1. What are cord blood stem cells?
Cord blood is blood that remains in the umbilical cord following the birth of a baby and after the umbilical cord is cut. During pregnancy, the umbilical cord functions as a lifeline between mother and child. After a baby’s delivery, the cord blood present in the umbilical cord could offer hope for the child and maybe members of the family.
Cord blood is a rich source of Haematopoietic Stem Cells (HSCs), which are primarily responsible for replenishing blood and regenerating the immune system. They have the unique ability to differentiate into various cell types found in blood as depicted in the diagram below:
- Red blood cells – which transport oxygen
- White blood cells – which produce antibodies and fight bacteria
- Platelets – which assist blood clotting
2. What does cord blood stem cells do?
- Replace and regenerate damaged or diseased bone marrow
- Treatment for blood cancers
- Correct genetic defects (sibling/allogeneic transplantation)
- Potential for cellular therapy and regenerative medicine
3. What are some of the diseases treated by stem cells?
The list of diseases treated by stem cells can be found here.
4. How much does it cost to save my baby’s cord blood?
Please call us at our hotline numbers (+91) 98301 66200 or 1800 345 6200. Alternatively, you can also send an email to email@example.com for our latest savings plans.
5. How long can my baby’s cord blood stem cells be stored?
Theoretically, the shelf-life of cells stored at liquid nitrogen temperatures has been estimated to be of 1,000 years1.
In recent studies, it is found that there is efficient recovery from cord blood stem cells cryopreserved up to 21-23.5years2.
- Jens O.M. Karlsson, Mehmet Toner, Long-term storage of tissues by cryopreservation: critical issues. Biomaterials 17 (1996) 243-256.
- Hal E. Broxmeyer, Man-Ryul Lee, Giao Hangoc, et. al., Hematopoietic stem/progenitor cells, generation of induced pluripotent stem cells, and isolation of endothelial progenitors from 21- to 23.5- year cryopreserved cord blood. Blood 2011 117:4773-4777. Doi:10.1182/blood-2011-01-330514
6. How is my baby’s cord blood stored?
CordLife uses the U.S. FDA approved cryogenic storage pouch. This multi-compartmentalised cryobag has 20 percent and 80 percent compartments. This cryobag also has 2 integrally attached segments which are in compliance with AABB and FACT-Netcord standards. This dual compartment enables stem cell expansion in future. That means that when this stem cell expansion technology is commercially viable, you can withdraw 80 percent of the stem cells for immediate use /treatment while continuing to store the balance for later expansion.
The integral segments also provide the safety and assurance that additional product testing is performed on the associated unit thereby eliminating testing and cord blood unit mix ups. This is to allow for additional testing of the sample should it be required in the future, or for viability testing prior to a transplant. This storage pouch is made of a special material designed specifically to withstand cryogenic temperatures.
Your baby’s cord blood will be stored in vacuum insulated cryogenic storage tanks that are specially designed to remain at optimal cryogenic temperature of below -150°C for cell storage over a long period. CordLife uses MVE Anti-contamination Vapour-phase Liquid Nitrogen Storage System for long-term stem cell cryopreservation.
Vapour-phase storage is preferred over liquid-phase storage1 as it eliminates the chance of cross contamination between cord blood units as compared with those stored in liquid nitrogen.
The MVE Anti-contamination Vapour-phase Liquid Nitrogen Storage System operates perfectly, even without electrical supply, and is 100% reliable and failsafe with no chance of robotic malfunction. Unlike other storage systems available in the market today, our tanks have never been recalled by the U.S. FDA or the manufacturer.
Over 99% of private cord blood banks also use only vapour-phase freezers. Presently, the majority of stem cell transplantations used cord blood units stored in vapour freezers.
- Best practices for Repositories I: Collection, Storage, and Retrieval of Human Biological Materials for Research
7. How is my baby’s cord blood collected by my Ob-gyne?
Immediately after the delivery of your baby, the cord is clamped and your baby separated from the cord and moved from the birthing area. The doctor then collects the umbilical cord blood by inserting a needle into the cord vein, and draining the blood into a blood bag.
This procedure is painless and risk-free to both you and your baby. It takes about 3 minutes and does not alter the birthing process in any way. It can be done with either a vaginal or caesarean delivery.
Please note that the final decision of whether the cord blood collection should take place will always reside with your caregiver whose first priority is the safety of you and your baby.
8. How does a stem cell transplant work?
- Stem cell rescue reconstitutes a patient’s blood and immune system
- This is carried out after chemotherapy and radiotherapy which destroy blood cells
- Stem cells are infused intravenously into the patient’s blood stream
- Once in the blood stream, they migrate to the bone marrow
- They then differentiate into three blood cell types – red, white and platelets
- The differentiation initiates the regeneration of the patient’s blood and immune system
9. How do I enroll?
Contact us at our Hotline (+91) 98301 66200 or 1800 345 6200 you can email us firstname.lastname@example.org to make an appointment with our Cord Blood Banking Consultant.
* If you are due within the next 4 - 6 weeks, we strongly recommend you to contact us immediately for enrolment because this will ensure all necessary steps are completed before your baby's arrival.
10. Can I store my baby’s cord blood if my blood sample is tested positive for Hepatitis B?
You may still continue to store your baby's cord blood (with additional consent given to CordLife), or elect to discard the umbilical cord blood unit.
CordLife conducts two different tests for Hepatitis B virus (HBV) on maternal blood, namely:
- Hepatitis B Surface Antigen (HBsAg)
- Hepatitis B Core Antibody (Anti-HBc (Total))
Usually, the attending transplant physician will make the decision whether to use a cord blood unit where the maternal blood was tested positive for Hepatitis B for transplant, based on various factors particular to the patient, the cord blood unit intended for use, and the availability of other HLA-matched donor.
11. Why should I save my baby’s cord blood stem cells?
- 1 in 200 individuals1 may need a haematopoietic stem cells (HSCs) transplant by the age of 70.
- 60% higher chance2 of match versus bone marrow in a family.
- Research showed that patients have a lower chance of complications in transplants when they receive stem cells from a relative3.
- Some of the most common cancers are treatable with stem cell transplant. For instance, For instance, Lymphoma and Leukaemia are two of the top 10 common cancers for adults4 and among the top five most common childhood cancers5 in India.
- A guaranteed match for autologous transplants (where the donor and recipient are the same individual).
- A readily available supply of stored haematopoietic stem cells. This compares well to having to do a national or international search which is costly and time-consuming in an already time critical situation.
- Lower risk of Graft vs. Host Disease (GvHD) for autologous transplants, a situation where the transplanted tissue attacks the patient’s own tissue.
- Umbilical cord blood stem cells are younger, have a higher rate of engraftment and are more tolerant to tissue mismatches, compared to other types of stem cells, e.g. bone marrow.
- Ease of collection, which is pain-free and risk-free to both mother and child.
- It is once-in-a-life time chance to collect cord blood – a readily available source when needed in the future.
1 Nietfeld JJ, Pasquini MC, Logan BR, et. al. 2008.U.S. Biology of Blood and Marrow Transplantation. 14:316-322.
2 Beatty PG, Boucher KM, Mori M, et. al. 2000. Human Immunology. 61, 834-840.
3 Wagner JE, Steinbuch M, Kernan NA, et. al. 1995. The Lancet.346:214-219; Kurtzberg J, Laughin M, Graham ML, et. al. 1996. New England Journal of Medicine. 335:157-66.
4 Swaminathan, et. al. 2011. Trends in cancer incidence in Chennai city (1982–2006) and statewide predictions of future burden in Tamil Nadu (2007–16). National Medical Journal of India: 24:2:72-7
5 Swaminathan, et. al. 2008. Childhood cancers in Chennai, India, 1990 – 2001: Incidence and survival. Int. J. Cancer: 122, 2607-11
12. What happens after the full 18-years of storage?
The ownership of the cord blood will be transferred over to your child once he/she reaches the legal adult age of 18 years and upon the renewal of the agreement. Your child will be prompted to continue storage thereafter at the prevailing fees.
13. What happens if CordLife ceases operations?
The continuation of storage of your child’s umbilical cord blood stem cells is of utmost importance to us. In the unlikely event that CordLife ceases its operations, CordLife may assign its rights under the Agreement to another provider of cord blood banking storage facilities as long as that provider meets the necessary standards at the relevant time.