukas Wartman are a real inspiration to people that have attracted GVHD and have suffered from Leukaemia. He is also a reason why most medical researchers are practising to arrive at advanced treatment for this ailment. No doctor wants patients to suffer either from Leukaemia or GVHD quietly for a prolonged time. The account of Lukas Wartman is a reminder to the medical sphere that there’s immense work to be in the domain of stem cell bone marrow transplant to ensure that the adverse side effects are kept in control and patients don’t have to fret about contracting another disease in an effort to treat one.

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The medical world is buzzing with success stories of how cord blood stem cells have been used to heal a cluster of ailments, from leukaemia to Type 1 and 2 diabetes and many more. This is has made parents-to be consider cord blood banking when their baby is born. The objective is simple! In a world where ailments can strike at any given point of time, if the availability of cord blood stem cells can help in a miracle cure, then it’s always better to opt in for it.

However, since the internet is also packed with conflicting and dual views about whether or not to opt in for cord blood stem cell transplant, people need assuring stories to get their required dose of encouragement. Here are two miraculous accounts how cord blood transplant from siblings have been able to save lives.

First Success Story

Sun Lexuan, is a five old from China who was chronically unwell with aplastic anaemia. It was when her parents decided to have their second baby, Sun Yiwei, then the infant’s cord blood stem cells were going to be used for Sun Lexuan. Aplastic anaemia is an uncommon disease, that makes the stem cells and bone marrow to stop producing blood cells in sufficient quantity. Sun’s parents were in a fix as they weren’t able to narrow down on a line of treatment that would work effectively. However, they were aware that a sibling’s cord blood stem cell might help.

The umbilical cord is replete with stem cells and is naturally better adaptable than the one’s present in bone marrow. These stem cells are able to miraculously repair the disrupted cells and then produce more white blood cells, platelets and red blood cells. This is the reason why cord blood banking is a secured solution for most parents.

Since Sun’s aplastic anaemia got detected when she was three, her condition got stable with Antilymphocyte Globulin, which is a blood serum that has antibodies. And when her sibling Yiwei was born, that was the moment of happiness for the family. The little one’s cord blood got collected soon after her birth, with the aim for a cord blood transplant to Sun that resulted in the recovery.

Second Success Story

This is the story of a 10-year-old boy from Perth who is one amidst many children to have contributed to a clinical trial test to examine if cord blood stem cell infusions are able to heal cerebral palsy. So, Fletcher Garrett, the boy is all set to participate in Australia’s very first clinical trial. Here cord blood stem cell from a sibling would be used, expecting that it would enhance the motor skills in children affected by cerebral palsy.

This clinical trial would be managed by Murdoch Children’s Research Institute, via the Melbourne’s Royal Children’s Hospital and is also said to be financed by the Cerebral Palsy Alliance Research Foundation along with Cell Care, a private cord blood bank. Since in siblings there’s a likelihood of 25% chance of complete match to the stem cells, few children have qualified to take part in it. The good news was Martha, four-year-old sister of Fletcher was a complete match. This cord blood stem cell transplant took place last year. Fletcher’s mother went ahead with the idea of cord blood transplant as she was positive that it would help her son become fluent in his daily tasks like eating, moving his limbs and also speech and articulation that he had a challenge with. And the results are promising!

Cord blood stem cells have been said to be holding the key to success for regenerative medicine. The success stories around the world stand as a testimony to this fact. So, it’s a smart decision to store the cord blood of your new born so that you can secure the health of your child, siblings and your entire family.

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Presently, the medical world is buzzing with cord blood cell transplant success stories! For its multiple set of benefits, cord blood gets acclaimed as a regenerative medicine which helps to repair tissues and cells. Today, regenerative medicine is considered to be an essential subject in medical science which will have the key to cure irreversible diseases. The umbilical cord blood comprises of a rich source of stem cells that is helpful in this treatment. There are several clinical trials that have been phased to research on the application of cord blood stem cells to chronic ailments and their possible treatments.

The present records state that there are more than 80 diseases that are treatable using cord blood stem cells. It has been shown to treat:

• Cancers
• Metabolic disorders
• Blood related diseases
• Immunological ailments

However, nothing encourages more to the seekers of cord blood cell transplant other than the success stories about fighters of fatal diseases, who combated it all with faith, hope, courage and by selecting the right cord blood bank.

Success Story 1

Erik Haines had been detected with Globoid Cell Leukodystrophy, which is also known as Krabbe disease at the age of 2. This followed when after the sad demise of his brother who was suffering from a similar condition. However, doctors were able to treat this condition with the usage of cord blood stem cells. Erik’s situation wasn’t as critical as his brother, which made the doctors take a call on an early treatment.

Though a cord blood stem cell transplant was the ideal choice for Eric, doctors weren’t able to locate any acceptable donors of bone marrow. During his time cord blood cell transplants was a new medical feat and needed an exact bone marrow match. However, finally the doctors could find a match in a bank in New York and the process was completed. After this Eric was admitted in the University Of Minnesota Hospital for a span of 26 days. After that the doctors declared that he is treated well and his disease had already shown signs of healing in a remarkable way. Erik is leading a healthy and happy life today post the treatment.

Success Story 2

This story is about Anthony Dones, who got diagnosed with osteoporosis, when he was at a tender age of 4, which made his bones brittle and caused them to break. To heal this issue when he was just a baby cord blood stem cell therapy was the only medically viable choice. His doctors went ahead with the treatment process first by searching at the cord blood banks to search for a matching donor.

As a couple of weeks passed by, the doctors chanced upon a suitable match and then Anthony got hospitalized back in December 2002. For 8 days he was given chemotherapy to minimize the percentage of harmful body cells. Post that the transplant took place. Anthony after the transplant had to stay in the hospital for close to 2 months. Next year 2003, during the last half of January Anthony’s blood cell levels got completely stabilized and he was then discharged from the hospital.

Today, Anthony is leading a normal life happily with this family and his family. The best part is Anthony’s family had stored his cord blood with a private bank during his birth. However, the cord blood cell that was donated when his transplant was taking place was more efficient. However, Anthony’s family also came up with the decision to have his stored cord blood donated to a clinical research team that is studying the impact of stem cells on osteoporosis.

All these success stories about courageous individuals who decided to fight their ailment with cord blood transplant gives hope and also the motivation to opt in for cord blood banking and donation.

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With CRISPR technology editing the DNA code of human embryo, can we hold our breath for an absolute eradication of inherited disorders like Thalassemia and similar conditions? The answer is still unclear as there is no such publication about the claims on decoding the DNA with CRISP editing technology. As per the MIT Technology Review, the research team led by Shoukhrat Mitalipov at Oregon Health and Science University has been successful in an effort to edit the genes of human embryo using CRISPR editing technology for the first time.

Gene editing has been a controversial practice, but still we had earlier seen three such efforts involving human embryo editing in China.

You can call it genetically modified human embryos or improved embryos sans defective cells with mutations responsible for inherited diseases. Even if DNA editing is controversial, it contributes to the elimination of hereditary illnesses.

Advantages of CRISPR Editing Technology

The genetic manipulation using the CRISPR editing technology in the human embryos seems viable and an effective way to remove defects from the genes, and combat thousands of diseases. The technology uses molecular scissors to influence the performance of the gene sequencing. And as a result, it can eliminate the undesirable components from it. Hence, it paves the way for the replacement of new and improved DNA with the faulty genes.

The claim also raises hopes for families with concerns for the genetic diseases, as it is capable of preventing the further spread of the deadly disorders like malaria in the body.

There is another way for which the finding holds a true and promising possibility for our future generation as well. By editing the gene sequencing in the human embryos, we can expect the “human germline editing”. This means when the editing technology will instill embryos of offspring with new mutated cells, the characteristics and features of the edited DNAs will be carried through offspring after offspring. So, the germline gets fixed permanently in each successive generation and follows a hereditary pattern of a family.

With the new CRISPR editing technology, we have no more editing errors known as “mosaicism” as was the case with earlier Chinese experiments. And the desired improvement technique is thought to be followed not only by some, but all the cells in the embryo.

Contradictory Opinion About The Claims

Some critics argue that we absolutely do not need such technology to detect deformities in human embryos and correct them with CRISPR editing technology. That’s because the efficacy of the technology is deemed unfit as it is unable to perform as expected if two copies of defective genes are present in the embryos.

On the other hand, we already have preimplantation diagnosis technology or OPD to detect disease causing cells in the embryos. And by using this technique, the faulty genes can be replaced through in vitro fertilization.

Disadvantages

The techniques seem to violate the rule of natures as it advocates for the creation of the designer babies. Rather than editing the disease causing genes, the technique is more likely to foster the enhancement techniques, meaning future parents would seek editing techniques to remove imperfections in their children. And we fear that this approach would lead to a genetic discrimination.

However, if the claims are true, we can free ourselves from a range of diseases, including anemia, Huntington’s disease and other genetic diseases through gene modifications. So, let’s keep our fingers crossed for a true future possibility.

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Children are like clay. At the young tender age, they tend to mould themselves based on their interaction with the world around them, just as a lump of clay does.

The development that takes place in a child while growing is impacted to a large extent by the interactions that happen with him/her. This is the reason why young pups or kittens seem to be very playful at this tender age. Obvious reason is that everything around them is new and exciting and they want to touch, feel, taste and see.

In humans, it is absolutely important for a child to have interactions with other humans of different ages. Not that less interaction causes a problem, but the more they play, the more they understand. Their brain starts to register impulses and creates appropriate response.

Play time also helps in developing their social and emotional competence, physical development and creative development. Here’s how,

Social Competence

During play time, a child gets to communicate in both verbal and non-verbal ways, trying to understand what is expected from him/her when his peers or adults talk to them or signal them for an action.

Play time is crucial for a child to develop and express feelings, like laughter, anger, sadness which play an important role in their overall behavioural growth.

The understanding of being good or bad in comparison to older children, comes from being engaged in spontaneous or structured play activities. These opportunities to monitor and discriminate among feelings and emotions contribute to children’s beliefs about their own capacity.

Physical Development

Development of fine and gross motor skills in conjunction with body awareness in children is a direct contribution of play. By learning to use writing tools, it initiates the development of fine motor skills in children. However, the development of gross motor skills happens in a completely different manner. By practising to hop on different feet is a significant start of this development in children.

Children feel more physically confident, safe, and well-balanced when they use their bodies during play.

Creative Development

In order to initiate the process of creative development in a child, play-time performs a crucial role where the child feels secure in the environment of a playgroup. They feel free to create a world of their own in which they get the freedom to decide the interactions that they want to have and rearrange the things in a way that they see fit, hence encouraging them to use their creativity in a group environment.

‘Play’ and its role, is as deep-rooted as it can be in a child’s life Albeit, as children grow older and become mature, the significance of ‘play’ also undergoes changes that ultimately bears a strong presence in their development as emotionally, physically and mentally strong individuals.

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Did you know why stem cells grow into different cell types and can transform into any cell type in our body? The secret lies in the capacity stem cells, which bring about a unique regeneration of tissues or cells in our body.

These unique properties of the stem cells are due to the pluripotent cells that command the stem cells to execute the cell differentiation process.

And through a regeneration therapy, pluripotent stem cells contribute to the development of many treatment options for us.

How Pluripotent Stem Cells Help to Develop Treatments and Therapies for Various Diseases?

It is in their nature to grow into any cell type or tissue in our body to counter attack the occurrences of a wide range of disorders. A range of diseases includes from blood glucose disorder, to spinal cord injury to heart disease to childhood leukemia.

The stem cell’s pluripotency has the potential to be reprogrammed as any genetic match for us. And it makes it feasible for us to go for any transplant without any need of matching donor cells, or the difficulties of tissue rejections. At the same time, the pluripotency reduces the use of immune-suppressing drugs post the transplant.

Another way, pluripotent stem cells can be used as a great laboratory work to study the etiology and ways to treat disease in cells. They are a great source of tracing the early signs of disease- causing effects of premature aging, cancer, and heart disease.

What Makes Pluripotent Cells to Act This Way?

A team from the University of Zurich discovered an answer to this unique characteristic of pluripotent cells. A comprehensive description about its nature and character is detailed in a publication called Nature Cell Biology.

It is discovered that during the development stage, our stem cells grow as embryonic cells. This embryo consists of a protein known as Pramel7. The presence of this protein in the embryo cell ensures that cell’s DNA does not develop any epigenetic scars, which are essential compounds to command genes to go on/off by working as an eraser.

Being a blank cell, the genomes of embryonic cells do not encompass any traces of epigenetic marks, and hence they are programmed to follow any developmental path to transform them into any cell in the human body. However, as time progresses, embryonic stem cells could turn into matured and specialized stem cells, and during the developmental phase, epigenetic marks known as methyl groups get capped to the genomes. This process occurs to influence the performance of genetic materials not necessary for the growth of the cells.

The further discovery of protein Pramel7 by the scientists emphasized on their special characteristic of activation in the embryo cells. The proteins could be active in the embryonic cells for about a few days. However, outside the embryo cells, when they were grown in the culture dish, they had no signs of Primal7 proteins, and their cells were found to have more methyl marks or epigenetic marks.

The protein Pramel7 could have less activation period, but the short span of time is enough for performing a great job for the cell development in the body. So, with the new discovery of the stem cell pluripotency, it is able to address a series of health issues by using regenerative therapy.

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The human body is an intriguing structure with numerous connective tissues and cells all throughout our body. Cells and tissues are connected with each other to trigger specialized commands that are essential to carry out physical functions. On failure of any of the cells and tissues, it activates the foreign intruders to assail our physical build and put us to risk of a range of diseases.

Nonetheless, the immune system in the body is responsible to contribute to the disease combating capabilities to us so as that we remain immune to the prevalence of the serious illness and infectious diseases. The components of the immune system or immune cells have the potential to fight foreign invaders and also against antigens.

The Key Component of Immune Cells

White blood cells or leucocytes/leukocytes are the key components of the immune system or immune cells. All types of cellular elements of blood including red blood cells, white blood cells and others originate from the same progenitor or hematopoietic stem cells in the bone marrow. The pluripotent cells in the HSC give rise to leukocytes. Our immune system receives immune responses from the white blood cells, while the differentiation of mast cells in the myeloid lineage (the birth place of leucocytes too) causes inflammation and other physiological and pathological conditions in our body.

Conditions Caused by Mast Cells

In the presence of stem cell growth factors and other cytokines, mast cells circulate everywhere in the body. When rested at normal conditions, it regulates a series of conditions such as vasodilations and adaptive immune responses. However, we can hold mast cells responsible for many health problems like asthma, allergy, gastrointestinal disorders, different types of leukemia and also heart related diseases.

So, the formation of immune cells is considered to pave way for different medication and treatment options to treat the conditions triggered by mast cells in the body.

A New Concept About the Development of Immune Cells

Mast cells or the key component of immune cells- leucocytes are originated when triggered by the stem cell growth factors. But, the scientists at the Karolinska Institute and Uppsala University, emphasized on another source for the formation of immune cells including mast cells and blood cells. The new discovery is promising for the development of new research works and new medicines and therapy for a curative treatment of immunodeficiency disorders.

Study Validating the Effective Application of Mast Cells

The key specimen for the study was uncommon mast cell progenitors collected from the blood, and they were cultured in the lab. The cells were allowed to differentiate and mature under the factor interleukin 3 and 6, instead of the stem cell growth factors. The research showed the cells were able to develop normally, and no influences of stem cell factors were needed.

The administration of imatinib (Glivec) on the patients also showed an anticipating result, which validated that, the progenitor cells remained unchanged, while the mast cells got reduced in numbers under the influence of these drugs. The drugs also prevented the stem cell factor from unleashing any impact on the mast cells in the patients.

So, it is clear from the study that mast cells do not need stem cell growth factors to develop, and this revelation could help researchers to create new medications for hematological disorders, which are unresponsive to the application of imatinib (Glivec). Instead, we can take a cue from interleukin 3 factor (friendly atmosphere for mast cell development) could hold possibility for the development of new treatments and medications for hematological disorders.

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Everybody poops. But babies have a special power, I guess. Well, that’s the only thing that they can do, apart from eating of course, and we all did the same when we were babies too.

I’m Aryan, a young father and a complete novice when it comes to handling babies. I was super thrilled when my daughter Asmi was born. I took her in my arms and she was the size of a soccer ball. I couldn’t believe that Sanya (my wife) and I created such a beautiful thing!

A couple of months passed, waking up in the middle of the night, sleeping during the day, eating scraps at home became a routine (well, when you have a baby, forget about a lavish spread for a meal at home). As well as Sanya was handling being a mother, I was barely able to manage getting around my duties as a father. And the deadliest of them was the diaper change. I heard and saw a lot of tales of dads failing miserably in diaper change but never thought it would be so disastrous for me. Here’s the horror story – 10:30 am on a Tuesday morning. Sanya was busy on her laptop in the study (yeah, awesome of her boss to allow her to work from home till Asmi was about a year old). She was preparing to give a product demo to a prospective client and I knew that it was time for me to step in as the nanny. Asmi usually wakes up at 10:30 am. So I was pacing along the bedroom waiting to hear her cry as she wakes up. Bingo! Asmi did not cry, she screamed…And I was shaking as though I had seen a ghost.

I quickly went to her crib to pick her up and suddenly, my nose exploded! The stench was brutal. It could kill a rodent in a jiffy!! I put her on the bed and against all odds (my inner voice screaming to run) pulled her diaper out. The massacre was unbelievable. Poop all over. I had never seen so much poop in my life! I quickly disposed the dirty diaper, cleaned Asmi (all the time thinking that it will be over soon) and was about to put a fresh diaper, that I heard a sound, it was faint in the beginning but then the volcano erupted (this time a fart, and a really nasty one). All this while Asmi was in a jumpy mood, but the fart changed everything! She suddenly started laughing!! Oh My God, she looked like an angel!! I changed her clothes, gave her a bath and kept her breakfast ready (in my mind I knew that I have to encounter another ordeal in a couple of hours).

Being a parent is not easy. It takes everything you have to care for a baby but that one look at your baby’s face makes you forget every sleepless night, diaper disaster and tantrum that you go through.

What’s your diaper failure story?

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Expert doctors in Sheffield, UK have confirmed that MS (multiple sclerosis) patients have witnessed phenomenal health improvements opting in for a treatment, that’s generally used for cancer. Approximately, 20 MS patients recently have said yes to bone marrow transplants resorting to their own stem cells. And few patients were completely paralyzed and showing zero chances of being able to walk.

According to Prof Basil Sharrack, Royal Hallamshire Hospital, Sheffield the fact that there’s a treatment available for MS which can heal the disability completely, is a stellar achievement in medical science. Today close to 100,000 UK inhabitants has MS, a chronic neurological condition, that’s incurable. Most of these patients generally get detected with this ailment in their 20’s or 30’s. A person having MS will have his/her immune system to attack the nerve lining of the spinal cord and the brain.

Multiple Sclerosis Explained

When a person is affected by MS his/her protective cover encompassing the nerve fibres of the spinal cord and the brain, called the myelin gets damaged. The myelin gets attacked by the immune system, resulting in sclerosis or scarring. The disrupted myelin further damages the nerve signals. When this scarring and inflammation is not halted, then the person suffers from permanent neurodegeneration.

MS Stem Cell Trial in Hospitals of UK

Recently there has been advanced clinical trials happening in UK hospitals like Royal Hallamshire Hospital, King’s College Hospital and many others, that has resulted in phenomenal outcome. The example of Holly Drewry, 25 living in Sheffield who has taken part in these trials is noteworthy. After she gave birth to her daughter Isla, her condition worsened making her stagnant in a wheelchair. She shared with BBC’s Panorama that she wasn’t able to walk straight and was scared to even hold her daughter, lest the baby falls. And with every passing day her MS condition was deteriorating.

It was in Sheffield that Holly got her MS cord blood stem cell treatment and results were miraculous. She witnessed positive improvements in her condition within a couple of days of the transplant. She was able to walk. And when she was treated completely she went back home, hugged her daughter being completely overwhelmed. This is nothing short of a miracle for Holly.

An in-depth analysis of the treatment that was given to Holly revealed that her paralysis has been cured to a great extent. Though she has to be under medication and medical guidance in the years to come, but the cord blood stem cell treatment has taken her out of the zone of paralysis, which is a complete blessing. Surprisingly, Holly isn’t the one today who’s been cured of MS paralysis. Apparently, Steven Storey, eminent marathon runner and tri-athlete too suffered from MS paralysis and he couldn’t even flicker a muscle. Post his stem cell treatment Storey was able to move his toe in about 9 days and gradually recovered back to normalcy.

The Treatment – A complete Reboot of the Immune System

The medical treatment that has been healing MS paralysis is known as HSCT, which is an autologous haematopoietic stem cell transplant that completely destroys the non-functional immune system through chemotherapy.
Post this, the immune system gets re-created using the stem cells sourced from the patient’s own cord blood. These cells are nascent and don’t have the trace of any flaws or irregularities. Prof John Snowden, Consultant Haematologist, Royal Hallamshire Hospital reveals that the immune system gets completely rebooted back to a state, when there was no MS.

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Mindfulness is paying attention to the purpose and accepting the present moment. Therefore, mindfulness during childbirth is a preparation to develop a relationship with yourself, with your partner and with your family.

According to a recent study, mindfulness can help the pregnant woman to overcome delivery anxiety and maintain a sense of calm. It also reduces the postpartum distress and creates a feeling to accept the pain and give childbirth happily.

Useful tips for mindfulness during childbirth

• Meditation: Meditation can help to relax both mother and baby on the deeper level. When you practice meditation regularly, you will make yourself and your baby to learn not to react to the stressful situations and avoid depression. In other words, meditation helps to regulate blood pressure, removes the risk of preeclampsia, miscarriage, placental breaking. Meditation helps the baby to have a sound sleep, prevent allergies, improves the baby’s growth, boosts breastmilk and removes the production of stress hormones.
• Increase Your Awareness: Encourage yourself to prepare for childbirth. Attend childbirth and breastfeeding session with your partner and talk with your doctor about what to expect so you can aware of your pregnancy complications. Choose a good doctor and build a positive relationship to trust them during childbirth and keep calm dealing with stressful situations. This mindfulness helps you to become aware of several labour outcomes.
• Relax: Let your body relax not only from outside but also have mindfulness that keeps you emotionally healthy. Try to take rest often, get enough sleep, try changing your exercise schedule and feel your baby. Relaxing will help you with the risk of preterm contractions that also improves your health.
• Comfort your pain: Childbirth pain is not only in your body, but it’s in your mind too. When you accept this pain in your mind, you will feel that this pain is necessary to bring your baby into this world and the pain will be tolerable.
• Don’t Make Childbirth Plan: Do not predict childbirth as every woman has a different delivery. We cannot plan a fixed time for labour, how the baby can tolerate the pain or how your contractions will work. Therefore, have mindfulness and make a simple wishlist that may come in handy at the time of decision-making.
• Keep yourself physically active: Regular exercise according to your pregnancy health can help you stay energetic, reduce your body pain, back pain, increase blood circulation, and prevent you from getting stressed out.
• Create a good environment: Keep a calm and happy environment which helps the pregnant mother to feel good. This relaxed mindfulness helps to release a hormone (oxytocin) for relieving the childbirth. Try to keep everything as much as you feel safe, secure and comfortable. Choose a positive family member whom you can trust.
• Save yourself from getting tired: You may not have the exact things you thought will happen until childbirth. Mindfulness can help you understand the continuing process of your body. Even if you have a 10-centimetre dilation then also you have to wait for the baby to come into the birth canal and you feel the urge to push the baby. If you force it, there are chances to get exhausted soon.
• Let your partner know that you need them: Affection and support of the partner are most important for a pregnant woman during childbirth. Therefore, it is recommended for every significant other to be with their wife. It is that remarkable time in your lives to make your bond stronger with your partner and baby. The more you make them feel you are there, it will help a pregnant mother to have relaxed delivery.

Practice the above mindfulness ways during childbirth and bring the gifted life into the world, happily.

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Having my little princess was a prayer answered! The moment my pregnancy report was affirmative, I leapt in joy, almost envisioning the moment when I will be cuddling my newborn and start parenting, which I had been anticipating for a while now. Today, after undergoing a C-section and having my baby, I indeed have all that I asked for but there’s also an impending gloom and mild despondency that is smeared all over my mind. The truth is, I loved all that my pregnancy got me, but not this postpartum body. Other than my immediate weight gain which I anticipated, I have to accept the fact that my body nowhere feels close to what it used to pre-pregnancy. That’s a complete disappointment!

The constant fatigue, my expanding and shapeless mid-riff and increased weight is what I want to skip, instantly. Additionally, I have a weak core and have to smile through pains and aches at times that could be an after-effect of stress. Trying to keep myself motivated constantly, a thought that often races my mind, is “how to get back to shape?”

Subconsciously, I am aware that daily exercise or a brisk morning walk has my solution! But recently other than energy what I also lack are discipline and determination. Add “me time” to it! My life is centred around my baby girl. So there have been moments when I had set the alarm for a walk or a mild exercise session, but inactivity has got me in its snare. That aside, the unhappy part of me wants immediate results to which my wiser practical self says, ‘Relax, give it sometime’! To which I oscillate back to an old mind recorder that plays in loops for hours stating and asking, whether I will ever get back to the shape that I was in love with. With the wide a belly pouch and a wide hip bone it’s tough to avert the worry.

“Embrace yourself and your body” is what my best friend told me the other day over a conversation!

That seemed to have been brought some light to my otherwise low self esteem resulting from my postpartum body. “If you don’t love your body for what it is albeit the post pregnancy flab, shape and stretch marks, then you would be passing the same notion of being perfect body wise to your daughter. Whilst that would give her necessary teachings about fitness but it would make her excessively conscious about her body! She will start looking at it as her only source of happiness” assured my friend.

And perhaps on hindsight, that’s exactly what I have been doing! Making the source of my happiness to the question, “When do I get back to shape”! I felt lot easier and realised that after all, my body change was natural and with regular exercise and a new diet I would be back to shape. This perspective was an instant mood enhancer.

As I started to chart down a new diet and exercise regime my mind happily settled to yet another realization! Comparison. Yes, I have been comparing myself with other women I know and their postpartum bodies. Some of them have bounced back to shape fast and for the rest, motherhood was the only focus. I realised pregnancy and its body changes are unique for every woman. So, whilst setting new health goals for myself I got committed to halt this constant mind-comparison chatter.

And today, as I have set out on a new journey as a mother, to get back to fitness I say it’s all about coming to balance within, based on where you are, where you want to go and how best you make utilize your resources available!

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Morning sickness is one of the signs of early pregnancy. Normally, morning sickness occurs around the 4th week of early pregnancy and gets resolved between the 12th and 14th week. In some cases, 1 in 5 women, suffer from morning sickness throughout their second trimester. Some pregnant woman, experience morning sickness throughout the whole pregnancy period.

If you have travel motion sickness, then you are more likely to experience morning sickness.

Unrelieved morning sickness can disturb your quality of lifestyle by stopping you from working, socializing or taking care of other family members.

During morning sickness pregnant women suffer from psychological problems such as mood swings, anxiety, stress and depression. They experience quick changes in their behaviour like anger to happiness or sadness. False myths are making the rounds that morning sickness is psychosomatic, which means that it is a physical illness caused by internal metal conflicts. Though there are, no research to confirm these beliefs.

Possible Causes of Motion Sickness During Pregnancy

• Motion sickness occurs when you travel by car, aeroplane, boat or bus and the body’s sensing system sends conflicting signals to the brain through eyes, ears, mussels and sensing nerves.
• If you travel quickly after having full stomach meal then, constant up and down, it disturbs the digestion system and causes motion sickness.
• While travelling, you have to deal with a lot of air and that makes it difficult to breathe which may make you nauseous.
• Increasing levels of hormones.

Signs of Motion Sickness During Pregnancy

Nausea and vomiting are the signs of motion sickness. Apart from that, you may experience few more signs such as:

Dehydration

Extreme morning sickness can harm both mother and baby’s health because of the loss of fluids and stomach acid that happens during vomiting which causes electrolyte imbalances.

Discomfort

Severe vomiting, multiple times causes a pregnant women to feel discomforting pelvic pain and stomach pain.

A Headache

Low blood sugar and hunger prompts a headache. Often pregnant women are likely to feel a sharp pain or a constant dull ache on both sides or the back of the head. If one experiences tension headaches, then pregnancy can make it even worse.

Fatigue

In the early days of pregnancy, pregnant women may feel extreme tiredness occurring from mental or physical exertion.

Dizziness

In 5 to 6 weeks of pregnancy, the body expands the blood vessels and relaxes, because of hormonal changes. These conditions increase the blood flow to the baby, but reduces blood pressure that may make pregnant women extremely tired and weak.

How to Manage Morning Sickness?

One can talk to doctor as every pregnancy is different, but can follow few steps such as:

• Breathe fresh air and avoid the cooking smell, any room freshener and fragrance which can triggers nausea.
• Ask the doctor before taking any medicine.
• Eat small meals or snacks for good digestion.
• Drink enough water, to be hydrated.
• Take vitamin B6 supplement lesser than 200 mg by consulting the doctor.
• Wear comfortable clothes, avoid tight cloth around abdomen.
• Rest as much as possible.

Remember to seek medical help if the morning sickness and motion sickness get severe and if one sees quick weight loss or is feeling stressed all the time. You can still relieve from morning sickness.

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Restless legs syndrome is a neurological disorder, which affects the sensorimotor of the body. The physiological process of the disorder is still unclear, but the prevalence of the disorder is high amongst the patients depending on their primary and secondary etiological conditions.

Genetic issue is the primary reason for the patients developing this disorder, while the idiopathic or secondary restless leg syndrome becomes prevalent with the kidney disease or peripheral nerve issues. However, the most common condition and prevalence of RLS is highly associated with the patients in their pregnancy. And RLS during pregnancy is experienced by two to three times more individuals worldwide than the normal population, and most likely influenced by which trimester the pregnancy is in along with the number of parity.

What is Restless Leg Syndrome or RLS?

A frequent urge to move the legs because of the unpleasing sensations in the sensorimotor leg nerves is called Restless Leg Syndrome or Willis-Ekbom disease (WED). The disorder becomes more acute due to an impact on the neurological parts of the body.

The pain of the disorder starts showing its influence while at rest, and the symptoms subside with the constant movement of the legs. However, the symptoms become worse in the evening and interfere with sleep.

As per the study published in the Journal of Midwifery and Women’s Health, 26 per cent of pregnant women are developing RLS. When it occurs to pregnant women, it feels like a burning, creepy, crawly and pulling sensation in the legs, which advocates for the constant movements of the affected legs. The relief comes with it, but, by then your sleep is gone.

Reasons for The Occurrence of Restless Leg Syndrome during Pregnancy

The exact reason behind the aetiology of RLS in women during their pregnancy is still obscure. The scientists fail to offer an exact explanation for the sensations caused in the legs at night. However, the hormonal imbalance of dopamine in the brain may trigger the symptoms of RLS in pregnancy. This is the chemical responsible, which intensifying bones and muscles and keeps muscle movements in check. Other than this, an excessive excretion of estrogen during pregnancy results in RLS, coupled by a deficiency in iron and folic acid.

So, while the condition is so irritating, you try to ease it. But it leaves you making sleepy and irritable during the day.

How to Find Relief From Restless Leg Syndrome During Pregnancy

If you think your conditions or symptoms are quite severe, you need an immediate clinical intervention. Your doctor may help you out of the problem. Your doctor may suggest you some medications. Or before you take any medications; your physician may advise you to take iron supplements if you lack iron. An iron supplement is enough to cure your RLS.

If your condition is still severe, it may lead you to go for a C-section as the labour increases with the symptoms.

When the Condition is Not That Worrying; Some Easy Changes to Your Lifestyle Routine May Help

• Making adjustments to your sleeping position may help. Avoid sleeping on your front or your back. Sleep on your left side. This sleeping pattern improves your blood circulation and gives you additional support.
• Develop a good sleeping routine. Go to sleep at the same time at night.
• Improving some of your drinking habits eases the symptoms. Do not take aerated drinks, coffee and soda.
• Exercise daily. Don’t stretch it too much before your bedtime.
• Give your legs a good massage. You can also get a cold and warm compress for your leg muscles.

These comfort your symptoms at night. Try this. However, the symptoms of RLS disappear once you give birth. So, this is good news for you.

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Pregnancy is an amazing time in a woman’s life to experience wonderful changes in the body and to experience your baby growing inside you. Sadly, some hormonal changes during pregnancy can affect your digestive system and cause annoying discomforts.
So, want to know how pregnancy creates digestive and gastrointestinal problems?

Nausea

During pregnancy, 90% of women experience nausea. Some women struggle with severe nausea called hyperemesis gravidarum (HG), which is caused by the abnormal blood pressure in hormones. Unlike normal pregnancy, severe nausea will not stop in the 14th week that creates dehydration. This condition requires medical treatment.

Constipation

Constipation is a common condition in pregnancy. It occurs because of progesterone; a hormone produces by the ovary to regulate multiple functions and relaxes muscles in the body. Increased levels of progesterone cause the food to move slowly in the intestine that may lead to constipation.

According to evolutionary perception, developing additional progesterone helps to relax the uterus to prevent premature labour.

Another reason for constipation during pregnancy is because of the extra intake of iron which is present in the prescribed supplements by the healthcare provider, that causes dry stools which can be hard to pass.

Heartburn

Heartburn is a feeling of burning sensation in your chest caused by stomach acid reflux. When progesterone relaxes the muscles, the stomach muscles at that instance forces the digestive acid upward into the esophagus (a muscular pipe connecting stomach to throat).

Do not misunderstand, that you are producing extra acid. Heartburn is just a condition during pregnancy. If you take anti-acidic medication, then it will reduce digestive nutrient acclimatization.

Flatulence (Gas Problem)

While progesterone relaxes the body muscles in the gastrointestinal tract, food moves slowly and cause the gas to build up quickly. It will be very discomforting for you as your uterus feels pressed down on the rectum. Therefore, try to release this gas as much as possible.

Reduce digestion troubles during pregnancy

• Drink plenty of water. More liquid makes a soft stool that passes easily through the intestine.
• Eat more fibre such as vegetables, whole grains, and fruits, legumes to speed up your metabolism and keep the stools soft.
• Keep yourself active. Do exercise regularly for at least 20 minutes a day. If you cannot do any specific exercise, then you can just do walking for 15 minutes, several times a day at regular intervals. Walking stimulates bowel movements and regulates the digestive tract.
• Avoid stress because it will make your metabolism slow and create a digestion problem. To keep yourself healthy and stress-free, try various stress management techniques.
• Cut down on fatty foods. Eating more fat can make you more constipated. But still, your body needs good fats, such as avocado, coconut oil, olive oil and nuts.
• Avoid sugary food: Reduce intake of carbohydrates during pregnancy. More sugar can slow down the digestive system and cause constipation. Eat more green vegetables and protein.
• Scheduling eating time can help the digestive system. Eating a small meal can reduce the digestible time and speed up your metabolism. A small meal gets digested and makes space for the next meal. Therefore, plan your eating habits.
• Avoid smoking and alcohol consumption as it directly impacts on the baby’s mental and physical health. Smoking during pregnancy can disturb your digestive system and lead to ulcer and infections. Alternatively, drink enough water.
• During pregnancy maintain your morning schedule for the restroom. Try using the squat position to get your stomach free easily. While you are in the restroom, maintain your posture, such as stand straight, sit with your back. A good routine will help the digestive system.

Get advice from your doctor before taking a laxative, as an overdose of laxative can harm your baby. A healthy habit is essential for both the mother and baby’s health. Try out the above tips to help your digestive troubles and maintain healthy pregnancy.

Sources:
https://www.familyeducation.com/pregnancy/digestive-problems/digestive-problems-during-pregnancy
https://balancedbites.com/troubleshooting-your-digestive-issues-tips-for-common-digestive-issues-in-pregnancy-part-4/
https://www.nhs.uk/conditions/pregnancy-and-baby/severe-vomiting-in-pregnancy-hyperemesis-gravidarum/

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As a pregnant lady, you and your partner have to make couple of important decisions, other than thinking about how to raise your little one. Having thoughts on giving your child a healthy food regime and following the best parenting practice must be hovering on your mind. But here’s where you need to make some space to address the question – Should you opt in for cord blood banking? And what’s the best option for you?

The ultimate objective of any parent is to do everything at the best of their capacity to ensure that their child never witnesses a health crisis. And as most doctors and medical researchers have already claimed, that one of the ways of securing a child’s future is by opting in for umbilical cord blood banking. The cord blood stem cells are potent in curing diseases that have been said to be irreversible. So today, there are primarily two groups of parents – one who privately bank their child’s cord blood privately and the others who donate the same to a public bank. And if you are in India and want to select between private or public cord blood banking, here’s what you need to know.

Public cord blood banking challenges

Given the Indian scenario, the acute challenge in the field of public cord blood banking is locating and then storing sample blood units that would match the population and ethnic diversity of the country. Hence, when there’s a need it might appear to be very tough to come across a donor that would be the best match for a child or an adult who needs to do a cord blood cell transplant to overcome a fatal disease. This was the situation of Dr. Nalini Ambady, who was an Indian American professor who couldn’t survive as she didn’t have access to a correct stem cell match.

Not every sample in feasible

Matters related to public cord blood banking get further complicated by the collected sample quality. There are situations when most samples have to be cancelled owing to the insufficiency of stem cells. Sometimes parents are not made aware of the fact that every sample might not be used. Also, parents should be made aware, that just by storing cord blood doesn’t mean parents have locked the “treatment” for their child, siblings, family members or even themselves. So, when parents show interest in public cord blood banking these aspects should be addressed to provide a practical perspective.

Private cord blood banking

With private cord blood banking parents have the scope to store their child’s cord blood for their own use or be used by a family member. In simple words, the family has complete “ownership” of the cord blood unit and has the power to arrive at making important decisions on how to use it. However, what seems to be a challenge here is the cost of private cord blood banking. The initial collection and the annual storage charges is an expensive amount. But the aspect of ownership is what makes most parents say yes to private cord blood banking.

Considering the expense that one has to incur, often parents-to be are caught into endless thought loops on what could be the best choice of cord blood banking. According to the, American Academy of Paediatrics (AAP), a family must consider private cord blood banking as the baby’s cord blood stem cell might turn out to be a better match for any sick member of the family, as compared to a non-family donor.

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We all seem to be aware of the deadly effects of leukemia, especially in infants. The prevalence of the disease interferes with every sphere of our daily lives and activities. A combination of chemotherapy and stem cell transplant can find us relief though; they expose us to minor to severe side effects, including graft-versus-host-disease (GVHD), coupled with some complaints of toxicities as well. However, a recent research from Fred Hutchinson Cancer Research Center had confirmed that treatment with umbilical cord blood transplant offers a better survival outcome, without any need of a traditional donor match. So, all the leukemia patients need not to queue in the line for years to find a matched donor for their stem cell transplants.

Nor does the umbilical cord blood treatment offer better curative possibilities for patients with leukemia; it alleviates the chronic conditions associated with Myelodysplastic syndrome and other bone marrow disorders as well.

How Cord Blood Treatment Raises Hopes for Us Suffering from Leukemia
A study published in the New England Journal of Medicine by the Fred Hutchinson Cancer Research Center highlighted the benefits of cord blood treatments. And it is established that in patients with “minimal residual disorder” could not benefit from the transplant as the chemotherapy does not put cancer cells into remission, while patients with detectable cancer could remain alive for three years after the transplant.

The research focused on the successful treatment options of the cord blood therapy, which improved the conditions of patients with detectable cancer cells, with less traces of relapse complexities.

Conversely, patients with minimal residual disorder who underwent the transplant using adult and unmatched donor cells faced very poor outcomes.

For bone marrow cell transplant, patients with matching donor can receive a higher chance of transplant. At the same time, transplants with mismatched donor cells could be effective, but they do not occur more often. However, the cord blood transplant does not advocate for a matched donor for the successful treatment or transplant.

Hence, you are more likely to receive a range of great advantages from a cord blood transplant as opposed to bone marrow stem cells.
Every one of us has a greater access to the cord blood donors. And that’s the reason why cord blood transplant can be made available to more populations as compared to the adult or allogeneic stem cells.

Adult stem cells work in sync with Human Leukocyte Antigen or HLA genes in our body to confirm the likelihood of acceptance or rejection of donor stem cells. Since, umbilical cord blood cells are not as developed or matured as adult stem cells, they do not require following the unique genetic background rules to match HLA. And hence, the doctors and clinicians can collect cord blood cells quicker and can initiate the treatment faster than stem cell therapies.

The transplant using cord blood is less likely to be dependent on the matched donor, while the mismatched donor is accepted and effective for the curative treatment of this deadly disease.

And hence, an easier accessibility and availability ensures that none of us will remain deprived of the better cancer treatment options, and receive a successful transplant every time.

So, the effective treatment possibilities with cord blood cannot be regarded as an alternative donor. In another way, if you have chances of developing the relapse risks, cord blood transplant is the safest and best choice for you.

Sources:
https://www.cordbloodbanking.com/cord-blood/treatments/leukemia/
https://www.webmd.com/cancer/lymphoma/news/20160907/cord-blood-transplants-show-promise-in-leukemia-treatment#1

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The brain and spinal cord are integral parts of the neural tube, which develop from the embryonic cells. During the formation of the neural tube, the morphogen gradients situated in the anti-parallel position regulate the development of the system. When the cells of the neural tube mature with a variety of cells, they lie in a pattern of Dorsal-Ventral. The design and the texture of the Dorsal-Ventral Pattern are different from individual to individual. However, it’s morphogen gradients, which decide the position of each cell in a living organism through the pattern formation. The morphogens are able to provide apt information about the neural tube at the top their gradients. But, they are incapable of providing the exact information about the neural tube in the middle.

The Functions of Morphogen

Morphogens develop a graded distribution; instill cells with appropriate cellular responses. The substance can comprise intracellular factors, and also extracellular factors. It is responsible in determining the location or position of an individual cell.

How Morphogen Gradients Influence the Pattern Formation of the Neural Tube

Two proteins such as Sonic Hedgehog (Shh) and Bone Morphogenetic proteins (BMP) develop anti parallel Morphogen gradient and the Dorsal-Ventral axis. And therefore, both the substances are responsive to the protein signaling from Shh and BMP. Whereas positional information is concerned, the apt and accurate information is largely dependent on the antiparllel gradients of the morphogen as opposed to the single gradient. And the antiparallel morphogen gradient cannot function solely without the integration of the protein duo such as Shh and BMP.

Validating the Truth of Pattern Formation of the Neural Tube

Shh and BMP work as precursors to establish the pattern formation in the neural tube in the vertebrae. To validate the statement, a study has been conducted in the neural tube of a developing mouse. A compound is used to measure the Shh and BMP signaling features. The phosphorylated Smad1/5/8 is assumed as BMP signaling data, while Shh signaling gets transcriptional reporter identification

During the first 30h of the formation of the neural tube, the levels of two of the proteins remained unchanged from the distance of its source. However, a little later, the gradients became contracted. This emphasized that two signaling proteins stayed in their greatest distance during the formation phase at the earliest. Later on, the distances between the gradients shrink with the increase in size of the tissues.

The Key functions of the Signaling Gradients

In order to provide precise information about the positional identities of the neural tube along the axis of the Dorsal-Ventral, the signal gradients must compose of accurate positional data.

With the positional error, when one cell is closer to the morphogen source, the proteins are incapable of offering accurate positional information of the neural tube throughout the DV axis. But, after 30h the levels of the proteins decreased in the middle of the Dorsal-Ventral axis. The positional error increases when the proteins remain less than 20 cell diameter from the morphogen source. However, when both the proteins remain at more than 3 cells diameter at 5h around the DV axis much before their development stage, they offer the correct location wise information.

Gene Regulatory Networks

Another way to decide the positional pattern of the neural tube is gene regulatory transcriptional networks. They are the most reliable technique to have a clear understanding of the positional information of the neural tube. In the growing mice, these networks collect information from the disputing gradients for neural progenitors. The network is capable of integrating two data sources to provide accurate information of the location about the developing tissues.

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Amidst all the other do’s and don’ts, expecting parents have yet another decision to ponder on! That of cord blood banking. Keeping in mind the innumerable success stories that are circling round the globe, of how sibling’s cord blood stem cell has saved her elder or younger sister’s life to miraculous recovery within the family, cord blood cell banking is akin to opting in for a biological insurance. And on the other end of the spectrum is the reality that the process is an expensive one. So, when caught between the perils of high price and the possibility of cure (should any adverse disease were to occur), expecting parents often gets befuddled and unable to decide, if cord blood banking is worth it.

Let’s start by counting the benefits.

The blood in the placenta and the umbilical cord, which is approximately 100 millimetres in average, is a vital source rich in blood-forming stem cells, that has proved helpful in the treatment of several life-threatening ailments that includes names like Type 1 and 2 diabetes, immunological disorders, lymphoma, leukaemia, severe brain and spinal cord injuries, chronic cancers and many more. And what has really got the world pause and ponder whether they should say yes to this process, is the recent cures in ailments like Parkinson’s disease, autism and even cerebral palsy.

Cord blood stem cell banking and transplant also holds the key to the success of regenerative medicine. This simply indicates making use of stem cells to be able to regenerate tissues and organs, that haven’t been functioning in the optimal way, leading to macular degeneration which in certain chronic situations, also result in a loss of vision. Hence, today, doctors, medical experts and researchers are making use of cord blood stem cells to commission clinical trials in many phases to discover miraculous treatments to diseases and bodily disorders that otherwise is considered to be irreversible.

According to Joanne Kurtzberg, M.D. Pediatric Bone Marrow, Stem Cell Transplant Program, Duke University, the results on cord blood transplant over the past decade has been immensely successful. Patients have been benefiting to a great extent, more so because of the advancement in the world of medical science as a whole. In addition to that, hospitals are also providing advanced supportive care to patients once the transplant is over.

The other reason to say yes to cord blood banking is that, the sample you allow to store will always be at your access should you ever need it. However, this holds true when you only store your baby’s cord blood in a private bank. There’s a charge that families need to pay when enrolling for this process along with storage fees for the maintenance of the cord blood sample.

Therefore, whether you are opting in cord blood banking, wither private or public, you are actually saying yes to regenerative medicine and revolutionary cures. Private banking enables you to use it for personal requirement. And public banking extends it to the one who requires. Either ways, it’s a meaning gesture. So public or private, cord blood banking is worth it.

Sources:
https://www.newscientist.com/article/mg23531390-100-banking-a-babys-cord-blood-may-save-their-life-is-it-worth-it/
https://www.parents.com/pregnancy/my-baby/cord-blood-banking/is-cord-blood-banking-worth-it/
https://www.cordbloodbanking.com/banking/faq/

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Families that are about to welcome a new born baby often gets flooded with endless suggestions and questions. It circles everything from fixing the best baby name to the best baby diet, to keep the new born healthy and fit. And today, parents-to be are faced with yet another crucial question, i.e. whether or not to stone the baby’s cord blood cell.

Today, in a world where everyone’s on the move to grab the best medical alternative they can to secure their child’s and family, cord blood banking is one field that gets huge support. But, whereas one school of views support this process, there’s another that has opposing views. Shrouded in polar thoughts, the topic of cord blood banking has attracted a couple of conflicts to it, which blurs the main focus – that is whether it’s beneficial and who and how it’s beneficial.

A Basic Overview

Let’s start with the fundamental know-how. Cord blood is technically a minute quantity of blood that remains in the umbilical cord after a child is born. This remaining blood can be collected once the baby delivery is done. Being a rich storehouse of stem cells, cord blood is instrumental in developing chunks of blood cells and also boosts the immune system. Back in 2016, it has been calculated that 29% of patients received cord blood transplant in US and have immensely benefited from it.

For a while, scientists and medical researchers have been invested in clinical trials declaring that cord blood stem cells have effectively helped to cure more than 80 life threatening ailments. These diseases are blood related, immunological, various cancers, severe brain and spinal cord injuries as well as the Type 1 and Type 2 diabetes. This has made families having a history of severe ailments opt in for cord blood banking. The successful treatment of malignant disorders have made parents to be think of cord blood as an insurance code to their child’s and family health.

So why is it that a set of parents and families aren’t convinced about cord blood banking, despite saying yes to the process. The truth, there are certain considerations that need to be made. For instance, it is important for a stem cell to possess three fundamental properties.

• The strong capacity to regenerate, thus when they are divided they are able to produce similar daughter cells that preserves the cell line production.
• Stems cells also need to have the capacity to distinguish, that they are able to set up specific form and functions. For instance, developing into a liver tissue in place of a cardiac tissue. However, stem cells that branch out into any cell type in the human body is termed as pluripotent and the ones which branch into a pre-destiny is called multipotent.
• And finally stem cells also need to be able to refill the tissue cells that has been damaged severely in the blood, skin or gut and needs to be renewed at an ongoing basis from the stem cell source

Hence, the umbilical cord which according to few was considered to be of no medical use post child birth, has been proved wrong through the successful cord blood transplants. However, the fact that there exist still few disappointments on the subject could be traced to its disadvantages. And one being a minimum quantity of 50 to 200 ml needs to be made ready for collection. If the amount is less, then the sample is invalid. However, in majority there seems to be not ample blood. Furthermore, a meagre 8 to 12 % of cord blood units have apt stem cells for an individual transplant who weighs 80 kgs.

So, once you address the conflicting views and also know the practical side of cord blood, then whether to opt in for banking becomes easy for you.

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Is it possible to imagine a world free from Autism? Or practically a world where medical feats help to treat Autism back to normalcy? This wishful thinking might just translate into reality. Thanks to the research on regenerative medicines using cord blood cells. Recently, a group of researchers have been working to discover that cord blood cells might have a way to cure Autism Spectrum Disorder (ASD). It has been observed that umbilical cord blood can be instrumental in repairing the body in ASD, which further holds promise for a probable treatment.

Many Americans have been resorting to this to heal ASD in their child. The brand-new U.S clinical trial is said to be the very first to get U.S. Food and Drug Administration’s approval. Administered and managed by Dr. Michael Chez, the Director of Paediatric Neurology, Sutter Medical Center, a team of researchers sometime back had published the outcome of a Phase II Clinical Trial that looked into the effectiveness and security of autologous umbilical cord blood cells for autistic children that deployed a placebo-managed, double-blind design. Back in 2017, these medical researchers at Duke University also published a Phase I security trial assessing autologous umbilical cord blood in autistic children. The emphasis on cord blood cells being a potential cellular therapy accompanied with favourable findings from past clinical studies, promises a brighter future in treating ASD. CBR in its initiative to explore the potential of stem cells has offered institutional funding for Stutter clinical researchers.

The Scope of Newborn Stem Cells
The emphasis on cord blood cells being effective in treating ASD stems from its innate benefits. Umbilical cord blood cells have set of benefits such as:

• Anti-inflammatory properties – Research has revealed that cord blood cells possess the capacity to normalize inflammation and migrate to the location of neurologic injury.
• Secure and available – Umbilical cord blood is collected easily when a baby is born and can be stored indefinitely for any future use by a close family member or the newborn donor
• Bystander effect- It is said that infused cord blood cells secrete factors which regenerates the body’s innate healing mechanism in and around a surrounding tissue through paracrine signalling, which is also called the bystander effect.

ASD Research Kickstarts
The very first clinical research making use of cord blood that was earlier banked from the autistic child was completed recently. The children between the age group 2 and 6 who had ASD were researched on for this study. The objective of this trial was to evaluate if cord blood was a secure means to use it on these children and record any health improvement that might occur in a year. This children team was given one dose of cord blood cells via intravenous infusion and the effects were observed. This study paved the foundation for other advanced studies to commence in future. It proved that cord blood cell was a secure therapy mode when transferred as an infusion. It also recognized certain symptoms that could have been influenced.

These clinical trials highlight the significance of banking an infant’s stem cells. It also offers valid reasons as to why families should spend the dear amount in cord blood banking processes. Modern day medicine scene is at an ongoing evolution stage. And cord blood cell researches carry on to come with new and revolutionary treatment choices for a wide range of medical conditions that were previously said to be incurable. Clinical trials understanding the use of cord blood cells to cure Type 1 Diabetes, cerebral palsy and stroke are already in progress. The chance of ASD being treatable with cord blood cell is a huge boon that the medical world can gift humanity.

Sources:
https://www.autismspeaks.org/blog/2013/01/04/cord-blood-banking
https://www.cordblood.com/stem-cell-research/cord-blood-research/autism

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Our immune system is calibrated to provide us with specific protection shields against harmful diseases, and other conditions too. On being influenced by the excessive active cells and intruder cells, interfering with its physical functions, our immune system is more likely to lose its strength to fight diseases, and as a result it causes a range of autoimmune diseases or different types of leukemia.

Immune cells mostly referred to as T cells can reverse the effects of these defective cells and reinstate the balance through a reprogram technique. With a reprogram technique manipulating the performances of certain immune cells, we can remain unaffected to the prevalence of different diseases, including cancers and psoriasis. This also fosters the development of new treatment options.

This is how the scientists at the Gladstone Institute have expressed about their latest findings. A renowned journal Nature has published about this metabolic mechanism in an elaborate way.

How Much Effective Is the Whole Method Of Reprogramming T Cells?

The whole method of manipulating T cells or immune cells, advocates for the reduction of anti-inflammatory reactions, developed in the immune system through pro-inflammatory genes. So, the inflammation causing factors in the immune system could be curtailed using this modification theory.

On the basis of the findings, there are two types of cells termed as Effector T cells and Regulatory T cells. These two cells play a key role in regulating our whole immune system. The Effector T cells build a shield against the pathogens so as to protect us from the vulnerability to infections, once the immune system gets charged up. The Regulatory T cells on the other hand, restrict further attacks of the pathogens to the healthy parts of our body.

With Regulatory T cells being converted into Effector T cells under the influence of reprogramming technique, a molecule drug appears to be a great precursor in the whole process. So, this method seems to be effective in converting one cell into another cell type.

The conversion methods show promise to find the etiology of the disease, especially auto-immune diseases, making it possible to eradicate the diseases from its root. Say, when effector T cells are charged up excessively in the body in the presence of autoimmune disease, the T cells expose the body to harmful effects. But by converting these Regulatory T cells, the balance of the immune system can be reinstated, followed by the reduction of hyperactivity.

Treatment for Immune-Oncology

Another way, the study is intensifying our hopes against the deadly effects of cancers and tumor related disorders. We can achieve a better outcome for immune-oncology and cancer treatments. The process is ineffective in influencing the cancer cells though; it defies its attacks on the activation of the immune system.

Since cancer cells seem to be stronger to influence Regulatory T cells, they make a room in the immune system for the growth, and hence, the detection becomes quite tough. But, the findings could help us in detecting cancerous cells and destroying them by strengthening the immune system through a conversion of Effector T cells from Regulatory T cells.

More Scopes for Stem Cell Therapies

It also brings a revolutionary milestone for stem cell therapies. With the development of Regulatory T cells, we could reverse the effects of graft-versus-host-disease, and also make our body adjust to the newly-transplanted cells.

With a reprogram technology for immune system, we could defend ourselves from a range of diseases, once which were termed as unavoidable medical cases. Hence, we can live our dream to make a disease-free world in the future.

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A neurodegenerative disease when occurred leads us to a series of complications all together. The occurrence of this devastating disease exposes us to dysarthria – a condition in which we cannot speak properly, dyspnea- a distress in breathing, and also dysphagia, which deteriorates our ability to swallow easily. It is rapidly characterized by an intense weakness in our muscles. Now, you could easily recognize the characterization of this nasty disease, which is known as Amyotrophic lateral sclerosis (ALS), or popularly known as Lou Gehrig’s diseases or motor neuron disease.

Being a motor neuron disease, ALS or Lou Gehrig’s disease causes degeneration to the motor neurons found in our brain and spinal cord. That’s another reason, why do we find difficulty in walking; and gradually why this restricts us from developing strong muscle control. The cruelty of the disorder is so harsh and unbearable, that it slowly leads us to the threshold of death. To our greater dismay and misfortune, there is currently no available treatment to defer the effects of the disease and cure it permanently.

The Characteristic of ALS Or Lou Gehrig’s Disease

The prevalence of the disease is highly noticed in the Western Counties uniformly. The onset of the disease is most likely to hit the patients at the age of 60 years, but patients approaching their 30’s are not averse to this neurodegenerative disease too, followed by 5% of the total juvenile populations.

However, the pathogenesis of the disease is still unclear, and it seems that the pathogenic cellular mechanisms could be at the root of the occurrence of the disease.

If we further explore, we get to know that many of the patients suffering from this disease, do not have any family history, while others seem to express a hereditary factor.

Lou Gehrig’s is a disease with no possible treatment in sight though, yet some of its conditions are likely to be treated. So, efforts and clinical trials are on the go to improve the life of the patients to some extent. And, an approach to find more possibilities with the stem cell transplant is in the pipeline also.

Phase III Clinical Trials for To Alleviate the Conditions Of ALS

California’s Stem Cell Agency feels an urge and need to invest $15.9 million in a clinical trial for Lou Gehrig’s disease in an association with BrainStorm Cell Therapeutics.

The organization is dependent on the mesenchymal stem cells taken from the participating patients’ bone marrow in the clinical trials. With these stem cells, the researchers at the agency are developing a therapy called NurOwn. The mesenchymal cells are grown in the petri dish in the lab followed by a reprogramming method. The reprogram will command the cells to produce a protein called glial cell infused with nuerotropic factors. Neurotropic factors or GDNF has the potential to stop the further deterioration of the motor neurons caused by ALS. They also protect the cells and reduce the risks of immunodeficiency in the patients.

The ongoing trial received a positive signal from the patients’ tolerance capacity to NurOwn Therapy, and hence it raises hopes for the patients with ALS. It is capable of restricting the further adverse effects, and also deferring the progress of the disorder in a short period of time.

NurOwn therapy infused with Neurotropic factors from mesenchymal cells is aimed at getting an approval from the US Food and Drug Administration (FDA) so as to help people like us with ALS.

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We are well aware of the link between diabetes and obesity. While the exact etiology of diabetes is still unclear, there are some factors, which double the risks of glucose intolerances in us, and obesity or weight gain are amongst those factors. With the body mass index or BMI being at 30 or more, it fosters the development of Type 2 diabetes in obese people, as opposed to those having a BMI of less than 22. Simultaneously, obesity or overweight is believed to cause Type 2 diabetes at the rate of 80-85%.

Obese people tend to have excessive fat around their tummy, and it appears to be susceptible to “pro-inflammatory” hormones, making it less responsive to insulin. As a result, it contributes to the development of diabetes in obese people.

However, you can do away with this problem using skin graft gene therapy. This is how the scientists at the University of Chicago promise to do for those suffering from diabetes and obesity at the same time. By revealing the results of their latest finding in the journal Stem Cell, they proved that using CRISPR gene editing technology, skin grafts can be developed. And this skin graft is capable of reducing the signs of obesity and diabetes in mice.

Since the engineered skin graft can have a longer lifespan for the mice, it is conceived to use the technique to treat a range of conditions in human as well.

The Findings of the Study

The clustered regularly interspaced short palindromic repeats or CRISPR technology were used to create a skin graft by manipulating the genome with greater efficacy. Xiaoyang Wu, assistant professor of the research, believes that this finding could turn out to be a cheaper form of stem cell transplant with a better outcome. If its efficacy stands potential for humans, it is effective in warding off a wide range of conditions including genetic disorder hemophilia.

Why Engineered Skin Graft a Safer and Better Gene Therapy Option

The gene-editing using CRISPR is quicker and safer as compared to current methods of DNA patch editing in humans as they pose some risks. The administration process of the skin grafts in humans is easier, while other processes of the introduction of genes require a viral delivery, prompting for the development of tumors, and also interfering with immune responses in them.

As far as the engineered skin graft is concerned, they are easily accessible, and the risks are more likely to be removed with a quicker effect.

Observation of The Study

Using CRISPR technology, an engineered skin graft was developed to use on the mice in the lab. It targeted the mutations in the GLP-1 gene to stabilize it and secrete it in the bloodstream. Mice having skin grafts dropped their glucose levels as their insulin level rose on a normal diet. While mice on a high-fat diet became obese, but their weight reduced once an administration of GLP-1 in their bloodstream was introduced coupled with the drug doxycycline. So, the engineered skin graft technology is promising not only for diabetes, but also for obesity.

With CRISPR gene-editing technology showing some fruitful results for alleviating the symptoms of diabetes and also obesity together, we can hope that this stem cell therapy could relieve many conditions associated with metabolic disorders too.

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Unexpected that unassuming mice and zebrafish can help repair damaged hearts, a new study has revealed.

The zebrafish has the ability to stitch its severed spine again and the mouse has a substance surrounding its hearts that can patch up the injured or broken heart.

The researchers injected the extracellular matrix of the zebrafish into the damaged cardiac tissue of a mouse. The Zebrafish cellular matrix enhanced the cell replication, tissue regeneration and also improved the functioning of the heart in the mouse. The research reveals that proteins play a very important role in this transformation.

The power to heal quickly is seen only in super humans and is referred to as a super ability. Humans cannot re-grow their limbs like starfish. But children who lose their fingertips provided the nail is still safe have found that their tips can re-grow again. With age this ability gets turned off. The study along with research is to help study the MNDCM so this ability can be turned on again.

Every year a few lakh suffer from heart attacks and blocked arteries. A blocked artery deprives the heart of blood and oxygen its basic fuel. The longer the blockage lasts the more cells die and the heart is damaged permanently.

When children are born they have a large number of heart muscle cells called mononuclear diploid cardiomyocyte or MNDCM. These cells have regenerative properties and can rebuild the heart muscle. But as we grow older the cells reduce leading to a heart attack. MNDCM are few and hence are not able to repair the damage caused by the heart attack.

After an attack the healing is a long process and once the cells are damaged the muscle cells cardiomyocytes are replaced by scared tissue, which cannot contract and pump. This further increases the stress on the remaining heart muscle and then leads to heart failure.

The researchers have found that a few mice have less than two percent of the MNDCMs while others have it in a larger percentage. Thus, those mice with a higher number of MNDCMs are able to regenerate the heart muscle after an injury or a heart attack. A wide genetic study has revealed the gene Tnni3k that plays a major role in generating the MNDCMs.

Turning off the Tnni3k gene resulted the increased number of MNDCMs thus increasing the ability to regenerate the heart. But when the same gene Tnni3k was activated in the zebrafish it reduced the number of MNDCMs and destroyed its ability to repair damaged heart. ts

But it’s still a long way from being used on humans. This study is just the first step towards evolving a medicine. The Tnni3k can be modulated and hence can be used to create prescription medicine. The Tnni3k overtime can help contain more regenerative cells in adult hearts and prevent heart failure.

The ultimate goal of this research is regeneration of the cells to heal the body. Quick healing is useful in a young child, the body needs to regenerate.

Tnni3k in zebrafish promoted cardiomyocyte compromised heart regeneration. The results corroborate the importance of MNDCMs in heart regeneration. It implies that heart regeneration is not same in every individual, but it is influenced by many genes.

It is likely that several things influence the functional and morphological outcome after a heart injury, which includes cardiomyocyte proliferation, cardiomyocyte hypertrophy, collagen deposition by fibroblasts (scarring), regrowth of coronary vasculature etc.

Sources:
https://www.nature.com/articles/ng.3929
https://blog.cirm.ca.gov/2017/08/07/how-mice-and-zebrafish-are-unlocking-clues-to-repairing-damaged-hearts/
https://www.scoopnest.com/s/How%20Zebrafish/

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Pregnancy is a time when you are prone to sleepless nights. When you frequently catch yourself being wide awake at 2:30 am, you are far away from a healthy sleep cycle! And the impacts of which you may have already started to feel or will feel in the forthcoming days. Excess fatigue, tired looking skin area around the eyes, dry mouth, increased hunger pangs, heightened sugar cravings, problems related to digestions, joint pains, body aches are some of the perils of missing sound sleep! Developing insomnia is the most chronic danger of all.

If you have been attempting to launch into a healthy, timely sleeping cycle lately, here are few easy ways to go about it.

Bid farewell to caffeine and other chemicals that interrupt sleep

Coffee or any caffeinated products reduce sleep quality! Binging on coffee late night or evening especially during pregnancy is a stimulant that keeps you awake. Eliminating coffee, chocolate and cola for 4 to 6 hours prior to your sleeping time, will bring you good sleep.

Reading prior to sleeping induces good sleep

This is an age-old practice fostered by our parents and grand-parents! Light reading is apt before sleeping. It gradually induces a state of complete relaxation which transitions into deep sleep. When the body is relaxed the body’s cortisol levels, (a stress hormone) drop and relaxing hormones function smooth, thereby making it easy to sleep calm and healthy and wake up rejuvenated.

Inculcate the habit of exercise daily

Might appear out of context, but regular exercise plays a crucial part in developing a smooth sleep cycle. But you need to exercise at the right time. Ideally, early morning or evening. Exercise or any physical activity helps to release the accumulated stress and tension embedded in our body, muscles, tissues and sometimes in our mind as well. However, since exercising produces cortisol, that activates the brains alerting process, it’s essential to come to a state of complete rest post exercise and prior to sleep. So, exercising early morning is best, followed by evening, where you can have a comfortable gap of at least 4 to 5 hours before sleep. However, have a word with your healthcare provider the extent of the exercising you may indulge during the pregnancy period.

Maintaining a diary or journal

Pregnancy can be also bring with it tons of emotional upheavals. Sleeping is the only time, when the mind and body is free of work. Hence, it circles back and forth unsolved issues, pent up emotions, to-be completed work assignments, apprehensions about instalments and replay it all as a loop tape in the brain, since now the mind is empty of work agendas. This constant thinking corrupts sleep cycle. Sleep experts recommend keeping a journal and writing down your day’s experiences and worries prior to sleep. That way, we can trick our mind to think that we have addressed all our problems and can sleep restfully.

Getting into the practice of deep breathing

Holistic healers and health experts recommend deep breathing practice every day for about 5 minutes, twice. The process of deep breathing minimizes blood pressure, heart rate, eases body, its muscles and tissues, releases endorphins and other feel good hormones and gently prepares our body for sleep. Wondering how to go about it? Breathe in for 5 seconds, pause for 3 seconds and breathe out for 5 seconds. You can start by completing 8 sets to start with and pace up gradually to 15 sets. Practicing this daily in morning and evening will prove beneficial.

By shifting to these simple healthy practices, you can strike out these unhealthy sleep patterns forever and enjoy complete vitality during pregnancy!

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Being a mother is probably the most joyous experience for a woman! The fact that she is now the vessel of a new life brings her immense happiness and a tad bit apprehension, because every mother wants a safe delivery so that their little one can walk out of the womb all healthy to experience the wonderful world. That aside, pregnancy brings with it its own wonders. The physical changes and emotional fluctuations are unavoidable. But what acts as a silvering lining of delight are moments like when the mother feels a baby kick inside a womb which most expecting mothers describe as a “soul communication”. And even fathers to be have their moments of inexplicable elation when they feel the baby kick!

A man can never approximate what a woman feels with a life inside her womb! When I heard that my wife was pregnant I was ecstatic and got busy to arrange the best environment for our little one, who’s already growing inside my wife’ womb with every passing say. Countless anecdotes shared by my friends and their wives made me curious as to how would that sensation of a baby kick feels like, both for a man and a woman. Can that soft piece of life inside the womb sense what a mother feels when she feels the kick? If even I get to feel the kick will my baby know I am his/her father. My mind hovered around countless thoughts and I felt bubbles of joy bursting inside of me.

During her pregnancy period, my wife was curious to experience the baby kick! She often said, since a life was growing inside of her, she needed a sign from the Universe that she’s doing it all right. Also, being metaphysically inclined, she wanted to connect with our little one even before delivery. So, she sometimes before sleeping at night, she would recline back and have be talk to the bump waiting to feel the kick. We followed this before sleep ritual for a while and stopped, as nothing happened. And then one day, when I was in office my wife rang up in her total elation, sharing that she felt our baby kick. I could sense her overflowing happiness and secretly desired to experience what she did.

My wife had started feeling our baby right from the eleventh week of her pregnancy. First, I thought, it could be an anticipatory imagination. But as my wife tells me now, it wasn’t and that Ria, our little one did start to communicate with her. There were times when she experienced minimized fetal movement and got into bouts of worry, thinking if all’s well with our little one. And as she sailed through her pregnancy I could see it in her eyes, how she wished for me to feel our baby kick.

And one fine day, at a winter night on the 20th week of her pregnancy whilst we were sleeping, my wife recalls that suddenly, she felt our baby kicking rather too frequently. She secretly woke up and didn’t inform me anything about it. She kept her hand on the baby bump and was silently feeling the baby kicks and responding to it with a loving though. Then one day on the 21st week, she felt slightly nauseous at night.

I woke up, attended her physically challenging state and when the queasiness reduced I was helping her recline back to bed. We both exchanged a loving glance and touched her womb, and pat came a soft kick. She said, “Our little is talking to us” and smiled. As she lied down my palm were on her baby belly and there were few more soft kicks. This continued for a while and then we went back to sleep.

Now that we have our little Ria beside us, I can only get back to that December winter night when I first felt her communicating with me. Getting to experience your baby kick is a surreal experience that can only be felt deeply, never expressed in totality.

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